Browsing by Author "Moir, Robert"

Now showing items 1-8 of 8

    • Alzheimer's Disease Amyloid-\(\beta\) Links Lens and Brain Pathology in Down Syndrome 

      Moncaster, Juliet A.; Lu, Suqian; Burton, Mark A.; Ghosh, Joy G.; Soscia, Stephanie J.; Mocofanescu, Anca; Kuszak, Jer R.; Pineda, Roberto; Moir, Robert D.; Ericsson, Maria; Folkerth, Rebecca Dunn; Robb, Richard Moore; Clark, John I.; Tanzi, Rudolph Emile; Hunter, David; Goldstein, Lee David (Public Library of Science, 2010)
      Down syndrome (DS, trisomy 21) is the most common chromosomal disorder and the leading genetic cause of intellectual disability in humans. In DS, triplication of chromosome 21 invariably includes the APP gene (21q21) ...

    • The Alzheimer's Disease-Associated Amyloid \(\beta\)-Protein Is an Antimicrobial Peptide 

      Soscia, Stephanie; Kirby, James Edward; Washicosky, Kevin J.; Tucker, Stephanie; Ingelsson, Martin; Hyman, Bradley Theodore; Burton, Mark A.; Duong, Scott; Tanzi, Rudolph Emile; Moir, Robert D.; Goldstein, Lee E. (Public Library of Science, 2010)
      Background: The amyloid \(\beta\)-protein (A\(\beta\)) is believed to be the key mediator of Alzheimer's disease (AD) pathology. A\(\beta\) is most often characterized as an incidental catabolic byproduct that lacks a ...

    • The Alzheimer’s Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide 

      Kirby, James Edward; Washicosky, Kevin J.; Tucker, Stephanie M.; Ingelsson, Martin; Hyman, Bradley Theodore; Burton, Mark A.; Goldstein, Lee E.; Duong, Scott; Tanzi, Rudolph Emile; Moir, Robert D. (Public Library of Science, 2010)
      Background: The amyloid β-protein (Aβ) is believed to be the key mediator of Alzheimer's disease (AD) pathology. Aβ is most often characterized as an incidental catabolic byproduct that lacks a normal physiological role. ...

    • Amyloid-β Protein Protects Against Microbial Infection In Transgenic C. elegans and 5XFAD Mice 

      Kumar, Deepak; Choi, Se Hoon; Washicosky, Kevin J.; Eimer, William; Tucker, Stephanie Catherine; Ghofrani, Jessica; Lefkowitz, Aaron; McColl, Gawain; Goldstein, Lee E.; Tanzi, Rudolph Emile; Moir, Robert D. (American Association for the Advancement of Science (AAAS), 2016)
      The amyloid-β peptide (Aβ) is a key protein in Alzheimer's disease (AD) pathology. We previously reported in vitro evidence suggesting Aβ is an antimicrobial peptide. Here we provide the first in vivo evidence showing high ...

    • Characterization of a Drosophila Alzheimer's Disease Model: Pharmacological Rescue of Cognitive Defects 

      Chakraborty, Ranjita; Vepuri, Vidya; Mhatre, Siddhita D.; Paddock, Brie E.; Miller, Sean; Michelson, Sarah J.; Delvadia, Radha; Desai, Arkit; Vinokur, Marianna; Melicharek, David J.; Utreja, Suruchi; Khandelwal, Preeti; Ansaloni, Sara; Lee, Jeremy C.; Tabb, Loni P.; Saunders, Aleister J.; Marenda, Daniel R.; Goldstein, Lee E.; Moir, Robert D. (Public Library of Science, 2011)
      Transgenic models of Alzheimer's disease (AD) have made significant contributions to our understanding of AD pathogenesis, and are useful tools in the development of potential therapeutics. The fruit fly, Drosophila ...

    • Isoflurane-Induced Apoptosis: A Potential Pathogenic Link Between Delirium and Dementia 

      Xie, Zhongcong; Dong, Y.; Maeda, U.; Moir, Robert D.; Inouye, Sharon; Culley, Deborah Jean; Crosby, Gregory; Tanzi, Rudolph Emile (Oxford University Press (OUP), 2006)
      Background. Dementia and delirium have been postulated to share common pathophysiologic mechanisms; however, identification of these unifying mechanisms has remained elusive. The inhalation anesthetic isoflurane has been ...

    • Peroxidase Activity of Cyclooxygenase-2 (COX-2) Cross-links β-Amyloid (Aβ) and Generates Aβ-COX-2 Hetero-oligomers That Are Increased in Alzheimer's Disease 

      Nagano, Seiichi; Huang, Xudong; Payton, Sandra M.; Tanzi, Rudolph E.; Bush, Ashley I.; Moir, Robert (American Society for Biochemistry & Molecular Biology (ASBMB), 2004-01-14)
      Oxidative stress is associated with the neuropathology of Alzheimer's disease. We have previously shown that human Abeta has the ability to reduce Fe(III) and Cu(II) and produce hydrogen peroxide coupled with these metals, ...

    • Zinc-induced Alzheimer's Aβ1–40 Aggregation Is Mediated by Conformational Factors 

      Atwood, Craig S.; Hartshorn, Mariana A.; Vonsattel, Jean-Paul; Huang, Xudong; Moir, Robert; Tanzi, Rudolph; Bush, Ashley (American Society for Biochemistry & Molecular Biology (ASBMB), 1997-10-17)
      The heterogeneous precipitates of Aβ that accumulate in the brain cortex in Alzheimer's disease possess varying degrees of resistance to resolubilization. We previously found that Aβ1–40 is rapidly precipitated in vitro ...