Now showing items 1-5 of 5

    • Broad targeting of angiogenesis for cancer prevention and therapy 

      Wang, Zongwei; Dabrosin, Charlotta; Yin, Xin; Fuster, Mark M.; Arreola, Alexandra; Rathmell, W. Kimryn; Generali, Daniele; Nagaraju, Ganji P.; El-Rayes, Bassel; Ribatti, Domenico; Chen, Yi Charlie; Honoki, Kanya; Fujii, Hiromasa; Georgakilas, Alexandros G.; Nowsheen, Somaira; Amedei, Amedeo; Niccolai, Elena; Amin, Amr; Ashraf, S. Salman; Helferich, Bill; Yang, Xujuan; Guha, Gunjan; Bhakta, Dipita; Ciriolo, Maria Rosa; Aquilano, Katia; Chen, Sophie; Halicka, Dorota; Mohammed, Sulma I.; Azmi, Asfar S.; Bilsland, Alan; Keith, W. Nicol; Jensen, Lasse D. (Academic Press, 2015)
      Deregulation of angiogenesis – the growth of new blood vessels from an existing vasculature – is a main driving force in many severe human diseases including cancer. As such, tumor angiogenesis is important for delivering ...
    • Inhibition of TNF-α Improves the Bladder Dysfunction That Is Associated With Type 2 Diabetes 

      Wang, Zongwei; Cheng, Zhiyong; Cristofaro, Vivian; Li, Jijun; Xiao, Xingyuan; Gomez, Pablo; Ge, Rongbin; Gong, Edward; Strle, Klemen; Sullivan, Maryrose P.; Adam, Rosalyn M.; White, Morris F.; Olumi, Aria F. (American Diabetes Association, 2012)
      Diabetic bladder dysfunction (DBD) is common and affects 80% of diabetic patients. However, the molecular mechanisms underlying DBD remain elusive because of a lack of appropriate animal models. We demonstrate DBD in a ...
    • Metformin represses cancer cells via alternate pathways in N-cadherin expressing vs. N-cadherin deficient cells 

      Ge, Rongbin; Wang, Zongwei; Wu, Shulin; Zhuo, Yangjia; Otsetov, Aleksandar G.; Cai, Chao; Zhong, Weide; Wu, Chin-Lee; Olumi, Aria F. (Impact Journals LLC, 2015)
      Metformin has emerged as a potential anticancer agent. Here, we demonstrate that metformin plays an anti-tumor role via repressing N-cadherin, independent of AMPK, in wild-type N-cadherin cancer cells. Ectopic-expression ...
    • Quantization and diagnosis of Shanghuo (Heatiness) in Chinese medicine using a diagnostic scoring scheme and salivary biochemical parameters 

      Liu, Sijun; Huang, Zhaosheng; Wu, Qingguang; Huang, Zhangjie; Wu, Lirong; Yan, Wenli; Chang, David Lungpao; Yang, Zheng; Wang, Zongwei (BioMed Central, 2014)
      Background: This study aims to establish a diagnostic scoring scheme for Shanghuo (Heatiness) and to evaluate whether Shanghuo is associated with biochemical parameters of salivary lysozyme (LYZ), salivary secreted ...
    • SATB1 Overexpression Regulates the Development and Progression in Bladder Cancer through EMT 

      Wan, Feng; Cheng, Chao; Wang, Zongwei; Xiao, Xingyuan; Zeng, Hanqing; Xing, Shian; Chen, Xuepan; Wang, Jin; Li, Sen; Zhang, Youpeng; Xiang, Wei; Zhu, Zhineng; Johnson, Cameron; Zhu, Zhaohui (Public Library of Science, 2015)
      The global gene regulator Special AT-rich sequence-binding protein-1 (SATB1) has been reported to induce EMT-like changes and be associated with poor clinical outcome in several cancers. This study aims to evaluate whether ...