Now showing items 1-8 of 8

    • Combinatorial Pathway Modulation Toward Ex Vivo Maintenance and Propagation of Hematopoietic Stem Cells 

      Ebina, Wataru (2016-05-18)
      Hematopoietic stem cells (HSCs) sustain continuous turnover and maintenance of all blood lineages through organismal lifespan. The extensive regenerative potential of HSCs has been harnessed in transplantation medicine ...
    • Identification of small molecules for human hepatocyte expansion and iPS differentiation 

      Shan, Jing; Schwartz, Robert E.; Ross, Nathan T.; Logan, David J.; Thomas, David; Duncan, Stephen A.; North, Trista E.; Goessling, Wolfram; Carpenter, Anne E.; Bhatia, Sangeeta N. (2013)
      Cell-based therapies hold the potential to alleviate the growing burden of liver diseases. Such therapies require human hepatocytes, which, within the stromal context of the liver, are capable of many rounds of replication. ...
    • Prostaglandin E2 Enhances Human Cord Blood Stem Cell Xenotransplants and Shows Long-Term Safety in Preclinical Nonhuman Primate Transplant Models 

      Goessling, Wolfram; Allen, Robyn S.; Guan, Xiao; Jin, Ping; Uchida, Naoya; Dovey, Michael; Harris, James M.; Metzger, Mark E.; Bonifacino, Aylin C.; Stroncek, David; Stegner, Joseph; Armant, Myriam Anne; Schlaeger, Thorsten M.; Tisdale, John F.; Zon, Leonard Ira; Donahue, Robert E.; North, Trista Elizabeth (Elsevier BV, 2011)
      Hematopoietic stem cells (HSCs) are used in transplantation therapy to reconstitute the hematopoietic system. Human cord blood (hCB) transplantation has emerged as an attractive alternative treatment option when traditional ...
    • The Role of Estrogen Signaling in the Induction, Specification, and Proliferation of Hematopoietic Stem Cells 

      Carroll, Kelli Jane (2014-06-06)
      Hematopoietic Stem Cells (HSCs) are characterized by their ability to both self-renew and give rise to all lineages of the blood system. A recent chemical genetic screen identified 17β-estradiol (estrogen) as a novel ...
    • SCF\(^{β-TRCP}\) Suppresses Angiogenesis and Thyroid Cancer Cell Migration by Promoting Ubiquitination and Destruction of VEGF Receptor 2 

      Shaik, Shavali; Nucera, Carmelo; Inuzuka, Hiroyuki; Gao, Daming; Garnaas, Maija; Frechette, Gregory Martin; Harris, Lauren; Wan, Lixin; Fukushima, Hidefumi; Husain, Amjad; Nose, Vania; Fadda, Guido; Sadow, Peter Mark; Goessling, Wolfram; North, Trista Elizabeth; Lawler, Jack William; Wei, Wenyi (The Rockefeller University Press, 2012)
      The incidence of human papillary thyroid cancer (PTC) is increasing and an aggressive subtype of this disease is resistant to treatment with vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor. VEGFR2 promotes ...
    • Single-cell transcriptional analysis of normal, aberrant, and malignant hematopoiesis in zebrafish 

      Moore, Finola E.; Garcia, Elaine G.; Lobbardi, Riadh; Jain, Esha; Tang, Qin; Moore, John C.; Cortes, Mauricio; Molodtsov, Aleksey; Kasheta, Melissa; Luo, Christina C.; Garcia, Amaris J.; Mylvaganam, Ravi; Yoder, Jeffrey A.; Blackburn, Jessica S.; Sadreyev, Ruslan I.; Ceol, Craig J.; North, Trista E.; Langenau, David M. (The Rockefeller University Press, 2016)
      Hematopoiesis culminates in the production of functionally heterogeneous blood cell types. In zebrafish, the lack of cell surface antibodies has compelled researchers to use fluorescent transgenic reporter lines to label ...
    • Teleost Growth Factor Independence (Gfi) Genes Differentially Regulate Successive Waves of Hematopoiesis 

      Cooney, Jeffrey D.; Hildick-Smith, Gordon J.; Shafizadeh, Ebrahim; McBride, Paul F.; Carroll, Kelli Jane; Anderson, Heidi; Shaw, George C.; Tamplin, Owen J.; Branco, Diana S.; Dalton, Arthur J.; Shah, Dhvanit I; Wong, Clara; Gallagher, Patrick G.; Zon, Leonard Ira; North, Trista Elizabeth; Paw, Barry Htin (Elsevier BV, 2013)
      Growth Factor Independence (Gfi) transcription factors play essential roles in hematopoiesis, differentially activating and repressing transcriptional programs required for hematopoietic stem/progenitor cell (HSPC) development ...
    • The Wnt/β-Catenin Pathway Is Required for the Development of Leukemia Stem Cells in AML 

      Wang, Yingzi; Krivtsov, Andrei; Sinha, Amit U.; North, Trista Elizabeth; Goessling, Wolfram; Feng, Zhaohui; Zon, Leonard Ira; Armstrong, Scott (American Association for the Advancement of Science (AAAS), 2010)
      Leukemia stem cells (LSCs) are capable of limitless self-renewal and are responsible for the maintenance of leukemia. Because selective eradication of LSCs could offer substantial therapeutic benefit, there is interest in ...