Browsing by Author "Bangsberg, David R."
Now showing items 1-20 of 55
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Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypes
Mann, Jaclyn K; Byakwaga, Helen; Kuang, Xiaomei T; Le, Anh Q; Brumme, Chanson J; Mwimanzi, Philip; Omarjee, Saleha; Martin, Eric; Lee, Guinevere Q; Baraki, Bemuluyigza; Danroth, Ryan; McCloskey, Rosemary; Muzoora, Conrad; Bangsberg, David R; Hunt, Peter W; Goulder, Philip JR; Walker, Bruce D; Harrigan, P Richard; Martin, Jeff N; Ndung’u, Thumbi; Brockman, Mark A; Brumme, Zabrina L (BioMed Central, 2013)Background: The highly genetically diverse HIV-1 group M subtypes may differ in their biological properties. Nef is an important mediator of viral pathogenicity; however, to date, a comprehensive inter-subtype comparison ... -
Adherence to Antiretroviral Prophylaxis for HIV Prevention: A Substudy Cohort within a Clinical Trial of Serodiscordant Couples in East Africa
Haberer, Jessica E.; Baeten, Jared M.; Campbell, James; Wangisi, Jonathan; Katabira, Elly; Ronald, Allan; Tumwesigye, Elioda; Psaros, Christina; Safren, Steven A.; Ware, Norma C.; Thomas, Katherine K.; Donnell, Deborah; Krows, Meighan; Kidoguchi, Lara; Celum, Connie; Bangsberg, David R. (Public Library of Science, 2013)Background: Randomized clinical trials of oral antiretroviral pre-exposure prophylaxis (PrEP) for HIV prevention have widely divergent efficacy estimates, ranging from 0% to 75%. These discrepancies are likely due to ... -
Adolescent Abstinence and Unprotected Sex in CyberSenga, an Internet-Based HIV Prevention Program: Randomized Clinical Trial of Efficacy
Ybarra, Michele L.; Bull, Sheana S.; Prescott, Tonya L.; Korchmaros, Josephine D.; Bangsberg, David R.; Kiwanuka, Julius P. (Public Library of Science, 2013)Context Cost-effective, scalable programs are urgently needed in countries deeply affected by HIV. Methods: This parallel-group RCT was conducted in four secondary schools in Mbarara, Uganda. Participants were 12 years and ... -
Alcohol use and HIV serostatus of partner predict high-risk sexual behavior among patients receiving antiretroviral therapy in South Western Uganda
Bajunirwe, Francis; Bangsberg, David Roy; Sethi, Ajay K (BioMed Central, 2013)Background: Antiretroviral treatment restores the physical and immunological function for patients with HIV/AIDS and the return of sexual desire. The frequency and correlates of sexual activity among patients receiving ART ... -
Antiretroviral Regimen and Suboptimal Medication Adherence Are Associated With Low-Level Human Immunodeficiency Virus Viremia
Konstantopoulos, Christina; Ribaudo, Heather; Ragland, Kathleen; Bangsberg, David R.; Li, Jonathan Z. (Oxford University Press, 2015)Episodes of human immunodeficiency virus low-level viremia (LLV) are common in the clinical setting, but its association with antiretroviral therapy (ART) regimen and adherence remains unclear. Antiretroviral therapy ... -
ART adherence changes among patients in community substance use treatment: a preliminary analysis from MACH14
Rosen, Marc I; Black, Anne C; Arnsten, Julia H; Simoni, Jane M; Wagner, Glann J; Goggin, Kathleen; Remien, Robert H; Golin, Carol E; Wang, Yan; Bangsberg, David Roy; Liu, Honghu H (BioMed Central, 2012)Background: Opiate substitution treatment has been associated with better adherence to lifesaving antiretroviral medications, but the impact of other substance abuse treatment on adherence is unknown. Findings: In this ... -
Causes of Death on Antiretroviral Therapy: A Post-Mortem Study from South Africa
Wong, Emily Beth; Omar, Tanvier; Setlhako, Gosetsemang J.; Osih, Regina; Feldman, Charles; Murdoch, David M.; Martinson, Neil A.; Bangsberg, David Roy; Venter, W. D. F. (Public Library of Science, 2012)Background: Mortality in the first months of antiretroviral therapy (ART) is a significant clinical problem in sub-Saharan Africa. To date, no post-mortem study has investigated the causes of mortality in these patients. ... -
A combination SMS and transportation reimbursement intervention to improve HIV care following abnormal CD4 test results in rural Uganda: a prospective observational cohort study
Siedner, Mark J.; Santorino, Data; Lankowski, Alexander J.; Kanyesigye, Michael; Bwana, Mwebesa B.; Haberer, Jessica E.; Bangsberg, David R. (BioMed Central, 2015)Background: Up to 50 % of HIV-infected persons in sub-Saharan Africa are lost from care between HIV diagnosis and antiretroviral therapy (ART) initiation. Structural barriers, including cost of transportation to clinic and ... -
Comparison of Self-Reported Alcohol Consumption to Phosphatidylethanol Measurement among HIV-Infected Patients Initiating Antiretroviral Treatment in Southwestern Uganda
Bajunirwe, Francis; Haberer, Jessica E.; Boum, Yap; Hunt, Peter; Mocello, Rain; Martin, Jeffrey N.; Bangsberg, David R.; Hahn, Judith A. (Public Library of Science, 2014)Background: Alcohol consumption among HIV-infected patients may accelerate HIV disease progression or reduce antiretroviral therapy adherence. Self-reported alcohol use is frequently under-reported due to social desirability ... -
Cytomegalovirus-Specific T Cells Persist at Very High Levels during Long-Term Antiretroviral Treatment of HIV Disease
Naeger, David M.; Martin, Jeffrey Michael; Sinclair, Elizabeth; Hunt, Peter K.; Bangsberg, David Roy; Hecht, Frederick; Hsue, Priscilla; McCune, Joseph M.; Deeks, Steven G. (Public Library of Science, 2010)Background: In healthy, HIV seronegative, CMV seropositive adults, a large proportion of T cells are CMV-specific. High-level CMV-specific T cell responses are associated with accelerated immunologic aging (‘‘immunosenesence’’) ... -
Depression During Pregnancy and the Postpartum Among HIV-Infected Women on Antiretroviral Therapy in Uganda
Kaida, Angela; Matthews, Lynn T.; Ashaba, Scholastic; Tsai, Alexander C.; Kanters, Steve; Robak, Magdalena; Psaros, Christina; Kabakyenga, Jerome; Boum, Yap; Haberer, Jessica E.; Martin, Jeffrey N.; Hunt, Peter W.; Bangsberg, David R. (JAIDS Journal of Acquired Immune Deficiency Syndromes, 2014)Background: Among HIV-infected women, perinatal depression compromises clinical, maternal, and child health outcomes. Antiretroviral therapy (ART) is associated with lower depression symptom severity but the uniformity of ... -
Diminishing Availability of Publicly Funded Slots for Antiretroviral Initiation Among HIV-Infected ART-Eligible Patients in Uganda
Geng, Elvin H.; Bwana, Mwebesa B.; Kabakyenga, Jerome; Muyindike, Winnie; Emenyonu, Nneka I.; Musinguzi, Nicholas; Mugyenyi, Peter; Myer, Landon; Martin, Jeffrey N.; Bangsberg, David Roy (Public Library of Science, 2010)Background: The impact of flat-line funding in the global scale up of antiretroviral therapy (ART) for HIV-infected patients in Africa has not yet been well described. Methods: We evaluated ART-eligible patients and patients ... -
Disinhibition in Risky Sexual Behavior in Men, but Not Women, during Four Years of Antiretroviral Therapy in Rural, Southwestern Uganda
Kembabazi, Annet; Bajunirwe, Francis; Hunt, Peter W.; Martin, Jeffrey N.; Muzoora, Conrad; Haberer, Jessica E.; Bangsberg, David R.; Siedner, Mark J. (Public Library of Science, 2013)Background: In resource-rich areas, risky sexual behavior (RSB) largely diminishes after initiation of anti-retroviral therapy, with notable exceptions among some populations who perceive a protected benefit from anti-retroviral ... -
Dissemination of Research Findings to Research Participants Living with HIV in Rural Uganda: Challenges and Rewards
Baylor, Anna; Muzoora, Conrad; Bwana, Mwebsa; Kembabazi, Annet; Haberer, Jessica; Matthews, Lynn Turner; Tsai, Alexander Chung-Yu; Hunt, Peter K.; Martin, Jeffrey N.; Bangsberg, David Roy (Public Library of Science, 2013)David Bangsberg and colleagues explore the challenges and rewards of sharing research findings with participants living with HIV enrolled in observational research in rural sub-Saharan Africa. -
Empiric Deworming and CD4 Count Recovery in HIV-Infected Ugandans Initiating Antiretroviral Therapy
Lankowski, Alexander J.; Tsai, Alexander C.; Kanyesigye, Michael; Bwana, Mwebesa; Haberer, Jessica E.; Wenger, Megan; Martin, Jeffrey N.; Bangsberg, David R.; Hunt, Peter W.; Siedner, Mark J. (Public Library of Science, 2014)Background: There is conflicting evidence on the immunologic benefit of treating helminth co-infections (“deworming”) in HIV-infected individuals. Several studies have documented reduced viral load and increased CD4 count ... -
Explaining Adherence Success in Sub-Saharan Africa: An Ethnographic Study
Idoko, John; Kaaya, Sylvia; Biraro, Irene Andia; Agbaji, Oche; Beyrer, Chris; Ware, Norma Clara; Wyatt, Monique A.; Chalamilla, Guerino E.; Bangsberg, David Roy (Public Library of Science, 2009)Background: Individuals living with HIV/AIDS in sub-Saharan Africa generally take more than 90% of prescribed doses of antiretroviral therapy (ART). This number exceeds the levels of adherence observed in North America and ... -
Food Insecurity Among Homeless and Marginally Housed Individuals Living with HIV/AIDS in San Francisco
Weiser, Sheri D.; Bangsberg, David Roy; Kegeles, Susan; Ragland, Kathleen; Kushel, Margot B.; Frongillo, Edward A. (Springer Verlag, 2009)Food insecurity is a risk factor for both HIV transmission and worse HIV clinical outcomes. We examined the prevalence of and factors associated with food insecurity among homeless and marginally housed HIV-infected ... -
Food Insecurity as a Barrier to Sustained Antiretroviral Therapy Adherence in Uganda
Weiser, Sheri D.; Tuller, David M.; Frongillo, Edward A.; Senkungu, Jude; Mukiibi, Nozmu; Bangsberg, David Roy (Public Library of Science, 2010)Background: Food insecurity is emerging as an important barrier to antiretroviral (ARV) adherence in sub-Saharan Africa and elsewhere, but little is known about the mechanisms through which food insecurity leads to ARV ... -
Free HIV Antiretroviral Therapy Enhances Adherence among Individuals on Stable Treatment: Implications for Potential Shortfalls in Free Antiretroviral Therapy
Byakika-Tusiime, Jayne; Polley, Eric C.; Oyugi, Jessica H.; Bangsberg, David R. (Public Library of Science, 2013)Objective: To estimate the population-level causal effect of source of payment for HIV medication on treatment adherence using Marginal Structural Models. Methods: Data were obtained from an observational cohort of 76 ... -
Harnessing Poverty Alleviation to Reduce the Stigma of HIV in Sub-Saharan Africa
Tsai, Alexander C.; Bangsberg, David R.; Weiser, Sheri D. (Public Library of Science, 2013)Alexander Tsai and colleagues highlight the complex relationship between poverty and HIV stigma in sub-Saharan Africa, and discuss possible ways to break the cycle. Please see later in the article for the Editors' Summary