Browsing by Author "Van Dam, Rob"

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    • Acute Effects of Decaffeinated Coffee and the Major Coffee Components Chlorogenic Acid and Trigonelline on Glucose Tolerance 

      van Dijk, Aimée E.; Olthof, Margreet R.; Meeuse, Joke C.; Seebus, Elin; Heine, Rob J.; van Dam, Rob M. (American Diabetes Association, 2009)
      OBJECTIVE: Coffee consumption has been associated with lower risk of type 2 diabetes. We evaluated the acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on glucose ...

    • Association of Television Viewing Time with Body Composition and Calcified Subclinical Atherosclerosis in Singapore Chinese 

      Nang, Ei Ei Khaing; van Dam, Rob M.; Tan, Chuen Seng; Mueller-Riemenschneider, Falk; Lim, Yi Ting; Ong, Kai Zhi; Ee, Siqing; Lee, Jeannette; Tai, E. Shyong (Public Library of Science, 2015)
      Objective: Sedentary behavior such as television viewing may be an independent risk factor for coronary heart disease. However, few studies have assessed the impact of television viewing time on coronary artery calcification ...

    • Cholesterol-Raising Diterpenes in Types of Coffee Commonly Consumed in Singapore, Indonesia and India and Associations with Blood Lipids: A Survey and Cross Sectional Study 

      Naidoo, Nasheen; Chen, Cynthia; Rebello, Salome A.; Speer, Karl; Tai, E. Shyong; Lee, Jeanette; Buchmann, Sandra; Koelling-Speer, Isabelle; van Dam, Rob M. (BioMed Central, 2011)
      Background: To measure the content of cholesterol-raising diterpenes in coffee sold at the retailer level in Singapore, Indonesia and India and to determine the relationship of coffee consumption with lipid levels in a ...

    • Coffee Consumption and Risk of Cardiovascular Diseases and All-Cause Mortality Among Men With Type 2 Diabetes 

      Zhang, Weili; Lopez-Garcia, Esther; Li, Tricia Y.; Hu, Frank B.; van Dam, Rob M. (American Diabetes Association, 2009)
      OBJECTIVE: Coffee consumption has been linked to detrimental acute metabolic and hemodynamic effects. We investigated coffee consumption in relation to risk of CVDs and mortality in diabetic men. RESEARCH DESIGN AND METHODS: ...

    • Combined impact of lifestyle factors on mortality: prospective cohort study in US women 

      van Dam, Rob M.; Li, Tricia; Spiegelman, Donna Lynn; Franco, Oscar H; Hu, Frank B. (BMJ Publishing Group Ltd., 2008)
      Objective: To evaluate the impact of combinations of lifestyle factors on mortality in middle aged women. Design: Prospective cohort study. Setting: Nurses’ health study, United States. Participants: 77 782 women aged 34 ...

    • Development of a Semi-Quantitative Food Frequency Questionnaire to Assess the Dietary Intake of a Multi-Ethnic Urban Asian Population 

      Neelakantan, Nithya; Whitton, Clare; Seah, Sharna; Koh, Hiromi; Rebello, Salome A.; Lim, Jia Yi; Chen, Shiqi; Chan, Mei Fen; Chew, Ling; van Dam, Rob M. (MDPI, 2016)
      Assessing habitual food consumption is challenging in multi-ethnic cosmopolitan settings. We systematically developed a semi-quantitative food frequency questionnaire (FFQ) in a multi-ethnic population in Singapore, using ...

    • Dietary Patterns during Adolescence and Risk of Type 2 Diabetes in Middle-Aged Women 

      Malik, Vasanti; Fung, Teresa Toiyee; van Dam, Rob M.; Rimm, Eric B.; Rosner, Bernard Alfred; Hu, Frank B. (American Diabetes Association, 2012)
      Objective: Whether dietary habits early in life can affect risk of type 2 diabetes (T2DM) in adulthood is unknown. We evaluated the relationship between dietary patterns during adolescence and risk of T2DM in midlife. ...

    • Effect of fenugreek (Trigonella foenum-graecum L.) intake on glycemia: a meta-analysis of clinical trials 

      Neelakantan, Nithya; Narayanan, Madanagopal; de Souza, Russell J; van Dam, Rob M (BioMed Central, 2014)
      Background and aim Fenugreek is a herb that is widely used in cooking and as a traditional medicine for diabetes in Asia. It has been shown to acutely lower postprandial glucose levels, but the long-term effect on glycemia ...

    • The Effects of Caffeinated and Decaffeinated Coffee on Sex Hormone-Binding Globulin and Endogenous Sex Hormone Levels: A Randomized Controlled Trial 

      Wedick, Nicole Marie; Mantzoros, Christos; Ding, Eric L.; Brennan, Aoife M; Rosner, Bernard Alfred; Rimm, Eric B.; Hu, Frank B.; van Dam, Rob M. (BioMed Central, 2012)
      Background: Findings from observational studies suggest that sex hormone-binding globulin (SHBG) and endogenous sex hormones may be mediators of the putative relation between coffee consumption and lower risk of type 2 ...

    • Fat Mass–and Obesity-Associated (FTO) Gene Variant Is Associated With Obesity 

      Qi, Lu; Kang, Kihwa; Zhang, Cuilin; van Dam, Rob M.; Kraft, Peter; Hunter, David; Lee, Chih-Hao; Hu, Frank B. (American Diabetes Association, 2008)
      OBJECTIVE—To examine the longitudinal association of fat mass–and obesity-associated (FTO) variant with obesity, circulating adipokine levels, and FTO expression in various materials from human and mouse. RESEARCH DESIGN ...

    • Fruit consumption and risk of type 2 diabetes: results from three prospective longitudinal cohort studies 

      Muraki, Isao; Imamura, Fumiaki; Manson, JoAnn E; Hu, Frank B; Willett, Walter C; van Dam, Rob M; Sun, Qi (BMJ Publishing Group Ltd., 2013)
      Objective: To determine whether individual fruits are differentially associated with risk of type 2 diabetes. Design: Prospective longitudinal cohort study. Setting: Health professionals in the United States. Participants: ...

    • Genetic fine-mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci 

      Gaulton, Kyle J; Ferreira, Teresa; Lee, Yeji; Raimondo, Anne; Mägi, Reedik; Reschen, Michael E; Mahajan, Anubha; Locke, Adam; Rayner, N William; Robertson, Neil; Scott, Robert A; Prokopenko, Inga; Scott, Laura J; Green, Todd; Sparso, Thomas; Thuillier, Dorothee; Yengo, Loic; Grallert, Harald; Wahl, Simone; Frånberg, Mattias; Strawbridge, Rona J; Kestler, Hans; Chheda, Himanshu; Eisele, Lewin; Gustafsson, Stefan; Steinthorsdottir, Valgerdur; Thorleifsson, Gudmar; Qi, Lu; Karssen, Lennart C; van Leeuwen, Elisabeth M; Willems, Sara M; Li, Man; Chen, Han; Fuchsberger, Christian; Kwan, Phoenix; Ma, Clement; Linderman, Michael; Lu, Yingchang; Thomsen, Soren K; Rundle, Jana K; Beer, Nicola L; van de Bunt, Martijn; Chalisey, Anil; Kang, Hyun Min; Voight, Benjamin F; Abecasis, Goncalo R; Almgren, Peter; Baldassarre, Damiano; Balkau, Beverley; Benediktsson, Rafn; Blüher, Matthias; Boeing, Heiner; Bonnycastle, Lori L; Borringer, Erwin P; Burtt, Noël P; Carey, Jason; Charpentier, Guillaume; Chines, Peter S; Cornelis, Marilyn C; Couper, David J; Crenshaw, Andrew T; van Dam, Rob M; Doney, Alex SF; Dorkhan, Mozhgan; Edkins, Sarah; Eriksson, Johan G; Esko, Tonu; Eury, Elodie; Fadista, João; Flannick, Jason; Fontanillas, Pierre; Fox, Caroline; Franks, Paul W; Gertow, Karl; Gieger, Christian; Gigante, Bruna; Gottesman, Omri; Grant, George B; Grarup, Niels; Groves, Christopher J; Hassinen, Maija; Have, Christian T; Herder, Christian; Holmen, Oddgeir L; Hreidarsson, Astradur B; Humphries, Steve E; Hunter, David J; Jackson, Anne U; Jonsson, Anna; Jørgensen, Marit E; Jørgensen, Torben; Kao, Wen-Hong L; Kerrison, Nicola D; Kinnunen, Leena; Klopp, Norman; Kong, Augustine; Kovacs, Peter; Kraft, Peter; Kravic, Jasmina; Langford, Cordelia; Leander, Karin; Liang, Liming; Lichtner, Peter; Lindgren, Cecilia M; Lindholm, Eero; Linneberg, Allan; Liu, Ching-Ti; Lobbens, Stéphane; Luan, Jian’an; Lyssenko, Valeriya; Mӓnnistö, Satu; McLeod, Olga; Meyer, Julia; Mihailov, Evelin; Mirza, Ghazala; Mühleisen, Thomas W; Müller-Nurasyid, Martina; Navarro, Carmen; Nöthen, Markus M; Oskolkov, Nikolay N; Owen, Katharine R; Palli, Domenico; Pechlivanis, Sonali; Peltonen, Leena; Perry, John RB; Platou, Carl GP; Roden, Michael; Ruderfer, Douglas; Rybin, Denis; van der Schouw, Yvonne T; Sennblad, Bengt; Sigurđsson, Gunnar; Stančáková, Alena; Steinbach, Gerald; Storm, Petter; Strauch, Konstantin; Stringham, Heather M; Sun, Qi; Thorand, Barbara; Tikkanen, Emmi; Tonjes, Anke; Trakalo, Joseph; Tremoli, Elena; Tuomi, Tiinamaija; Wennauer, Roman; Wiltshire, Steven; Wood, Andrew R; Zeggini, Eleftheria; Dunham, Ian; Birney, Ewan; Pasquali, Lorenzo; Ferrer, Jorge; Loos, Ruth JF; Dupuis, Josée; Florez, Jose C; Boerwinkle, Eric; Pankow, James S; van Duijn, Cornelia; Sijbrands, Eric; Meigs, James B; Hu, Frank B; Thorsteinsdottir, Unnur; Stefansson, Kari; Lakka, Timo A; Rauramaa, Rainer; Stumvoll, Michael; Pedersen, Nancy L; Lind, Lars; Keinanen-Kiukaanniemi, Sirkka M; Korpi-Hyövӓlti, Eeva; Saaristo, Timo E; Saltevo, Juha; Kuusisto, Johanna; Laakso, Markku; Metspalu, Andres; Erbel, Raimund; Jöckel, Karl-Heinz; Moebus, Susanne; Ripatti, Samuli; Salomaa, Veikko; Ingelsson, Erik; Boehm, Bernhard O; Bergman, Richard N; Collins, Francis S; Mohlke, Karen L; Koistinen, Heikki; Tuomilehto, Jaakko; Hveem, Kristian; Njølstad, Inger; Deloukas, Panagiotis; Donnelly, Peter J; Frayling, Timothy M; Hattersley, Andrew T; de Faire, Ulf; Hamsten, Anders; Illig, Thomas; Peters, Annette; Cauchi, Stephane; Sladek, Rob; Froguel, Philippe; Hansen, Torben; Pedersen, Oluf; Morris, Andrew D; Palmer, Collin NA; Kathiresan, Sekar; Melander, Olle; Nilsson, Peter M; Groop, Leif C; Barroso, Inês; Langenberg, Claudia; Wareham, Nicholas J; O’Callaghan, Christopher A; Gloyn, Anna L; Altshuler, David; Boehnke, Michael; Teslovich, Tanya M; McCarthy, Mark I; Morris, Andrew P (2015)
      We performed fine-mapping of 39 established type 2 diabetes (T2D) loci in 27,206 cases and 57,574 controls of European ancestry. We identified 49 distinct association signals at these loci, including five mapping in/near ...

    • A genome-wide association study of early menopause and the combined impact of identified variants 

      Perry, John R. B.; Corre, Tanguy; Esko, Tõnu; Chasman, Daniel Ian; Fischer, Krista; Franceschini, Nora; He, Chunyan; Kutalik, Zoltan; Mangino, Massimo; Rose, Lynda M.; Vernon Smith, Albert; Stolk, Lisette; Sulem, Patrick; Weedon, Michael N.; Zhuang, Wei V.; Arnold, Alice; Ashworth, Alan; Bergmann, Sven; Buring, Julie Elizabeth; Burri, Andrea; Chen, Constance; Cornelis, Marilyn; Couper, David J.; Goodarzi, Mark O.; Gudnason, Vilmundur; Harris, Tamara; Hofman, Albert; Jones, Michael; Kraft, Phillip L.; Launer, Lenore; Laven, Joop S. E.; Li, Guoan; McKnight, Barbara; Masciullo, Corrado; Milani, Lili; Orr, Nicholas; Psaty, Bruce M.; Ridker, Paul M.; Rivadeneira, Fernando; Sala, Cinzia; Salumets, Andres; Schoemaker, Minouk; Traglia, Michela; Waeber, Gérard; Chanock, Stephen J.; Demerath, Ellen W.; Garcia, Melissa; Hankinson, Susan Elizabeth; Hu, Frank B.; Hunter, David J.; Lunetta, Kathryn L.; Metspalu, Andres; Montgomery, Grant W.; Murabito, Joanne M.; Newman, Anne B.; Ong, Ken K.; Spector, Tim D.; Stefansson, Kari; Swerdlow, Anthony J.; Thorsteinsdottir, Unnur; van Dam, Rob M.; Uitterlinden, André G.; Visser, Jenny A.; Vollenweider, Peter; Toniolo, Daniela; Murray, Anna (Oxford University Press, 2013)
      Early menopause (EM) affects up to 10% of the female population, reducing reproductive lifespan considerably. Currently, it constitutes the leading cause of infertility in the western world, affecting mainly those women ...

    • Large-Scale Association Analysis Provides Insights into the Genetic Architecture and Pathophysiology of Type 2 Diabetes 

      Morris, Andrew P; Voight, Benjamin F; Teslovich, Tanya M; Ferreira, Teresa; Segré, Ayellet V; Steinthorsdottir, Valgerdur; Strawbridge, Rona J; Khan, Hassan; Grallert, Harald; Mahajan, Anubha; Prokopenko, Inga; Kang, Hyun Min; Dina, Christian; Esko, Tonu; Fraser, Ross M; Kanoni, Stavroula; Kumar, Ashish; Lagou, Vasiliki; Langenberg, Claudia; Luan, Jian’an; Lindgren, Cecilia M; Müller-Nurasyid, Martina; Pechlivanis, Sonali; Rayner, N William; Scott, Laura J; Wiltshire, Steven; Yengo, Loic; Kinnunen, Leena; Rossin, Elizabeth J; Raychaudhuri, Soumya; Johnson, Andrew D; Dimas, Antigone S; Loos, Ruth J F; Vedantam, Sailaja; Chen, Han; Florez, Jose Carlos; Fox, Caroline; Liu, Ching-Ti; Rybin, Denis; Couper, David J; Kao, Wen Hong L; Li, Man; Cornelis, Marilyn; Kraft, Peter Elias; Sun, Qi; van Dam, Rob M; Stringham, Heather M; Chines, Peter S; Fischer, Krista; Fontanillas, Pierre; Holmen, Oddgeir L; Hunt, Sarah E; Jackson, Anne U; Kong, Augustine; Lawrence, Robert; Meyer, Julia; Perry, John R B; Platou, Carl G P; Potter, Simon; Rehnberg, Emil; Robertson, Neil; Sivapalaratnam, Suthesh; Stančáková, Alena; Stirrups, Kathleen; Thorleifsson, Gudmar; Tikkanen, Emmi; Wood, Andrew R; Almgren, Peter; Atalay, Mustafa; Benediktsson, Rafn; Bonnycastle, Lori L; Burtt, Noël; Carey, Jason; Charpentier, Guillaume; Crenshaw, Andrew T; Doney, Alex S F; Dorkhan, Mozhgan; Edkins, Sarah; Emilsson, Valur; Eury, Elodie; Forsen, Tom; Gertow, Karl; Gigante, Bruna; Grant, George B; Groves, Christopher J; Guiducci, Candace; Herder, Christian; Hreidarsson, Astradur B; Hui, Jennie; James, Alan; Jonsson, Anna; Rathmann, Wolfgang; Klopp, Norman; Kravic, Jasmina; Krjutškov, Kaarel; Langford, Cordelia; Leander, Karin; Lindholm, Eero; Lobbens, Stéphane; Männistö, Satu; Mirza, Ghazala; Mühleisen, Thomas W; Musk, Bill; Parkin, Melissa Ann; Rallidis, Loukianos; Saramies, Jouko; Sennblad, Bengt; Shah, Sonia; Sigurðsson, Gunnar; Silveira, Angela; Steinbach, Gerald; Thorand, Barbara; Trakalo, Joseph; Veglia, Fabrizio; Wennauer, Roman; Winckler, Wendy; Zabaneh, Delilah; Campbell, Harry; van Duijn, Cornelia; Uitterlinden, Andre G; Hofman, Albert; Sijbrands, Eric; Abecasis, Goncalo R; Owen, Katharine R; Zeggini, Eleftheria; Trip, Mieke D; Forouhi, Nita G; Syvänen, Ann-Christine; Eriksson, Johan G; Peltonen, Leena; Nöthen, Markus M; Balkau, Beverley; Palmer, Colin N A; Lyssenko, Valeriya; Tuomi, Tiinamaija; Isomaa, Bo; Hunter, David J.; Qi, Lu; Shuldiner, Alan R; Roden, Michael; Barroso, Ines; Wilsgaard, Tom; Beilby, John; Hovingh, Kees; Price, Jackie F; Wilson, James F; Rauramaa, Rainer; Lakka, Timo A; Lind, Lars; Dedoussis, George; Njølstad, Inger; Pedersen, Nancy L; Khaw, Kay-Tee; Wareham, Nicholas J; Keinanen-Kiukaanniemi, Sirkka M; Saaristo, Timo E; Korpi-Hyövälti, Eeva; Saltevo, Juha; Laakso, Markku; Kuusisto, Johanna; Metspalu, Andres; Collins, Francis S; Mohlke, Karen L; Bergman, Richard N; Tuomilehto, Jaakko; Boehm, Bernhard O; Gieger, Christian; Hveem, Kristian; Cauchi, Stephane; Froguel, Philippe; Baldassarre, Damiano; Tremoli, Elena; Humphries, Steve E; Saleheen, Danish; Danesh, John; Ingelsson, Erik; Ripatti, Samuli; Salomaa, Veikko; Erbel, Raimund; Jöckel, Karl-Heinz; Moebus, Susanne; Peters, Annette; Illig, Thomas; de Faire, Ulf; Hamsten, Anders; Morris, Andrew D; Donnelly, Peter J; Frayling, Timothy M; Hattersley, Andrew T; Boerwinkle, Eric; Melander, Olle; Kathiresan, Sekar; Nilsson, Peter M; Deloukas, Panos; Thorsteinsdottir, Unnur; Groop, Leif C; Stefansson, Kari; Hu, Frank B.; Pankow, James S; Dupuis, Josée; Meigs, James Benjamin; Altshuler, David Matthew; Boehnke, Michael; McCarthy, Mark I (Nature Publishing Group, 2012)
      To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip involving 34,840 cases and 114,981 controls, overwhelmingly ...

    • Maternal caffeine intake during pregnancy is associated with risk of low birth weight: a systematic review and dose–response meta-analysis 

      Chen, Ling-Wei; Wu, Yi; Neelakantan, Nithya; Chong, Mary Foong-Fong; Pan, An; van Dam, Rob M (BioMed Central, 2014)
      Background: Considerable controversy exists regarding the relation between maternal caffeine intake during pregnancy and risk of low birth weight (birth weight <2,500 g). We aim to assess this association using a systematic ...

    • Maternal Plasma 25-Hydroxyvitamin D Concentrations and the Risk for Gestational Diabetes Mellitus 

      Zhang, Cuilin; Qiu, Chunfang; Hu, Frank B.; David, Robert M.; van Dam, Rob M.; Bralley, Alexander; Williams, Michelle A. (Public Library of Science, 2008)
      Background: Evidence is accumulating for a role of vitamin D in maintaining normal glucose homeostasis. However, studies that prospectively examined circulating concentrations of 25-hydroxyvitamin D (25-[OH] D) in relation ...

    • Obesity susceptibility loci and uncontrolled eating, emotional eating and cognitive restraint behaviors in men and women 

      Cornelis, Marilyn C.; Rimm, Eric B.; Curhan, Gary C.; Kraft, Peter; Hunter, David J.; Hu, Frank B.; van Dam, Rob M. (2013)
      Objective: Many confirmed genetic loci for obesity are expressed in regions of the brain that regulate energy intake and reward-seeking behavior. Whether these loci contribute to the development of specific eating behaviors ...

    • Physical Activity Before and During Pregnancy and Risk of Gestational Diabetes Mellitus: A Meta-Analysis 

      Tobias, Deirdre Kay; Zhang, Cuilin; van Dam, Rob M.; Bowers, Katherine; Hu, Frank B. (American Diabetes Association, 2011)
      OBJECTIVE: Gestational diabetes mellitus (GDM) is one of the most common complications of pregnancy and is associated with a substantially elevated risk of adverse health outcomes for both mothers and offspring. Physical ...

    • Prospective Study of Zinc Intake and Risk of Type 2 Diabetes in Women 

      Sun, Qi; van Dam, Rob M.; Willett, Walter C.; Hu, Frank B. (American Diabetes Association, 2009)
      OBJECTIVE: The aim of this study is to investigate the intake of zinc in relation to risk of type 2 diabetes in U.S. women. RESEARCH DESIGN AND METHODS: Dietary intakes of zinc and other nutrients were assessed and updated ...

    • Sociodemographic, home environment and parental influences on total and device-specific screen viewing in children aged 2 years and below: an observational study 

      Goh, Si Ning; Teh, Long Hua; Tay, Wei Rong; Anantharaman, Saradha; van Dam, Rob M; Tan, Chuen Seng; Chua, Hwee Ling; Wong, Pey Gein; Müller-Riemenschneider, Falk (BMJ Publishing Group, 2016)
      Objective: This study aimed to investigate total and device-specific screen viewing (SV) and its determinants in children aged 2 years and below. Design: Cross-sectional study conducted in February 2014. Setting: Well-child ...