Browsing by Author "Mantzoros, Christos"
Now showing items 1-18 of 18
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Circulating Irisin Levels Are Not Affected by Coffee Intake: A Randomized Controlled Trial
Peter, Patricia R.; Park, Kyung Hee; Huh, Joo Young; Wedick, Nicole M.; Mantzoros, Christos S. (Public Library of Science, 2014)Irisin, secreted by skeletal muscle and possibly fat, is hypothesized to play an important role in modulating energy expenditure, obesity and metabolism. Coffee consumption also increases energy expenditure and leads to ... -
The Development of INT131 as a Selective PPARγ Modulator: Approach to a Safer Insulin Sensitizer
Higgins, Linda S.; Mantzoros, Christos S. (Hindawi Publishing Corporation, 2008)INT131 (formerly T0903131, T131, AMG131) is a potent non-thiazolidinedione (TZD) selective peroxisome proliferator-activated receptor γ modulator (SPPARM) currently in Phase 2 clinical trials for treatment of type-2 ... -
Differential associations of leptin with adiposity across early childhood
Boeke, Caroline E.; Mantzoros, Christos S.; Hughes, Michael D.; Rifas-Shiman, Sheryl L.; Villamor, Eduardo; Zera, Chloe A.; Gillman, Matthew W. (2013)Objective: We examined associations of perinatal and 3-year leptin with weight gain and adiposity through 7 years. Design and Methods In Project Viva, we assessed plasma leptin from mothers at 26–28 weeks’ gestation (n=893), ... -
Duration of Lactation and Maternal Adipokines at 3 Years Postpartum
Stuebe, Alison M.; Mantzoros, Christos; Kleinman, Ken Paul; Gillman, Matthew William; Rifas-Shiman, Sheryl Lynn; Gunderson, Erica P.; Rich-Edwards, Janet Wilson (American Diabetes Association, 2011)Objective: Lactation has been associated with reduced maternal risk of type 2 diabetes, the metabolic syndrome, and cardiovascular disease. We examined the relationship between breastfeeding duration and maternal adipokines ... -
The Effects of Caffeinated and Decaffeinated Coffee on Sex Hormone-Binding Globulin and Endogenous Sex Hormone Levels: A Randomized Controlled Trial
Wedick, Nicole Marie; Mantzoros, Christos; Ding, Eric L.; Brennan, Aoife M; Rosner, Bernard Alfred; Rimm, Eric B.; Hu, Frank B.; van Dam, Rob M. (BioMed Central, 2012)Background: Findings from observational studies suggest that sex hormone-binding globulin (SHBG) and endogenous sex hormones may be mediators of the putative relation between coffee consumption and lower risk of type 2 ... -
Effects of Lipid-Lowering Drugs on Irisin in Human Subjects In Vivo and in Human Skeletal Muscle Cells Ex Vivo
Gouni-Berthold, Ioanna; Berthold, Heiner K.; Huh, Joo Young; Berman, Reena; Spenrath, Nadine; Krone, Wilhelm; Mantzoros, Christos S. (Public Library of Science, 2013)Context and Objective The myokine irisin has been proposed to regulate energy homeostasis. Little is known about its association with metabolic parameters and especially with parameters influencing pathways of lipid ... -
Efficacy of Metreleptin in Obese Patients With Type 2 Diabetes: Cellular and Molecular Pathways Underlying Leptin Tolerance
Matarese, Giuseppe; Brennan, Aoife M.; Chamberland, John P.; Fiorenza, Christina G.; Mylvaganam, Geetha H.; Abanni, Luisa; Carbone, Fortunata; De Paoli, Alex M.; Moon, Hyun-Seuk; Liu, Xiaowen; Williams, Catherine J.; Schneider, Benjamin Edward; Mantzoros, Christos (American Diabetes Association, 2011)Objective: Metreleptin has been efficacious in improving metabolic control in patients with lipodystrophy, but its efficacy has not been tested in obese patients with type 2 diabetes. Research Design and Methods: We studied ... -
Lack of mature lymphocytes results in obese but metabolically healthy mice when fed a high-fat diet
Liu, Xiaowen; Huh, Joo Young; Gong, Huizhi; Chamberland, John; Hamnvik, Ole-Petter Riksfjord; Mantzoros, Christos (Springer Science and Business Media LLC, 2015-05-21)Background/Objectives: Obesity is characterized by chronic inflammation and immune dysregulation, as well as insulin resistance, but the link between obesity and adaptive immunity remains to be fully studied. Methods: To ... -
Leptin and Amylin Act in an Additive Manner to Activate Overlapping Signaling Pathways in Peripheral Tissues
Moon, Hyun-Seuk; Chamberland, John P.; Diakopoulos, Kalliope N.; Fiorenza, Christina G.; Ziemke, Florencia; Schneider, Benjamin Edward; Mantzoros, Christos (American Diabetes Association, 2011)OBJECTIVE: Amylin interacts with leptin to alter metabolism. We evaluated, for the first time, amylin- and/or leptin-activated signaling pathways in human peripheral tissues (hPTs). RESEARCH DESIGN AND METHODS: Leptin and ... -
Leptin and Its Emerging Role in Children and Adolescents
Kelesidis, Iosif; Mantzoros, Christos S. (The Japanese Society for Pediatric Endocrinology, 2006)Leptin is an adipocyte-secreted hormone which plays a key role in energy homeostasis. Recent “proof of concept” studies involving leptin administration to humans support its critical role in regulating energy homeostasis, ... -
Leptin as a Modulator of Neuroendocrine Function in Humans
Khan, Sami M.; Hamnvik, Ole-Petter Riksfjord; Brinkoetter, Mary; Mantzoros, Christos (Yonsei University College of Medicine, 2012)Leptin, a peptide hormone secreted by adipocytes in proportion of the amount of energy stored in fat, plays a central role in regulating human energy homeostasis. In addition, leptin plays a significant permissive role in ... -
Leptin in Relation to the Lipodystrophy-Associated Metabolic Syndrome
Mantzoros, Christos (Korean Diabetes Association, 2012)Leptin, an adipocyte-secreted hormone, regulates energy homeostasis as well as reproductive, neuroendocrine, immune and metabolic functions. Subjects with decreased amounts of fat in their adipose tissue, i.e., lipoatrophy, ... -
Novel Molecules Regulating Energy Homeostasis: Physiology and Regulation by Macronutrient Intake and Weight Loss
Gavrieli, Anna; Mantzoros, Christos S. (Korean Endocrine Society, 2016)Excess energy intake, without a compensatory increase of energy expenditure, leads to obesity. Several molecules are involved in energy homeostasis regulation and new ones are being discovered constantly. Appetite regulating ... -
Omentin-1 levels are reduced by pharmacologic doses of leptin, but remain unaffected by energy deprivation and display no day-night variation
Hamnvik, Ole-Petter Riksfjord; Thakkar, Bindiya; Chamberland, John; Aronis, Konstantinos; Schneider, Benjamin; Mantzoros, Christos S. (2014)Objective: To study the day-night variation of omentin-1 levels and assess whether leptin, and/or short-and long-term energy deprivation alter circulating omentin-1 levels via cytokines. Design and Methods Omentin-1 levels ... -
Phobic Anxiety is Associated with Higher Serum Concentrations of Adipokines and Cytokines in Women with Diabetes
Brennan, Aoife M.; Fargnoli, Jessica L.; Williams, Catherine J.; Li, Tricia; Willett, Walter C.; Kawachi, Ichiro; Qi, Lu; Hu, Frank B.; Mantzoros, Christos S. (American Diabetes Association, 2009)OBJECTIVE: Phobic anxiety has been associated with increased risk of cardiovascular disease (CVD), but the underlying mechanisms are poorly understood. We aimed to determine whether associations of phobic anxiety with ... -
Regulation of Mouse Hepatic Genes in Response to Diet Induced Obesity, Insulin Resistance and Fasting Induced Weight Reduction
Raab, R Michael; Bullen, John; Kelleher, Joanne; Mantzoros, Christos S.; Stephanopoulos, Gregory (BioMed Central, 2005)Background: Obesity is associated with insulin resistance that can often be improved by caloric restriction and weight reduction. Although many physiological changes accompanying insulin resistance and its treatment have ... -
Sex Disparities in the Treatment and Control of Cardiovascular Risk Factors in Type 2 Diabetes
Gouni-Berthold, Ioanna; Berthold, Heiner K.; Böhm, Michael; Krone, Wilhelm; Mantzoros, Christos S. (American Diabetes Association, 2008)OBJECTIVE—To assess whether sex differences exist in the effective control and medication treatment intensity of cardiovascular disease (CVD) risk factors. RESEARCH DESIGN AND METHODS—We performed a cross-sectional analysis ... -
Total and High-Molecular-Weight Adiponectin and Risk of Incident Diabetes in Older People
Kizer, Jorge R.; Arnold, Alice M.; Benkeser, David; Ix, Joachim H.; Djousse, Luc; Zieman, Susan J.; Barzilay, Joshua I.; Tracy, Russell P.; Mantzoros, Christos S.; Siscovick, David S.; Mukamal, Kenneth J. (American Diabetes Association, 2012)OBJECTIVE To delineate the associations of total adiponectin, high-molecular-weight (HMW) adiponectin, and the HMW-to-total adiponectin ratio with diabetes in older adults. RESEARCH DESIGN AND METHODS Total and HMW adiponectin ...