Browsing by Author "Kobayashi, Tatsuya"

Now showing items 1-4 of 4

    • Adenomatous Polyposis Coli-mediated Control of β-catenin is Essential for Both Chondrogenic and Osteogenic Differentiation of Skeletal Precursors 

      Miclea, Razvan L; Karperien, Marcel; Bosch, Cathy AJ; van der Horst, Geertje; van der Valk, Martin A; Rawadi, Georges; Akçakaya, Pinar; Löwik, Clemens WGM; Fodde, Riccardo; Wit, Jan Maarten; Robanus-Maandag, Els C; Kobayashi, Tatsuya; Kronenberg, Henry Morris (BioMed Central, 2009)
      Background: During skeletogenesis, protein levels of β-catenin in the canonical Wnt signaling pathway determine lineage commitment of skeletal precursor cells to osteoblasts and chondrocytes. Adenomatous polyposis coli ...

    • PCSK5 mutation in a patient with the VACTERL association 

      Nakamura, Yukio; Kikugawa, Shingo; Seki, Shoji; Takahata, Masahiko; Iwasaki, Norimasa; Terai, Hidetomi; Matsubara, Mitsuhiro; Fujioka, Fumio; Inagaki, Hidehito; Kobayashi, Tatsuya; Kimura, Tomoatsu; Kurahashi, Hiroki; Kato, Hiroyuki (BioMed Central, 2015)
      Background: The VACTERL association is a typically sporadic, non-random collection of congenital anomalies that includes vertebral defects, anal atresia, cardiac defects, tracheoesophageal fistula with esophageal atresia, ...

    • Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signalling 

      Mirzamohammadi, Fatemeh; Papaioannou, Garyfallia; Inloes, Jennifer B.; Rankin, Erinn B.; Xie, Huafeng; Schipani, Ernestina; Orkin, Stuart H.; Kobayashi, Tatsuya (Nature Publishing Group, 2016)
      Polycomb repressive complex 2 (PRC2) controls maintenance and lineage determination of stem cells by suppressing genes that regulate cellular differentiation and tissue development. However, the role of PRC2 in lineage-committed ...

    • Ras signaling regulates osteoprogenitor cell proliferation and bone formation 

      Papaioannou, Garyfallia; Mirzamohammadi, Fatemeh; Kobayashi, Tatsuya (Nature Publishing Group, 2016)
      During endochondral bone development, osteoblasts are continuously differentiated from locally residing progenitor cells. However, the regulation of such endogenous osteoprogenitor cells is still poorly understood mainly ...