Now showing items 1-6 of 6

    • Diverse intracellular pathogens activate Type III Interferon expression from peroxisomes 

      Odendall, Charlotte; Dixit, Evelyn; Stavru, Fabrizia; Bierne, Helene; Franz, Kate M.; Fiegen, Ann; Boulant, Steeve; Gehrke, Lee; Cossart, Pascale; Kagan, Jonathan C. (2014)
      Type I Interferon (IFN) responses are considered the primary means by which viral infections are controlled in mammals. Despite this view, several pathogens activate antiviral responses in the absence of Type I IFNs. The ...
    • Evasion of MDA5-Mediated Innate Immunity by Paramyxoviruses 

      Davis, Meredith Elizabeth (2015-05-04)
      The innate immune sensor MDA5, a RIG-I-like receptor (RLR), is critical for the detection of viral nucleic acid, eliciting an antiviral immune response. Aberrant immune activation can be detrimental to the host; therefore, ...
    • Field-deployable viral diagnostics using CRISPR-Cas13 

      Yozwiak, Nathan; Michael, Scott; Isern, Sharon; Nogueira, Mauricio; Barnes, Kayla; Freije, Catherine; Sabeti, Pardis; Abudayyeh, Omar; Gehrke, Lee; Myhrvold, Cameron; Bosch, Irene; Durbin, Ann; Gootenberg, Jonathan; Kellner, Max; Zhang, Feng; Metsky, Hayden; Tan, Amanda; Parham, Leda; Garcia, Kimberly; Lorenzana, Ivette; Chak, Bridget; Mondini, Adriano; MacInnis, Bronwyn; Paul, Lauren
    • Interplay of Dengue Virus and the Human Immune Response 

      Chan, Ying Kai (2015-05-07)
      RIG-I is a key cytosolic sensor of many RNA viruses, including dengue virus (DV), the most significant arboviral pathogen. Upon viral RNA binding, RIG-I signals via the adaptor protein MAVS, located at mitochondria, to ...
    • RNAs Containing Modified Nucleotides Fail To Trigger RIG-I Conformational Changes for Innate Immune Signaling 

      Durbin, Ann Fiegen; Wang, Chen; Marcotrigiano, Joseph; Gehrke, Lee (American Society for Microbiology, 2016)
      ABSTRACT Invading pathogen nucleic acids are recognized and bound by cytoplasmic (retinoic acid-inducible gene I [RIG-I]-like) and membrane-bound (Toll-like) pattern recognition receptors to activate innate immune signaling. ...
    • Zika virus evolution and spread in the Americas 

      Metsky, Hayden C; Matranga, Christian B; Wohl, Shirlee; Schaffner, Stephen; Freije, Catherine Amanda; Winnicki, Sarah M.; West, Kendra Leigh; Qu, James; Baniecki, Mary; Gladden-Young, Adrianne; Lin, Aaron Eric; Tomkins-Tinch, Christopher Holiday; Ye, Simon H; Park, Daniel Sangsoon; Luo, Cynthia; Barnes, Kayla G.; Shah, Rickey; Chak, Bridget; Barbosa-Lima, Giselle; Delatorre, Edson; Vieira, Yasmine R; Paul, Lauren M; Tan, Amanda L; Barcellona, Carolyn M; Porcelli, Mario C; Vasquez, Chalmers; Cannons, Andrew C; Cone, Marshall R; Hogan, Kelly N; Kopp, Edgar W; Anzinger, Joshua J; Garcia, Kimberly F; Parham, Leda A; Gelvez Ramirez, Rosa Margarita; Miranda Montoya, Maria Consuelo; Rojas, Diana P; Brown, Catherine M; Hennigan, Scott; Sabina, Brandon; Scotland, Sarah; Gangavarapu, Karthik; Grubaugh, Nathan D; Oliveira, Glenn; Robles-Sikisaka, Refugio; Rambaut, Andrew; Gehrke, Lee; Smole, Sandra; Halloran, M Elizabeth; Villar Centeno, Luis Angel; Mattar, Salim; Lorenzana, Ivette; Cerbino-Neto, Jose; Valim, Clarissa; Degrave, Wim; Bozza, Patricia T; Gnirke, Andreas; Andersen, Kristian G; Isern, Sharon; Michael, Scott; Bozza, Fernando A; Souza, Thiago ML; Bosch, Irene; Yozwiak, Nathan L; MacInnis, Bronwyn L; Sabeti, Pardis Christine (SpringerNature, 2017)
      Despite great attention given to the recent Zika virus (ZIKV) epidemic in the Americas, much remains unknown about its epidemiology and evolution, in part due to a lack of genomic data. We applied multiple sequencing ...