Browsing by Author "Mitchell, Richard"
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Cardiac Magnetic Resonance Assessment of Interstitial Myocardial Fibrosis and Cardiomyocyte Hypertrophy in Hypertensive Mice Treated With Spironolactone
Coelho‐Filho, Otavio R.; Shah, Ravi V.; Neilan, Tomas G.; Mitchell, Richard; Moreno, Heitor; Kwong, Raymond; Jerosch‐Herold, Michael (Blackwell Publishing Ltd, 2014)Background: Nearly 50% of patients with heart failure (HF) have preserved LV ejection fraction, with interstitial fibrosis and cardiomyocyte hypertrophy as early manifestations of pressure overload. However, methods to ... -
Characterization of smooth muscle-like cells in circulating human peripheral blood
Sugiyama, Seigo; Kugiyama, Kiyotaka; Nakamura, Shinichi; Kataoka, Keiichiro; Aikawa, Masanori; Shimizu, Koichi; Koide, Shunichi; Mitchell, Richard Neal; Ogawa, Hisao; Libby, Peter (Elsevier BV, 2006)Smooth muscle cells play an important role in human vascular diseases. Several lines of evidence demonstrate that circulating smooth muscle precursor cells contribute to intimal hyperplasia in animal models. We obtained ... -
Interferon-gamma deficiency prevents coronary arteriosclerosis but not myocardial rejection in transplanted mouse hearts
Nagano, H; Mitchell, Richard Neal; Taylor, M K; Hasegawa, S; Tilney, N L; Libby, Peter (American Society for Clinical Investigation, 1997)We have hypothesized that T cell cytokines participate in the pathogenesis of graft arterial disease (GAD). This study tested the consequences of IFN-gamma deficiency on arterial and parenchymal pathology in murine cardiac ... -
A Sensitive Chemotaxis Assay Using a Novel Microfluidic Device
Zhang, Chen; Jang, Sunyoung; Amadi, Ovid C.; Shimizu, Koichi; Lee, Richard T.; Mitchell, Richard N. (Hindawi Publishing Corporation, 2013)Existing chemotaxis assays do not generate stable chemotactic gradients and thus—over time—functionally measure only nonspecific random motion (chemokinesis). In comparison, microfluidic technology has the capacity to ... -
Th2-predominant inflammation and blockade of IFN-γ signaling induce aneurysms in allografted aortas
Shimizu, Koichi; Shichiri, Masayoshi; Libby, Peter; Lee, Richard Theodore; Mitchell, Richard Neal (American Society for Clinical Investigation, 2004)Abdominal aortic aneurysms (AAAs) cause death due to complications related to expansion and rupture. The underlying mechanisms that drive AAA development remain largely unknown. We recently described evidence for a shift ... -
Tumor Necrosis Factor Receptor -1 and -2 Double Deficiency Reduces Graft Arterial Disease in Murine Cardiac Allografts
Suzuki, Jun-ichi; Cole, Sarah E.; Batirel, Saime; Kosuge, Hisanori; Shimizu, Koichi; Isobe, Mitsuaki; Libby, Peter; Mitchell, Richard Neal (Wiley-Blackwell, 2003)Graft arterial disease (GAD) remains the leading cause of long‐term solid organ allograft failure. Tumor necrosis factor (TNF) promotes multiple aspects of allograft rejection via binding to type 1 (p55) and type 2 (p75) ...