Now showing items 1-6 of 6

    • A Genome-Wide siRNA Screen in Mammalian Cells for Regulators of S6 Phosphorylation 

      Papageorgiou, Angela; Rapley, Joseph; Mesirov, Jill P.; Tamayo, Pablo; Avruch, Joseph (Public Library of Science, 2015)
      mTOR complex1, the major regulator of mRNA translation in all eukaryotic cells, is strongly activated in most cancers. We performed a genome-wide RNAi screen in a human cancer cell line, seeking genes that regulate S6 ...
    • The kinases Mst1 and Mst2 positively regulate phagocyte ROS induction and bactericidal activity 

      Geng, Jing; Sun, Xiufeng; Wang, Ping; Zhang, Shihao; Wang, Xiaozhen; Wu, Hongtan; Hong, Lixin; Xie, Changchuan; Li, Xun; Zhao, Hao; Liu, Qingxu; Jiang, Mingting; Chen, Qinghua; Zhang, Jinjia; Li, Yang; Song, Siyang; Wang, Hong-Rui; Zhou, Rongbin; Johnson, Randy L.; Chien, Kun-Yi; Lin, Sheng-Cai; Han, Jiahuai; Avruch, Joseph; Chen, Lanfen; Zhou, Dawang (2015)
      Summary Mitochondria need to be juxtaposted to phagosomes to synergistically produce ample reactive oxygen species (ROS) in phagocytes for pathogens killing. However, how phagosomes transmit signal to recruit mitochondria ...
    • The Mst1 and Mst2 kinases control activation of rho family GTPases and thymic egress of mature thymocytes 

      Mou, Fan; Praskova, Maria; Xia, Fan; Van Buren, Denille; Hock, Hanno Reinhard; Avruch, Joseph; Zhou, Dawang (The Rockefeller University Press, 2012)
      The Mst1 kinase is an important regulator of murine T cell adhesion, migration, proliferation, and apoptosis. In this study, we analyze mice lacking both Mst1 and Mst2 in hematopoietic cells. Compared with wild-type mice, ...
    • Mst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap1 Oncogene 

      Zhou, Dawang; Conrad, Claudius; Xia, Fan; Park, Ji-Sun; Payer, Bernhard; Yin, Yi; Lauwers, Gregory Y.; Thasler, Wolfgang; Lee, Jeannie T.; Avruch, Joseph; Bardeesy, Nabeel (Elsevier BV, 2009)
      Hippo-Lats-Yorkie signaling regulates tissue overgrowth and tumorigenesis in Drosophila. We show that the Mst1 and Mst2 protein kinases, the mammalian Hippo orthologs, are cleaved and constitutively activated in the mouse ...
    • Mst1/2 Signalling to Yap: Gatekeeper for Liver Size and Tumour Development 

      Avruch, Joseph; Zhou, D; Fitamant, Julien; Bardeesy, N (Nature Publishing Group, 2011)
      The mechanisms controlling mammalian organ size have long been a source of fascination for biologists. These controls are needed to both ensure the integrity of the body plan and to restrict inappropriate proliferation ...
    • Proof-of-Concept, Randomized, Controlled Clinical Trial of Bacillus-Calmette-Guerin for Treatment of Long-Term Type 1 Diabetes 

      Faustman, Denise Louise; Wang, Limei; Okubo, Yoshiaki; Burger, Douglas E.; Ban, Liqin; Man, Guotong; Zheng, Hui; Schoenfeld, David Alan; Pompei, Richard; Avruch, Joseph; Nathan, David Matthew (Public Library of Science, 2012)
      Background: No targeted immunotherapies reverse type 1 diabetes in humans. However, in a rodent model of type 1 diabetes, Bacillus Calmette-Guerin (BCG) reverses disease by restoring insulin secretion. Specifically, it ...