Browsing by Author "Lockley, Steven"

Now showing items 1-9 of 9

    • Analysis Method and Experimental Conditions Affect Computed Circadian Phase from Melatonin Data 

      Klerman, Hadassa; St. Hilaire, Melissa A.; Gronfier, Claude; Santhi, Nayantara; Kronauer, Richard E.; Gooley, Joshua James; Hull, Joseph Thomas; Lockley, Steven Ward; Wang, Wei; Klerman, Elizabeth Beryl (Public Library of Science, 2012)
      Accurate determination of circadian phase is necessary for research and clinical purposes because of the influence of the master circadian pacemaker on multiple physiologic functions. Melatonin is presently the most accurate ...

    • Effect of Reducing Interns' Work Hours on Serious Medical Errors in Intensive Care Units 

      Landrigan, Christopher; Rothschild, Jeffrey; Cronin, John W.; Kaushal, Rainu; Burdick, Elisabeth; Katz, Joel; Lilly, Craig M.; Stone, Peter; Lockley, Steven; Bates, David; Czeisler, Charles (Massachusetts Medical Society, 2004-10-28)
      BACKGROUND Although sleep deprivation has been shown to impair neurobehavioral performance, few studies have measured its effects on medical errors. METHODS We conducted a prospective, randomized study comparing the ...

    • Implementing a Sleep Health Education and Sleep Disorders Screening Program in Fire Departments: A Comparison of Methodology 

      Barger, Laura K.; O’Brien, Conor S.; Rajaratnam, Shantha M.W.; Qadri, Salim; Sullivan, Jason P.; Wang, Wei; Czeisler, Charles A.; Lockley, Steven W. (Lippincott Williams & Wilkins, 2016)
      Objective: The objective of this study is to compare three methods of administering a sleep health program (SHP) in fire departments. Methods: An SHP, comprising sleep health education and screening for common sleep ...

    • Inter-Individual Differences in Neurobehavioural Impairment following Sleep Restriction Are Associated with Circadian Rhythm Phase 

      Sletten, Tracey L.; Segal, Ahuva Y.; Flynn-Evans, Erin E.; Lockley, Steven W.; Rajaratnam, Shantha M. W. (Public Library of Science, 2015)
      Although sleep restriction is associated with decrements in daytime alertness and neurobehavioural performance, there are considerable inter-individual differences in the degree of impairment. This study examined the effects ...

    • Meeting Report: The Role of Environmental Lighting and Circadian Disruption in Cancer and Other Diseases 

      Stevens, Richard G.; Blask, David E.; Brainard, George C.; Hansen, Johnni; Lockley, Steven Ward; Provencio, Ignacio; Rea, Mark S.; Reinlib, Leslie (National Institute of Environmental Health Sciences, 2007)
      Light, including artificial light, has a range of effects on human physiology and behavior and can therefore alter human physiology when inappropriately timed. One example of potential light-induced disruption is the effect ...

    • Ocular exposure to blue-enriched light has an asymmetric influence on neural activity and spatial attention 

      Newman, Daniel P.; Lockley, Steven W.; Loughnane, Gerard M.; Martins, Ana Carina P.; Abe, Rafael; Zoratti, Marco T. R.; Kelly, Simon P.; O’Neill, Megan H.; Rajaratnam, Shantha M. W.; O’Connell, Redmond G.; Bellgrove, Mark A. (Nature Publishing Group, 2016)
      Brain networks subserving alertness in humans interact with those for spatial attention orienting. We employed blue-enriched light to directly manipulate alertness in healthy volunteers. We show for the first time that ...

    • The Physiological Period Length of the Human Circadian Clock In Vivo is Directly Proportional to Period in Human Fibroblasts 

      Pagani, Lucia; Semenova, Ekaterina A.; Moriggi, Ermanno; Revell, Victoria L.; Hack, Lisa M.; Arendt, Josephine; Skene, Debra J.; Meier, Fides; Izakovic, Jan; Wirz-Justice, Anna; Cajochen, Christian; Sergeeva, Oksana J.; Cheresiz, Sergei V.; Danilenko, Konstantin V.; Eckert, Anne; Reif, Andreas; Lockley, Steven Ward; Brown, Steven A. (Public Library of Science, 2010)
      Background: Diurnal behavior in humans is governed by the period length of a circadian clock in the suprachiasmatic nuclei of the brain hypothalamus. Nevertheless, the cell-intrinsic mechanism of this clock is present in ...

    • The relationship between sleep and behavior in autism spectrum disorder (ASD): a review 

      Cohen, Simonne; Conduit, Russell; Lockley, Steven W; Rajaratnam, Shantha MW; Cornish, Kim M (BioMed Central, 2014)
      Although there is evidence that significant sleep problems are common in children with autism spectrum disorder (ASD) and that poor sleep exacerbates problematic daytime behavior, such relationships have received very ...

    • Short-Wavelength Light Sensitivity of Circadian, Pupillary, and Visual Awareness in Humans Lacking an Outer Retina 

      Zaidi, Farhan H.; Peirson, Stuart N.; Wulff, Katharina; Brainard, George C.; Gregory-Evans, Kevin; Moseley, Merrick J.; Hull, Joseph Thomas; Aeschback, Daniel; Gooley, Joshua James; Rizzo, Joseph F.; Czeisler, Charles Andrew; Foster, Russell G.; Lockley, Steven Ward (Cell Press, 2007)
      Summary As the ear has dual functions for audition and balance, the eye has a dual role in detecting light for a wide range of behavioral and physiological functions separate from sight [1–11]. These responses are driven ...