Now showing items 1-5 of 5

    • Alzheimer's Disease Amyloid-\(\beta\) Links Lens and Brain Pathology in Down Syndrome 

      Moncaster, Juliet A.; Lu, Suqian; Burton, Mark A.; Ghosh, Joy G.; Soscia, Stephanie J.; Mocofanescu, Anca; Kuszak, Jer R.; Pineda, Roberto; Moir, Robert D.; Ericsson, Maria; Folkerth, Rebecca Dunn; Robb, Richard Moore; Clark, John I.; Tanzi, Rudolph Emile; Hunter, David; Goldstein, Lee David (Public Library of Science, 2010)
      Down syndrome (DS, trisomy 21) is the most common chromosomal disorder and the leading genetic cause of intellectual disability in humans. In DS, triplication of chromosome 21 invariably includes the APP gene (21q21) ...
    • The Alzheimer's Disease-Associated Amyloid \(\beta\)-Protein Is an Antimicrobial Peptide 

      Soscia, Stephanie; Kirby, James Edward; Washicosky, Kevin J.; Tucker, Stephanie; Ingelsson, Martin; Hyman, Bradley Theodore; Burton, Mark A.; Duong, Scott; Tanzi, Rudolph Emile; Moir, Robert D.; Goldstein, Lee E. (Public Library of Science, 2010)
      Background: The amyloid \(\beta\)-protein (A\(\beta\)) is believed to be the key mediator of Alzheimer's disease (AD) pathology. A\(\beta\) is most often characterized as an incidental catabolic byproduct that lacks a ...
    • The Alzheimer’s Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide 

      Kirby, James Edward; Washicosky, Kevin J.; Tucker, Stephanie M.; Ingelsson, Martin; Hyman, Bradley Theodore; Burton, Mark A.; Goldstein, Lee E.; Duong, Scott; Tanzi, Rudolph Emile; Moir, Robert D. (Public Library of Science, 2010)
      Background: The amyloid β-protein (Aβ) is believed to be the key mediator of Alzheimer's disease (AD) pathology. Aβ is most often characterized as an incidental catabolic byproduct that lacks a normal physiological role. ...
    • Amyloid-β Protein Protects Against Microbial Infection In Transgenic C. elegans and 5XFAD Mice 

      Kumar, Deepak; Choi, Se Hoon; Washicosky, Kevin J.; Eimer, William; Tucker, Stephanie Catherine; Ghofrani, Jessica; Lefkowitz, Aaron; McColl, Gawain; Goldstein, Lee E.; Tanzi, Rudolph Emile; Moir, Robert D. (American Association for the Advancement of Science (AAAS), 2016)
      The amyloid-β peptide (Aβ) is a key protein in Alzheimer's disease (AD) pathology. We previously reported in vitro evidence suggesting Aβ is an antimicrobial peptide. Here we provide the first in vivo evidence showing high ...
    • Characterization of a Drosophila Alzheimer's Disease Model: Pharmacological Rescue of Cognitive Defects 

      Chakraborty, Ranjita; Vepuri, Vidya; Mhatre, Siddhita D.; Paddock, Brie E.; Miller, Sean; Michelson, Sarah J.; Delvadia, Radha; Desai, Arkit; Vinokur, Marianna; Melicharek, David J.; Utreja, Suruchi; Khandelwal, Preeti; Ansaloni, Sara; Lee, Jeremy C.; Tabb, Loni P.; Saunders, Aleister J.; Marenda, Daniel R.; Goldstein, Lee E.; Moir, Robert D. (Public Library of Science, 2011)
      Transgenic models of Alzheimer's disease (AD) have made significant contributions to our understanding of AD pathogenesis, and are useful tools in the development of potential therapeutics. The fruit fly, Drosophila ...