Now showing items 1-4 of 4

    • Confirmation of emergence of mutations associated with atovaquone-proguanil resistance in unexposed Plasmodium falciparum isolates from Africa 

      Happi, Christian Tientcha; Gbotosho, Grace O; Folarin, Onikepe A; Milner, Danny Arnold; Sarr, Ousmane; Sowunmi, Akintunde; Kyle, Dennis E; Milhous, Wilbur K; Wirth, Dyann Fergus; Oduola, Ayoade MJ (BioMed Central, 2006)
      Background: In vitro and in vivo resistance of Plasmodium falciparum to atovaquone or atovaquone-proguanil hydrochloride combination has been associated to two point mutations in the parasite cytochrome b (cytb) gene ...
    • Identification and Functional Validation of the Novel Antimalarial Resistance Locus PF10_0355 in Plasmodium falciparum 

      Van Tyne, Daria Natalie; Park, Daniel John; Schaffner, Stephen; Neafsey, Daniel Edward; Angelino, Elaine Lee; Cortese, Joseph F.; Barnes, Kayla G.; Rosen, David M.; Lukens, Amanda Kathleen; Daniels, Rachel Fath; Milner, Danny Arnold; Johnson, Charles A.; Shlyakhter, Ilya; Grossman, Sharon Rachel; Becker, Justin S.; Yamins, Daniel Louis Kanef; Karlsson, Elinor Kathryn; Ndiaye, Daouda; Sarr, Ousmane; Mboup, Souleymane; Happi, Christian Tientcha; Furlotte, Nicholas A.; Eskin, Eleazar; Kang, Hyun Min; Hartl, Daniel L.; Birren, Bruce W.; Wiegand, Roger C.; Lander, Eric Steven; Wirth, Dyann Fergus; Cooke, Sarah Volkman; Sabeti, Pardis Christine (Public Library of Science, 2011)
      The Plasmodium falciparum parasite's ability to adapt to environmental pressures, such as the human immune system and antimalarial drugs, makes malaria an enduring burden to public health. Understanding the genetic basis ...
    • In vivo transcriptional profiling of Plasmodium falciparum 

      Daily, Johanna P; Le Roch, Karine G; Sarr, Ousmane; Fang, Xuemin; Zhou, Yingyao; Ndir, Omar; Mboup, Soulyemane; Sultan, Ali; Winzeler, Elizabeth A; Wirth, Dyann Fergus (BioMed Central, 2004)
      Background: Both host and pathogen factors contribute to disease outcome in Plasmodium falciparum infection. The feasibility of studying the P. falciparum in vivo transcriptome to understand parasite transcriptional response ...
    • A Systematic Map of Genetic Variation in Plasmodium falciparum 

      Kidgell, Claire; Daily, Johanna; Borevitz, Justin O; Plouffe, David; Zhou, Yingyao; Le Roch, Karine G.; Ndir, Omar; Mboup, Soulyemane; Batalov, Serge; Winzeler, Elizabeth A; Volkman, Sarah K.; Johnson, Jeffrey R.; Sarr, Ousmane; Wirth, Dyann Fergus (Public Library of Science, 2006)
      Discovering novel genes involved in immune evasion and drug resistance in the human malaria parasite, Plasmodium falciparum, is of critical importance to global health. Such knowledge may assist in the development of new ...