Browsing by Author "Luc, Sidinh"
Now showing items 1-2 of 2
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BCL11A Enhancer Dissection by Cas9-Mediated in Situ Saturating Mutagenesis
Canver, Matthew Charles; Smith, Elenoe; Pinello, Luca; Sanjana, Neville E.; Shalem, Ophir; Chen, Diane; Schupp, Patrick G.; Vinjamur, Divya S.; Garcia, Sara P.; Luc, Sidinh; Kurita, Ryo; Fujiwara, Yuko; Maeda, Takahiro; Yuan, Guo-Cheng; Zhang, Feng; Orkin, Stuart Holland; Bauer, Daniel Evan; Nakamura, Yukio (Nature, 2015-09-16) -
Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation
Kerenyi, Marc A; Shao, Zhen; Hsu, Yu-Jung; Guo, Guoji; Luc, Sidinh; O'Brien, Kassandra; Fujiwara, Yuko; Peng, Cong; Nguyen, Minh; Orkin, Stuart H (eLife Sciences Publications, Ltd, 2013)Here, we describe that lysine-specific demethylase 1 (Lsd1/KDM1a), which demethylates histone H3 on Lys4 or Lys9 (H3K4/K9), is an indispensible epigenetic governor of hematopoietic differentiation. Integrative genomic ...