Browsing by Author "Xu, Xiang"

Now showing items 1-5 of 5

    • Biased Multicomponent Reactions to Develop Novel Bromodomain Inhibitors 

      McKeown, Michael R; Shaw, Daniel L; Fu, Harry; Liu, Shuai; Xu, Xiang; Marineau, Jason J; Huang, Yibo; Zhang, Xiaofeng; Buckley, Dennis L; Kadam, Asha; Zhang, Zijuan; Blacklow, Stephen C; Qi, Jun; Zhang, Wei; Bradner, James E (American Chemical Society, 2014)
      BET bromodomain inhibition has contributed new insights into gene regulation and emerged as a promising therapeutic strategy in cancer. Structural analogy of early methyl-triazolo BET inhibitors has prompted a need for ...

    • Effect of Environmental Tobacco Smoke on Levels of Urinary Hormone Markers 

      Wang, Xiaobin; Wang, Lihua; Yang, Fan; Tang, Genfu; Xing, Houxun; Lasley, Bill; Overstreet, James W.; Stanford, Joseph B.; Chen, ChangFeng; Ryan, Louise Marie; Xu, Xiang (National Institute of Environmental Health Sciences, 2005)
      Our recent study showed a dose–response relationship between environmental tobacco smoke (ETS) and the risk of early pregnancy loss. Smoking is known to affect female reproductive hormones. We explored whether ETS affects ...

    • Identification of a New Epitope in uPAR as a Target for the Cancer Therapeutic Monoclonal Antibody ATN-658, a Structural Homolog of the uPAR Binding Integrin CD11b (αM) 

      Xu, Xiang; Cai, Yuan; Wei, Ying; Donate, Fernando; Juarez, Jose; Parry, Graham; Chen, Liqing; Meehan, Edward J.; Ahn, Richard W.; Ugolkov, Andrey; Dubrovskyi, Oleksii; O'Halloran, Thomas V.; Huang, Mingdong; Mazar, Andrew P. (Public Library of Science, 2014)
      The urokinase plasminogen activator receptor (uPAR) plays a role in tumor progression and has been proposed as a target for the treatment of cancer. We recently described the development of a novel humanized monoclonal ...

    • A multi-modular tensegrity model of an actin stress fiber 

      Luo, Yaozhi; Xu, Xiang; Lele, Tanmay; Kumar, Sanjay; Ingber, Donald Elliot (Elsevier, 2008)
      Stress fibers are contractile bundles in the cytoskeleton that stabilize cell structure by exerting traction forces on the extracellular matrix. Individual stress fibers are molecular bundles composed of parallel actin ...

    • Structure-Guided DOT1L Probe Optimization by Label-Free Ligand Displacement 

      Yi, Joanna S.; Federation, Alexander J.; Qi, Jun; Dhe-Paganon, Sirano; Hadler, Michael; Xu, Xiang; St. Pierre, Roodolph; Varca, Anthony C.; Wu, Lei; Marineau, Jason J.; Smith, William B.; Souza, Amanda; Chory, Emma J.; Armstrong, Scott A.; Bradner, James E. (American Chemical Society, 2014)
      The DOT1L lysine methyltransferase has emerged as a validated therapeutic target in MLL-rearranged (MLLr) acute leukemias. Although S-adenosylmethionine competitive inhibitors have demonstrated pharmacological proof-of-principle ...