Now showing items 1-6 of 6

    • Exon expression profiling reveals stimulus-mediated exon use in neural cells 

      McKee, Adrienne E; Neretti, Nicola; Carvalho, Luis E; Brodsky, Alexander S; Meyer, Clifford; Meyer, Clifford; Fox, Edward Alvin; Silver, Pamela A. (BioMed Central, 2007)
      Background: Neuronal cells respond to changes in intracellular calcium ([Ca2+]i) by affecting both the abundance and architecture of specific mRNAs. Although calcium-induced transcription and transcript variation have ...
    • Genetic Fixity in the Human Major Histocompatibility Complex and Block Size Diversity in the Class I Region Including HLA-E 

      Romero, Viviana; Romero, Tatiana; Clavijo, Olga P; Fici, Dolores A; Alford, Dennis R; Awdeh, Zuheir L; Zuñiga, Joaquin; El-Dahdah, Lama; Larsen, Charles E.; Duke-Cohan, Jonathan S.; Fox, Edward Alvin; Husain, Zaheed; Almeciga, Ingrid; Alper, Chester A.; Yunis, Edmond J. (BioMed Central, 2007)
      Background: The definition of human MHC class I haplotypes through association of HLA-A, HLA-Cw and HLA-B has been used to analyze ethnicity, population migrations and disease association. Results: Here, we present HLA-E ...
    • Genome-Wide Analysis of Neuroblastomas using High-Density Single Nucleotide Polymorphism Arrays 

      Attiyeh, Edward F.; Moreau, Lisa A.; Fortina, Paolo; Maris, John M.; George, Rani E.; Li, Shuli; Neuberg, Donna S.; Li, Cheng; Fox, Edward Alvin; Meyerson, Matthew Langer; Diller, Lisa Robin; Look, A. Thomas (Public Library of Science, 2007)
      Background: Neuroblastomas are characterized by chromosomal alterations with biological and clinical significance. We analyzed paired blood and primary tumor samples from 22 children with high-risk neuroblastoma for loss ...
    • Genomic mapping of RNA polymerase II reveals sites of co-transcriptional regulation in human cells 

      Brodsky, Alexander S; Meyer, Clifford; Swinburne, Ian A; Hall, Giles; Keenan, Benjamin J; Liu, Xiaole Shirley; Fox, Edward Alvin; Silver, Pamela A. (BioMed Central, 2005)
      Background: Transcription by RNA polymerase II is regulated at many steps including initiation, promoter release, elongation and termination. Accumulation of RNA polymerase II at particular locations across genes can be ...
    • Inferring Loss-of-Heterozygosity from Unpaired Tumors Using High-Density Oligonucleotide SNP Arrays 

      Park, Yuhyun; Hao, Ke; Zhao, Xiaojun; Mellinghoff, Ingo K; Hofer, Matthias D; Descazeaud, Aurelien; Rubin, Mark A; Sellers, William R; Bourne, Philip; Beroukhim, Rameen; Lin, Ming; Garraway, Levi Alexander; Fox, Edward Alvin; Hochberg, Ephraim Paul; Meyerson, Matthew Langer; Wong, Wing H; Li, Cheng (Public Library of Science, 2006)
      Loss of heterozygosity (LOH) of chromosomal regions bearing tumor suppressors is a key event in the evolution of epithelial and mesenchymal tumors. Identification of these regions usually relies on genotyping tumor and ...
    • Next-Generation cDNA Screening for Oncogene and Resistance Phenotypes 

      Shindoh, Nobuaki; Weigert, Oliver; Bird, Liat; Yoda, Akinori; Yoda, Yuka; Sullivan, Timothy J.; Lane, Andrew Alan; Kopp, Nadja; Rodig, Scott J.; Fox, Edward Alvin; Weinstock, David Marc (Public Library of Science, 2012)
      There is a pressing need for methods to define the functional relevance of genetic alterations identified by next-generation sequencing of cancer specimens. We developed new approaches to efficiently construct full-length ...