Now showing items 1-3 of 3

    • The C. elegans Lifespan Machine 

      Stroustrup, Nicholas; Ulmschneider, Bryne E.; Nash, Zachary M.; López Moyado, Isaac F.; Apfeld, Javier; Fontana, Walter (2013)
      The measurement of lifespan pervades aging research. Because lifespan results from complex interactions between genetic, environmental and stochastic factors, it varies widely even among isogenic individuals. The action ...
    • The C. elegans Lifespan Machine and its application to the temperature scaling of lifespan 

      Stroustrup, Nicholas Edward (2013-10-08)
      Lifespan results from the complex interaction between genetic, environmental and stochastic factors, and therefore varies widely even among isogenic individuals. In C. elegans , the action of molecular mechanisms on aging ...
    • An Insulin-to-Insulin Regulatory Network Orchestrates Phenotypic Specificity in Development and Physiology 

      Fernandes de Abreu, Diana Andrea; Caballero, Antonio; Fardel, Pascal; Stroustrup, Nicholas; Chen, Zhunan; Lee, KyungHwa; Keyes, William D.; Nash, Zachary M.; López-Moyado, Isaac F.; Vaggi, Federico; Cornils, Astrid; Regenass, Martin; Neagu, Anca; Ostojic, Ivan; Liu, Chang; Cho, Yongmin; Sifoglu, Deniz; Shen, Yu; Fontana, Walter; Lu, Hang; Csikasz-Nagy, Attila; Murphy, Coleen T.; Antebi, Adam; Blanc, Eric; Apfeld, Javier; Zhang, Yun; Alcedo, Joy; Ch'ng, QueeLim (Public Library of Science, 2014)
      Insulin-like peptides (ILPs) play highly conserved roles in development and physiology. Most animal genomes encode multiple ILPs. Here we identify mechanisms for how the forty Caenorhabditis elegans ILPs coordinate diverse ...