Now showing items 1-4 of 4

    • Structural Organization and Interactions of Transmembrane Domains in Tetraspanin Proteins 

      Kovalenko, Oleg V; Metcalf, Douglas G; DeGrado, William F; Hemler, Martin Edward (BioMed Central, 2005)
      Background: Proteins of the tetraspanin family contain four transmembrane domains (TM1-4) linked by two extracellular loops and a short intracellular loop, and have short intracellular N- and C-termini. While structure and ...
    • Tetraspanin CD151 plays a key role in skin squamous cell carcinoma 

      Li, Qinglin; Yang, Xiuwei H.; Xu, Fenghui; Sharma, Chandan; Wang, Hong-Xing; Knoblich, Konstantin; Rabinovitz, Isaac; Granter, Scott R.; Hemler, Martin E. (2012)
      Here we provide the first evidence that tetraspanin CD151 can support de novo carcinogenesis. During two-stage mouse skin chemical carcinogenesis, CD151 reduces tumor lag time and increases incidence, multiplicity, size, ...
    • Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks 

      Malhotra, Deepali; Fletcher, Anne; Astarita, Jillian Leigh; Lukacs-Kornek, Veronika; Tayalia, Prakriti; Gonzalez, Santiago F.; Elpek, Kutlu G.; Chang, Sook Kyung; Knoblich, Konstantin; Hemler, Martin Edward; Brenner, Michael Barry; Carroll, Michael C.; Mooney, David J.; Turley, Shannon J. (Nature Publishing Group, 2012)
      Lymph node stromal cells (LNSCs) closely regulate immunity and self-tolerance, yet key aspects of their biology remain poorly illuminated. Comparative transcriptomic analyses of murine LNSC subsets revealed expression of ...
    • β1 Integrins Show Specific Association with CD98 Protein in Low Density Membranes 

      Kolesnikova, Tatiana V; Mannion, Brian A; Berditchevski, Fedor; Hemler, Martin Edward (BioMed Central, 2001)
      Background: The CD98 (4F2, FRP-1) is a widely expressed cell surface protein heterodimer composed of a glycosylated heavy chain and a non-glycosylated light chain. Originally described as a T cell activation antigen, it ...