Now showing items 1-8 of 8

    • Characterization of Cre recombinase models for the study of adipose tissue 

      Jeffery, Elise; Berry, Ryan; Church, Christopher D; Yu, Songtao; Shook, Brett A; Horsley, Valerie; Rosen, Evan D; Rodeheffer, Matthew S (Landes Bioscience, 2014)
      The study of adipose tissue in vivo has been significantly advanced through the use of genetic mouse models. While the aP2-CreBI and aP2-CreSalk lines have been widely used to target adipose tissue, the specificity of these ...
    • Charting a dynamic DNA methylation landscape of the human genome 

      Ziller, Michael J.; Gu, Hongcang; Müller, Fabian; Donaghey, Julie; Tsai, Linus T.-Y.; Kohlbacher, Oliver; De Jager, Phil L.; Rosen, Evan D.; Bennett, David A.; Bernstein, Bradley E.; Gnirke, Andreas; Meissner, Alexander (2013)
      DNA methylation is a defining feature of mammalian cellular identity and essential for normal development1,2. Most cell types, except germ cells and pre-implantation embryos3–5, display relatively stable DNA methylation ...
    • Coordinated transcriptional regulation of bone homeostasis by Ebf1 and Zfp521 in both mesenchymal and hematopoietic lineages 

      Kiviranta, Riku; Yamana, Kei; Saito, Hiroaki; Ho, Daniel K.; Laine, Julius; Tarkkonen, Kati; Nieminen-Pihala, Vappu; Hesse, Eric; Correa, Diego; Määttä, Jorma; Tessarollo, Lino; Rosen, Evan D.; Horne, William C.; Jenkins, Nancy A.; Copeland, Neal G.; Warming, Soren; Baron, Roland (The Rockefeller University Press, 2013)
      Bone homeostasis is maintained by the coupled actions of hematopoietic bone-resorbing osteoclasts (OCs) and mesenchymal bone-forming osteoblasts (OBs). Here we identify early B cell factor 1 (Ebf1) and the transcriptional ...
    • Identification of nuclear hormone receptor pathways causing insulin resistance by transcriptional and epigenomic analysis 

      Kang, Sona; Tsai, Linus T.; Zhou, Yiming; Evertts, Adam; Xu, Su; Griffin, Michael J.; Issner, Robbyn; Whitton, Holly J.; Garcia, Benjamin A.; Epstein, Charles B.; Mikkelsen, Tarjei S.; Rosen, Evan D. (2014)
      Summary Insulin resistance is a sine qua non of Type 2 diabetes (T2D) and a frequent complication of multiple clinical conditions, including obesity, aging, and steroid use, among others. How such a panoply of insults can ...
    • IRF3 is a Critical Regulator of Adipose Glucose and Energy Homeostasis 

      Wang, Xun (2012-11-13)
      Obesity is associated with a state of chronic inflammation, which is believed to contribute to insulin resistance. We previously identified interferon regulatory factor 3 (IRF3) as an anti-adipogenic transcription factor ...
    • Lessons on Conditional Gene Targeting in Mouse Adipose Tissue 

      Lee, Kevin Y.; Russell, Steven J.; Ussar, Siegfried; Boucher, Jeremie; Vernochet, Cecile; Mori, Marcelo A.; Smyth, Graham; Rourk, Michael; Cederquist, Carly; Rosen, Evan D.; Kahn, Barbara B.; Kahn, C. Ronald (American Diabetes Association, 2013)
      Conditional gene targeting has been extensively used for in vivo analysis of gene function in adipocyte cell biology but often with debate over the tissue specificity and the efficacy of inactivation. To directly compare ...
    • New insights into adipocyte-specific leptin gene expression 

      Wrann, Christiane D.; Rosen, Evan D. (Landes Bioscience, 2012)
      The adipocyte-derived hormone leptin is a critical regulator of many physiological functions, ranging from satiety to immunity. Surprisingly, very little is known about the transcriptional pathways that regulate ...
    • Regulation of Early Adipose Commitment by Zfp521 

      Kang, Sona; Akerblad, Peter; Kiviranta, Riku; Gupta, Rana K.; Kajimura, Shingo; Griffin, Michael John; Min, Jie; Baron, Roland; Rosen, Evan David (Public Library of Science, 2012)
      While there has been significant progress in determining the transcriptional cascade involved in terminal adipocyte differentiation, less is known about early events leading to lineage commitment and cell fate choice. It ...