Browsing by Author "Eskandar, Emad"

Now showing items 1-13 of 13

    • Action Initiation in the Human Dorsal Anterior Cingulate Cortex 

      Srinivasan, Lakshminarayan; Asaad, Wael F.; Ginat, Daniel T; Gale, John T.; Dougherty, Darin Dean; Williams, Ziv; Sejnowski, Terrence J.; Eskandar, Emad (Public Library of Science, 2013)
      The dorsal anterior cingulate cortex (dACC) has previously been implicated in processes that influence action initiation. In humans however, there has been little direct evidence connecting dACC to the temporal onset of ...

    • Consensus on guidelines for stereotactic neurosurgery for psychiatric disorders 

      Nuttin, Bart; Wu, Hemmings; Mayberg, Helen; Hariz, Marwan; Gabriëls, Loes; Galert, Thorsten; Merkel, Reinhard; Kubu, Cynthia; Vilela-Filho, Osvaldo; Matthews, Keith; Taira, Takaomi; Lozano, Andres M; Schechtmann, Gastón; Doshi, Paresh; Broggi, Giovanni; Régis, Jean; Alkhani, Ahmed; Sun, Bomin; Eljamel, Sam; Schulder, Michael; Kaplitt, Michael; Eskandar, Emad; Rezai, Ali; Krauss, Joachim K; Hilven, Paulien; Schuurman, Rick; Ruiz, Pedro; Chang, Jin Woo; Cosyns, Paul; Lipsman, Nir; Voges, Juergen; Cosgrove, Rees; Li, Yongjie; Schlaepfer, Thomas (BMJ Publishing Group, 2014)
      Background: For patients with psychiatric illnesses remaining refractory to ‘standard’ therapies, neurosurgical procedures may be considered. Guidelines for safe and ethical conduct of such procedures have previously and ...

    • Deep brain stimulation for medically refractory life-threatening status dystonicus in children 

      Walcott, Brian; Nahed, Brian Vala; Kahle, Kristopher; Duhaime, Ann-Christine; Sharma, Nutan; Eskandar, Emad (Journal of Neurosurgery Publishing Group (JNSPG), 2012)
      Generalized dystonic syndromes may escalate into persistent episodes of generalized dystonia known as status dystonicus that can be life-threatening due to dystonia-induced rhabdomyolysis and/or respiratory compromise. ...

    • The effects of cues on neurons in the basal ganglia in Parkinson's disease 

      Sarma, Sridevi V.; Cheng, Ming L.; Eden, Uri; Williams, Ziv; Brown, Emery Neal; Eskandar, Emad (Frontiers Media S.A., 2012)
      Visual cues open a unique window to the understanding of Parkinson's disease (PD). These cues can temporarily but dramatically improve PD motor symptoms. Although details are unclear, cues are believed to suppress pathological ...

    • Hippocampography Guides Consistent Mesial Resections in Neocortical Temporal Lobe Epilepsy 

      Ng, Marcus C.; Kilbride, Ronan; Simon, Mirela; Eskandar, Emad; Cole, Andrew J. (Hindawi Publishing Corporation, 2016)
      Background. The optimal surgery in lesional neocortical temporal lobe epilepsy is unknown. Hippocampal electrocorticography maximizes seizure freedom by identifying normal-appearing epileptogenic tissue for resection and ...

    • Human seizures self-terminate across spatial scales via a critical transition 

      Kramer, M. A.; Truccolo, W.; Eden, U. T.; Lepage, K. Q.; Hochberg, Leigh Robert; Eskandar, Emad; Madsen, Joseph Russell; Lee, Jong Woo; Maheshwari, A.; Halgren, E.; Chu, Catherine Jean; Cash, Sydney S. (Proceedings of the National Academy of Sciences, 2012)
      Why seizures spontaneously terminate remains an unanswered fundamental question of epileptology. Here we present evidence that seizures self-terminate via a discontinuous critical transition or bifurcation. We show that ...

    • Local cortical dynamics of burst suppression in the anaesthetized brain 

      Lewis, Laura D.; Ching, ShiNung; Weiner, Veronica S.; Peterfreund, Robert A.; Eskandar, Emad N.; Cash, Sydney S.; Brown, Emery N.; Purdon, Patrick L. (Oxford University Press, 2013)
      Burst suppression is an electroencephalogram pattern that consists of a quasi-periodic alternation between isoelectric ‘suppressions’ lasting seconds or minutes, and high-voltage ‘bursts’. It is characteristic of a profoundly ...

    • Multi-tensor investigation of orbitofrontal cortex tracts affected in subcaudate tractotomy 

      Yang, Jimmy Chen; Papadimitriou, George; Eckbo, Ryan; Yeterian, Edward H.; Liang, Lichen; Dougherty, Darin Dean; Bouix, Sylvain; Rathi, Yogesh; Shenton, Martha Elizabeth; Kubicki, Marek R.; Eskandar, Emad; Makris, Nikos (Springer Science + Business Media, 2014)
      Subcaudate tractotomy (SCT) is a neurosurgical lesioning procedure that can reduce symptoms in medically intractable obsessive compulsive disorder (OCD). Due to the putative importance the orbitofrontal cortex (OFC) in ...

    • Neural population dynamics in human motor cortex during movements in people with ALS 

      Pandarinath, Chethan; Gilja, Vikash; Blabe, Christine H; Nuyujukian, Paul; Sarma, Anish A; Sorice, Brittany L; Eskandar, Emad N; Hochberg, Leigh R; Henderson, Jaimie M; Shenoy, Krishna V (eLife Sciences Publications, Ltd, 2015)
      The prevailing view of motor cortex holds that motor cortical neural activity represents muscle or movement parameters. However, recent studies in non-human primates have shown that neural activity does not simply represent ...

    • A Novel Brain Stimulation Technology Provides Compatibility with MRI 

      Serano, Peter; Angelone, Leonardo M.; Katnani, Husam; Eskandar, Emad; Bonmassar, Giorgio (Nature Publishing Group, 2015)
      Clinical electrical stimulation systems — such as pacemakers and deep brain stimulators (DBS) — are an increasingly common therapeutic option to treat a large range of medical conditions. Despite their remarkable success, ...

    • Reward and reinforcement activity in the nucleus accumbens during learning 

      Gale, John T.; Shields, Donald C.; Ishizawa, Yumiko; Eskandar, Emad N. (Frontiers Media S.A., 2014)
      The nucleus accumbens core (NAcc) has been implicated in learning associations between sensory cues and profitable motor responses. However, the precise mechanisms that underlie these functions remain unclear. We recorded ...

    • The Spatiotemporal Dynamics of Oscillatory Activity in Humans Across Micro, Meso, and Macro Scales 

      Borzello, Mia; Chu, Catherine Jean; Ebrahim, S; Eskandar, Emad; Golby, Alexandra Jacqueline; Madsen, Joseph Russell; Andersen, W; Lee, Jane; Doyle, W; Thesen, T; Cash, Sydney S. (2016-11-16)
      Brain activity is characterized by oscillatory activity that spans at least two orders of magnitude. Previous investigations of the spatiotemporal dynamics of this wide range of oscillatory behavior has led to the concept ...

    • Temporally Coordinated Deep Brain Stimulation in the Dorsal and Ventral Striatum Synergistically Enhances Associative Learning 

      Katnani, Husam A.; Patel, Shaun R.; Kwon, Churl-Su; Abdel-Aziz, Samer; Gale, John T.; Eskandar, Emad N. (Nature Publishing Group, 2016)
      The primate brain has the remarkable ability of mapping sensory stimuli into motor behaviors that can lead to positive outcomes. We have previously shown that during the reinforcement of visual-motor behavior, activity in ...