Now showing items 1-8 of 8

    • Adult Cardiac Progenitor Cell Aggregates Exhibit Survival Benefit Both In Vitro and In Vivo 

      Bauer, Michael; Kang, Lifeng; Qiu, Yiling; Wu, Jinhui; Peng, Michelle; Chen, Howard H.; Camci-Unal, Gulden; Bayomy, Ahmad F.; Sosnovik, David E.; Khademhosseini, Ali; Liao, Ronglih (Public Library of Science, 2012)
      Background: A major hurdle in the use of exogenous stems cells for therapeutic regeneration of injured myocardium remains the poor survival of implanted cells. To date, the delivery of stem cells into myocardium has largely ...
    • [Ca2+]i in Human Heart Failure: A Review and Discussion of Current Areas of Controversy. 

      Liao, Ronglih; Helm, P. A.; Hajjar, R. J.; Saha, C.; Gwathmey, Judith Karen (Yale Journal of Biology and Medicine, 1994)
      Multiple abnormalities have been reported in the setting of human heart failure. It is unclear whether detected changes reflect adaptive alterations in myocardium subjected to increased and sustained hemodynamic overload ...
    • Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats 

      Fisch, Sudeshna; Liao, Ronglih; Hsiao, Li-Li; Lu, Tzongshi (MyJove Corporation, 2016)
      The kidney normally functions to maintain hemodynamic homeostasis and is a major site of damage caused by drug toxicity. Drug-induced nephrotoxicity is estimated to contribute to 19- 25% of all clinical cases of acute ...
    • Identifying Early Changes in Myocardial Microstructure in Hypertensive Heart Disease 

      Hiremath, Pranoti; Bauer, Michael; Aguirre, Aaron D.; Cheng, Hui-Wen; Unno, Kazumasa; Patel, Ravi B.; Harvey, Bethany W.; Chang, Wei-Ting; Groarke, John D.; Liao, Ronglih; Cheng, Susan (Public Library of Science, 2014)
      The transition from healthy myocardium to hypertensive heart disease is characterized by a series of poorly understood changes in myocardial tissue microstructure. Incremental alterations in the orientation and integrity ...
    • Lysosomal dysfunction and impaired autophagy underlie the pathogenesis of amyloidogenic light chain-mediated cardiotoxicity 

      Guan, Jian; Mishra, Shikha; Qiu, Yiling; Shi, Jianru; Trudeau, Kyle; Las, Guy; Liesa, Marc; Shirihai, Orian S; Connors, Lawreen H; Seldin, David C; Falk, Rodney H; MacRae, Calum A; Liao, Ronglih (BlackWell Publishing Ltd, 2014)
      AL amyloidosis is the consequence of clonal production of amyloidogenic immunoglobulin light chain (LC) proteins, often resulting in a rapidly progressive and fatal amyloid cardiomyopathy. Recent work has found that ...
    • Microfluidics-Assisted Fabrication of Gelatin-Silica Core–Shell Microgels for Injectable Tissue Constructs 

      Cha, Chaenyung; Oh, Jonghyun; Kim, Keekyoung; Qiu, Yiling; Joh, Maria; Shin, Su Ryon; Wang, Xin; Camci-Unal, Gulden; Wan, Kai-tak; Liao, Ronglih; Khademhosseini, Ali (American Chemical Society, 2013)
      Microfabrication technology provides a highly versatile platform for engineering hydrogels used in biomedical applications with high-resolution control and injectability. Herein, we present a strategy of microfluidics-assisted ...
    • Phenotypic Spectrum Caused by Transgenic Overexpression of Activated Akt in the Heart 

      Matsui, Takashi; Li, Ling; Wu, Justina C.; Cook, Stuart; Nagoshi, Tomohisa; Picard, Michael Howard; Liao, Ronglih; Rosenzweig, Anthony (American Society for Biochemistry & Molecular Biology (ASBMB), 2002)
      The serine-threonine kinase, Akt, inhibits cardiomyocyte apoptosis acutely both in vitro and in vivo. However, the effects of chronic Akt activation in the heart are unknown. To address this issue, we generated transgenic ...
    • Regional Cardiac Dysfunction and Dyssynchrony in a Murine Model of Afterload Stress 

      Bauer, Michael; Cheng, Susan; Unno, Kazumasa; Lin, Fen-Chiung; Liao, Ronglih (Public Library of Science, 2013)
      Small animal models of afterload stress have contributed much to our present understanding of the progression from hypertension to heart failure. High-sensitivity methods for phenotyping cardiac function in vivo, particular ...