Browsing by Author "Liu, Yuting"
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Embryonic Development following Somatic Cell Nuclear Transfer Impeded by Persisting Histone Methylation
Matoba, Shogo; Liu, Yuting; Lu, Falong; Iwabuchi, Kumiko A; Inoue, Azusa; Zhang, Yi (Elsevier BV, 2014)Mammalian oocytes can reprogram somatic cells into a totipotent state enabling animal cloning through somatic cell nuclear transfer (SCNT). However, the majority of SCNT embryos fail to develop to term due to undefined ... -
Establishing Chromatin Regulatory Landscape during Mouse Preimplantation Development
Lu, Falong; Liu, Yuting; Inoue, Azusa; Suzuki, Tsukasa; Zhao, Keji; Zhang, Yi (Elsevier BV, 2016)How the chromatin regulatory landscape in the inner cell mass cells is established from differentially packaged sperm and egg genomes during preimplantation development is unknown. Here, we develop a low-input DNase I ... -
Histone Demethylase Expression Enhances Human Somatic Cell Nuclear Transfer Efficiency and Promotes Derivation of Pluripotent Stem Cells
Chung, Young Gie; Matoba, Shogo; Liu, Yuting; Eum, Jin Hee; Lu, Falong; Jiang, Wei; Lee, Jeoung Eun; Sepilian, Vicken; Cha, Kwang Yul; Lee, Dong Ryul; Zhang, Yi (Elsevier BV, 2015)The extremely low efficiency of human embryonic stem cell (hESC) derivation using somatic cell nuclear transfer (SCNT) limits its potential application. Blastocyst formation from human SCNT embryos occurs at a low rate and ... -
The lncRNA DEANR1 Facilitates Human Endoderm Differentiation by Activating FOXA2 Expression
Jiang, Wei; Liu, Yuting; Liu, Rui; Zhang, Kun; Zhang, Yi (Elsevier BV, 2015)Long non-coding RNAs (lncRNAs) regulate diverse biological processes, including cell lineage specification. Here, we report transcriptome profiling of human endoderm and pancreatic cell lineages using purified cell ... -
Role of Tet proteins in enhancer activity and telomere elongation
Lu, Falong; Liu, Yuting; Jiang, Lan; Yamaguchi, Shinpei; Zhang, Yi (Cold Spring Harbor Laboratory Press, 2014)DNA methylation at the C-5 position of cytosine (5mC) is one of the best-studied epigenetic modifications and plays important roles in diverse biological processes. Iterative oxidation of 5mC by the ten-eleven translocation ... -
Tet3 and DNA Replication Mediate Demethylation of Both the Maternal and Paternal Genomes in Mouse Zygotes
Shen, Li; Inoue, Azusa; He, Jin; Liu, Yuting; Lu, Falong; Zhang, Yi (Elsevier BV, 2014)With the exception of imprinted genes and certain repeats, DNA methylation is globally erased during preimplantation development. Recent studies have suggested that Tet3-mediated oxidation of 5-methylcytosine (5mC) and DNA ...