Now showing items 1-11 of 11

    • Antiretroviral Regimens in Pregnancy and Breast-Feeding in Botswana 

      Shapiro, R.L.; Hughes, M.D.; Ogwu, Anthony; Kitch, Doug William; Lockman, Shahin; Moffat, C.; Makhema, Joseph Moeketsi; Moyo, S; Thior, Ibou; McIntosh, Kenneth; van Widenfelt, E.; Leidner, Jean A.; Powis, Kathleen Marie; Asmelash, A.; Tumbare, E.; Zwerski, S.; Sharma, Upasna; Handelsman, E.; Mburu, K.; Jayeoba, O.; Moko, E.; Souda, Shashidhar Vaman; Lubega, E.; Akhtar, M.; Wester, C William; Tuomola, R.; Snowden, W.; Martinez-Tristani, M.; Mazhani, L.; Essex, Myron Elmer (New England Journal of Medicine (NEJM/MMS), 2010)
      BACKGROUND: The most effective highly active antiretroviral therapy (HAART) to prevent mother-to-child transmission of human immunodeficiency virus type 1 (HIV-1) in pregnancy and its efficacy during breast-feeding are ...
    • HIV-1 Subtype C-Infected Individuals Maintaining High Viral Load as Potential Targets for the “Test-and-Treat” Approach to Reduce HIV Transmission 

      Baum, Marianna; Thior, Ibou; Asmelash, Aida; Campa, Adriana; van Widenfelt, Erik; Mine, Madisa; Moffat, Claire; Mmalane, Mompati; Gilbert, Peter; Novitsky, Vladimir A.; Wang, Rui; Bussmann, Hermann; Lockman, Shahin; Shapiro, Roger L.; Wester, Carolyn Negley; Wester, C William; Ogwu, Anthony; Musonda, Rosemary Mubanga; Moyo, Sikhulile; Makhema, Joseph Moeketsi; Marlink, Richard George; Seage, George R.; De Gruttola, Victor Gerard; Essex, Myron Elmer (Public Library of Science, 2010)
      The first aim of the study is to assess the distribution of HIV-1 RNA levels in subtype C infection. Among 4,348 drug-naïve HIV-positive individuals participating in clinical studies in Botswana, the median baseline plasma ...
    • Immune Activation Markers in Peripartum Women in Botswana: Association with Feeding Strategy and Maternal Morbidity 

      Russell, Elizabeth S.; Mohammed, Terence; Smeaton, Laura Marie; Jorowe, Baitshepi; MacLeod, Iain James; Hoffman, Risa M.; Currier, Judith S.; Moyo, Sikhulile; Essex, Max; Lockman, Shahin (Public Library of Science (PLoS), 2014)
      Hormone levels shift the immune state in HIV-uninfected pregnant and breastfeeding women away from Th1 responses and toward regulation to permit fetal tolerance. Limited data exist on inflammation during pregnancy or ...
    • Immunohaematological reference values for HIV-negative healthy adults in Botswana 

      Mine, Madisa; Moyo, Sikhulile; Stevens, Penny; Michael, Kurt; Novitsky, Vladimir A.; Makhaola, Kgomotso; Asmelash, Aida; Molefhabangwe, S’khatele; Woldegabriel, Elias; Mothowaeng, Gaseboloke; Maruta, Talkmore; Kamhukamwe, Charity; Mangwendeza, Phibeon M.; Holmes-Pretorius, Molly; Mtoni, Isaac; Motswaledi, Modisa; Musonda, Rosemary Mubanga; Ndwapi, Ndwapi; Makhema, Joseph Moeketsi; Marlink, Richard G.; Seipone, Khumo; Gaolathe, Tendani; Essex, Myron Elmer (AOSIS, 2011)
      BACKGROUND: Clinical laboratories in Botswana have relied entirely on the reference intervals for normal immunohaematological values provided by manufacturers' kits and textbooks. OBJECTIVES: The aim of this study was to ...
    • Length of secondary schooling and risk of HIV infection in Botswana: evidence from a natural experiment 

      de Neve, Jan-Walter J.l.m.; Fink, Gunther; Subramanian, S.V. Venkata; Moyo, Sikhulile; Bor, Jacob (Elsevier BV, 2015)
      Background: An estimated 2·1 million individuals are newly infected with HIV every year. Cross-sectional and longitudinal studies have reported conflicting evidence for the association between education and HIV risk, and ...
    • Long-Range HIV Genotyping Using Viral RNA and Proviral DNA for Analysis of HIV Drug Resistance and HIV Clustering 

      Novitsky, Vladimir A.; Zahralban-Steele, Melissa; McLane, Mary Frances; Moyo, Sikhulile; van Widenfelt, Erik; Gaseitsiwe, Simani; Makhema, Joseph Moeketsi; Essex, Myron Elmer (American Society for Microbiology, 2015)
      The goal of the study was to improve the methodology of HIV genotyping for analysis of HIV drug resistance and HIV clustering. Using the protocol of Gall et al. (A. Gall, B. Ferns, C. Morris, S. Watson, M. Cotten, M. ...
    • P20-12. Heterogeneity of Gag Mutational Pathways in Primary HIV-1 Subtype C Infection 

      Lagakos, S; Kebaabetswe, L; Rossenkhan, R; Woldegabriel, E; van Widenfelt, E; Novitsky, Vladimir A.; Wang, Richard Yun; Margolin, Lauren; Baca, Jeannie; Moyo, Sikhulile; Makhema, Joseph Moeketsi; Essex, Myron Elmer (BioMed Central, 2009)
      Poster presentation
    • Phylodynamic analysis of HIV sub-epidemics in Mochudi, Botswana 

      Novitsky, Vladimir A.; Kühnert, Denise; Moyo, Sikhulile; Widenfelt, Erik; Okui, Lillian; Essex, Myron Elmer (Elsevier BV, 2015)
      Southern Africa continues to be the epicenter of the HIV/AIDS epidemic. This HIV-1 subtype C epidemic has a predominantly heterosexual mode of virus transmission and high (>15%) HIV prevalence among adults. The epidemiological ...
    • Secondary education and HIV infection in Botswana 

      de Neve, Jan-Walter J.l.m.; Fink, Gunther; Subramanian, S.V. Venkata; Moyo, Sikhulile; Bor, Jacob (Elsevier BV, 2016)
      In a reanalysis of our results,1 Michelle Remme and colleagues (October, 2015)2 found that “secondary schooling might [even] be as good an HIV investment as male circumcision”, not to mention more expensive biomedical ...
    • Timing Constraints of In Vivo Gag Mutations during Primary HIV-1 Subtype C Infection 

      Kebaabetswe, Lemme; Rossenkhan, Raabya; Bonney, Caitlin; Herzig, Michaela; Nkwe, David; Woldegabriel, Elias; van Widenfelt, Erik; Lagakos, Stephen; Zhang, Linqi; Novitsky, Vladimir A.; Wang, Rui; Margolin, Lauren; Baca, Jeannie; Moyo, Sikhulile; Musonda, Rosemary Mubanga; Makhema, Joseph Moeketsi; Essex, Myron Elmer (Public Library of Science, 2009)
      Background: Aiming to answer the broad question “When does mutation occur?” this study examined the time of appearance, dominance, and completeness of in vivo Gag mutations in primary HIV-1 subtype C infection. Methods: A ...
    • Validation of A Point-of-Care Lactate Device For Screening At-Risk Adults Receiving Combination Antiretroviral Therapy In Botswana 

      Moyo, Sikhulile; Bussmann, Hermann; Mangwendeza, Phibeon; Essex, Myron Elmer (OMICS Publishing Group, 2011)
      BACKGROUND: Nucleoside reverse-transcriptase inhibitors (NRTIs) are a major component of combination antiretroviral therapy (cART) worldwide but they have been associated with mitochondrial toxicities, with one of the most ...