Now showing items 1-4 of 4

    • Adenomatous Polyposis Coli (APC) Is Required for Normal Development of Skin and Thymus 

      Kuraguchi, Mari; Wang, Xiu-Ping; Rothenberg, Rebecca; Ohene-Baah, Nana Yaw; Lund, Jennifer J; Bronson, Roderick Terry; Kucherlapati, Melanie Haas; Maas, Richard Louis; Kucherlapati, Raju (Public Library of Science, 2006)
      The tumor suppressor gene Apc (adenomatous polyposis coli) is a member of the Wnt signaling pathway that is involved in development and tumorigenesis. Heterozygous knockout mice for Apc have a tumor predisposition phenotype ...
    • An EGFR Targeted PET Imaging Probe for the Detection of Colonic Adenocarcinomas in the Setting of Colitis 

      Turker, N. Selcan; Heidari, Pedram; Kucherlapati, Raju; Kucherlapati, Melanie; Mahmood, Umar (Ivyspring International Publisher, 2014)
      Colorectal cancer is a serious complication associated with inflammatory bowel disease, often indistinguishable by screening with conventional FDG PET probes. We have developed an alternative EGFR-targeted PET imaging probe ...
    • Genotype Directed Therapy in Murine Mismatch Repair Deficient Tumors 

      Kucherlapati, Melanie H.; Esfahani, Shadi; Habibollahi, Peiman; Wang, Junning; Still, Eric R.; Bronson, Roderick T.; Mahmood, Umar; Kucherlapati, Raju S. (Public Library of Science, 2013)
      The PI3K/AKT/mTOR pathway has frequently been found activated in human tumors. We show that in addition to Wnt signaling dysfunction, the PI3K/AKT/mTOR pathway is often upregulated in mouse Msh2−/− initiated intestinal ...
    • Mesalazine and thymoquinone attenuate intestinal tumour development in Msh2loxP/loxP Villin-Cre mice 

      Kortüm, Benedikt; Campregher, Christoph; Lang, Michaela; Khare, Vineeta; Pinter, Matthias; Evstatiev, Rayko; Schmid, Gerald; Mittlböck, Martina; Scharl, Theresa; Kucherlapati, Melanie H; Edelmann, Winfried; Gasche, Christoph (BMJ Publishing Group, 2015)
      Objective: Lynch syndrome is caused by germline mutations in DNA mismatch repair genes leading to microsatellite instability (MSI) and colorectal cancer. Mesalazine, commonly used for the treatment of UC, reduces MSI in ...