Browsing by Author "Hendrickson, David Gillis"

Now showing items 1-4 of 4

    • Long Noncoding RNAs Regulate Adipogenesis 

      Sun, Lei; Goff, Loyal Andrew; Trapnell, Cole; Alexander, Ryan Kendall; Lo, Kinyui Alice; Hacisuleyman, Ezgi; Sauvageau, Martin; Tazon-Vega, Barbara; Kelley, David Roy; Hendrickson, David Gillis; Yuan, Bingbing; Kellis, Manolis; Lodish, Harvey F.; Rinn, John L (Proceedings of the National Academy of Sciences, 2013)
      The prevalence of obesity has led to a surge of interest in understanding the detailed mechanisms underlying adipocyte development. Many protein-coding genes, mRNAs, and microRNAs have been implicated in adipocyte development, ...

    • Programming human pluripotent stem cells into white and brown adipocytes 

      Ahfeldt, Tim; Schinzel, Robert T.; Lee, Youn-Kyoung; Hendrickson, David Gillis; Kaplan, Adam; Lum, David H.; Camahort, Raymond; Xia, Fang; Shay, Jennifer B.; Rhee, Eugene Park; Clish, Clary B.; Deo, Rahul C.; Shen, Tony; Lau, Frank; Cowley, Alicia; Mowrer, Greg; Al-Siddiqi, Heba; Nahrendorf, Matthias; Musunuru, Kiran; Gerszten, Robert Edgardo; Rinn, John L; Cowan, Chad A. (Nature Publishing Group, 2012)
      The utility of human pluripotent stem cells is dependent on efficient differentiation protocols that convert these cells into relevant adult cell types. Here we report the robust and efficient differentiation of human ...

    • Topological Organization of Multi-chromosomal Regions by Firre 

      Hacisuleyman, Ezgi; Goff, Loyal A.; Trapnell, Cole; Williams, Adam; Henao-Mejia, Jorge; Sun, Lei; McClanahan, Patrick; Hendrickson, David G.; Sauvageau, Martin; Kelley, David R.; Morse, Michael; Engreitz, Jesse; Lander, Eric S.; Guttman, Mitch; Lodish, Harvey F.; Flavell, Richard; Raj, Arjun; Rinn, John L. (2014)
      RNA is known to be an abundant and important structural component of the nuclear matrix, including long noncoding RNAs (lncRNA). Yet the molecular identities, functional roles, and localization dynamics of lncRNAs that ...

    • Transposable elements modulate human RNA abundance and splicing via specific RNA-protein interactions 

      Kelley, David R; Hendrickson, David G; Tenen, Danielle; Rinn, John L (BioMed Central, 2014)
      Background: Transposable elements (TEs) have significantly influenced the evolution of transcriptional regulatory networks in the human genome. Post-transcriptional regulation of human genes by TE-derived sequences has ...