Browsing by Author "Leng, Yumei"

Now showing items 1-2 of 2

    • Global Identification of Modular Cullin-RING Ligase Substrates 

      Emanuele, Michael J.; Xu, Qikai; Thoma, Claudio R.; Izhar, Lior; Leng, Yumei; Guo, Ailan; Chen, Yi-Ning; Rush, John; Hsu, Paul Wei-Che; Yen, Hsueh-Chi Sherry; Elledge, Stephen; Elia, Andrew (Elsevier BV, 2011-10)
      Cullin-RING ligases (CRLs) represent the largest E3 ubiquitin ligase family in eukaryotes, and the identification of their substrates is critical to understanding regulation of the proteome. Using genetic and pharmacologic ...

    • A Systematic Analysis of Factors Localized to Damaged Chromatin Reveals PARP-Dependent Recruitment of Transcription Factors 

      Izhar, Lior; Adamson, Britt; Ciccia, Alberto; Lewis, Jedd; Pontano-Vaites, Laura; Leng, Yumei; Westbrook, Thomas F.; Elledge, Stephen; Liang, Anthony; Harper, Jeffrey (Elsevier BV, 2015-06)
      Localization to sites of DNA damage is a hallmark of DNA damage response (DDR) proteins. To identify DDR factors, we screened epitope-tagged proteins for localization to sites of chromatin damaged by UV laser microirradiation ...