Browsing by Author "Fujii, Tsutomu"
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Epidermal Growth Factor Gene Functional Polymorphism and the Risk of Hepatocellular Carcinoma in Patients With Cirrhosis
Tanabe, Kenneth Kenji; Lemoine, Antoinette; Finkelstein, Dianne Madelyn; Kawasaki, Hiroshi; Fujii, Tsutomu; Chung, Raymond Taeyong; Lauwers, Gregory Y.; Kulu, Yakup; Muzikansky, Alona; Kuruppu, Darshini; Lanuti, Michael; Goodwin, Jonathan M.; Azoulay, Daniel; Fuchs, Bryan C. (American Medical Association (AMA), 2008)Context: Overexpression of epidermal growth factor (EGF) in the liver induces transformation to hepatocellular carcinoma in animal models. Polymorphisms in the EGF gene modulate EGF levels. Objective: To assess the ... -
A functional polymorphism in the epidermal growth factor gene predicts hepatocellular carcinoma risk in Japanese hepatitis C patients
Suenaga, Masaya; Yamada, Suguru; Fujii, Tsutomu; Fuchs, Bryan C; Okumura, Norio; Kanda, Mitsuro; Kobayashi, Daisuke; Tanaka, Chie; Nakayama, Goro; Sugimoto, Hiroyuki; Koike, Masahiko; Nomoto, Shuji; Fujiwara, Michitaka; Takeda, Shin; Hayashi, Kazuhiko; Tanabe, Kenneth K; Goto, Hidemi; Kodera, Yasuhiro (Dove Medical Press, 2013)Background: A single nucleotide polymorphism (SNP) in the epidermal growth factor (EGF) gene (rs4444903) has been associated with increased risk of cancer, including hepatocellular carcinoma (HCC). The aim of this study ... -
Mouse Model of Carbon Tetrachloride Induced Liver Fibrosis: Histopathological Changes and Expression of CD133 and Epidermal Growth Factor
Fujii, Tsutomu; Fuchs, Bryan C.; Yamada, Suguru; Lauwers, Gregory Y.; Kulu, Yakup; Goodwin, Jonathan M; Lanuti, Michael; Tanabe, Kenneth Kenji (BioMed Central, 2010)Background: In the setting of chronic liver injury in humans, epidermal growth factor (EGF) and EGF receptor (EGFR) are up-regulated and have been proposed to have vital roles in both liver regeneration and development of ...