Now showing items 1-20 of 27

    • Ambient Air Pollution and Atherosclerosis: The Framingham Heart Study 

      Dorans, Kirsten Sandstrom (2016-04-25)
      This dissertation assesses the associations of residential proximity to a major roadway and residential ambient fine particulate matter exposure with artery calcification, a correlate of atherosclerosis, among Framingham ...
    • Ambient Air Pollution and Depressive Symptoms in Older Adults: Results from the MOBILIZE Boston Study 

      Wang, Yi; Eliot, Melissa N.; Koutrakis, Petros; Gryparis, Alexandros; Schwartz, Joel D.; Coull, Brent A.; Mittleman, Murray A.; Milberg, William P.; Lipsitz, Lewis A.; Wellenius, Gregory A. (NLM-Export, 2014)
      Background: Exposure to ambient air pollution, particularly from traffic, has been associated with adverse cognitive outcomes, but the association with depressive symptoms remains unclear. Objectives: We investigated the ...
    • Ambient Air Pollution, Adiposity, and Hepatic Steatosis: The Framingham Heart Study 

      Li, Wenyuan (2016-05-03)
      Air pollution-induced systemic inflammation and oxidative stress are among potential underlying mechanisms that mediate the associations between air pollution and metabolic risk factors such as obesity and insulin resistance. ...
    • Ambient Temperature and Biomarkers of Heart Failure: A Repeated Measures Analysis 

      Wilker, Elissa Hope; Yeh, Gloria Y.; Wellenius, Gregory Alexander; Davis, Roger B.; Phillips, Russell Scott; Mittleman, Murray A. (National Institute of Environmental Health Sciences, 2012)
      Background: Extreme temperatures have been associated with hospitalization and death among individuals with heart failure, but few studies have explored the underlying mechanisms. Objectives: We hypothesized that outdoor ...
    • Autonomic Effects of Controlled Fine Particulate Exposure in Young Healthy Adults: Effect Modification by Ozone 

      Fakhri, Asghar A.; Ilic, Ljubomir M.; Wellenius, Gregory A.; Urch, Bruce; Silverman, Frances; Gold, Diane R.; Mittleman, Murray A. (National Institute of Environmental Health Sciences, 2009)
      Background: Human controlled-exposure studies have assessed the impact of ambient fine particulate matter on cardiac autonomic function measured by heart rate variability (HRV), but whether these effects are modified by ...
    • Brachial Artery Responses to Ambient Pollution, Temperature, and Humidity in People with Type 2 Diabetes: A Repeated-Measures Study 

      Zanobetti, Antonella; Luttmann-Gibson, Heike; Horton, Edward S.; Cohen, Allison; Coull, Brent A.; Hoffmann, Barbara; Schwartz, Joel D.; Mittleman, Murray A.; Li, Yongsheng; Stone, Peter H.; de Souza, Celine; Lamparello, Brooke; Koutrakis, Petros; Gold, Diane R. (National Institute of Environmental Health Sciences, 2014)
      Background: Extreme weather and air pollution are associated with increased cardiovascular risk in people with diabetes. Objectives: In a population with diabetes, we conducted a novel assessment of vascular brachial artery ...
    • A Case–Control Analysis of Exposure to Traffic and Acute Myocardial Infarction 

      Tonne, Cathryn; Melly, Steven John; Mittleman, Murray A.; Coull, Brent Andrew; Goldberg, Robert; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2006)
      Background: Long-term exposure to particulate air pollution has been associated with an increased risk of dying from cardiopulmonary and ischemic heart disease, yet few studies have evaluated cardiovascular end points other ...
    • Chimney Stove Intervention to Reduce Long-term Wood Smoke Exposure Lowers Blood Pressure among Guatemalan Women 

      McCracken, John Patrick; Smith, Kirk R.; Díaz, Anaité; Mittleman, Murray A.; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2007)
      Background and Objective: RESPIRE, a randomized trial of an improved cookstove, was conducted in Guatemala to assess health effects of long-term reductions in wood smoke exposure. Given the evidence that ambient particles ...
    • Controlled Exposure Study of Air Pollution and T-Wave Alternans in Volunteers without Cardiovascular Disease 

      Kusha, Marjan; Masse, Stephane; Farid, Talha; Urch, Bruce; Silverman, Frances; Brook, Robert D; Mangat, Iqwal; Speck, Mary; Nair, Krishnakumar; Poku, Kwaku; Wellenius, Gregory A; Nanthakumar, Kumaraswamy; Gold, Diane R.; Chris, Meyer; Mittleman, Murray A. (National Institute of Environmental Health Sciences, 2012)
      Background: Epidemiological studies have assessed T-wave alternans (TWA) as a possible mechanism of cardiac arrhythmias related to air pollution in high-risk subjects and have reported associations with increased TWA ...
    • Effects of Ambient Air Pollution on Functional Status in Patients with Chronic Congestive Heart Failure: a Repeated-Measures Study 

      Wellenius, Gregory A.; Yeh, Gloria Y.; Coull, Brent Andrew; Suh MacIntosh, Helen H.; Phillips, Russell Scott; Mittleman, Murray A. (BioMed Central, 2007)
      Background: Studies using administrative data report a positive association between ambient air pollution and the risk of hospitalization for congestive heart failure (HF). Circulating levels of B-type natriuretic peptide ...
    • Healthcare-Related Regret among Nurses and Physicians Is Associated with Self-Rated Insomnia Severity: A Cross-Sectional Study 

      Schmidt, Ralph E.; Cullati, Stephane; Mostofsky, Elizabeth; Haller, Guy; Agoritsas, Thomas; Mittleman, Murray A.; Perneger, Thomas V.; Courvoisier, Delphine S. (Public Library of Science, 2015)
      To examine the association between healthcare-related regrets and sleep difficulties among nurses and physicians, we surveyed 240 nurses and 220 physicians at the University Hospitals of Geneva. Regret intensity and regret ...
    • Increased Risk of Paroxysmal Atrial Fibrillation Episodes Associated with Acute Increases in Ambient Air Pollution 

      Rich, David Q.; Mittleman, Murray A.; Link, Mark S.; Schwartz, Joel David; Luttmann-Gibson, Heike; Catalano, Paul J.; Speizer, Frank Erwin; Gold, Diane R.; Dockery, Douglas W. (National Institute of Environmental Health Sciences, 2006)
      Objectives: We reported previously that 24-hr moving average ambient air pollution concentrations were positively associated with ventricular arrhythmias detected by implantable cardioverter defibrillators (ICDs). ICDs ...
    • Infectious Disease in a Warming World: How Weather Influenced West Nile Virus in the United States (2001–2005) 

      Soverow, Jonathan Edward; Wellenius, Gregory A.; Fisman, David N.; Mittleman, Murray A. (National Institute of Environmental Health Sciences, 2009)
      Background: The effects of weather on West Nile virus (WNV) mosquito populations in the United States have been widely reported, but few studies assess their overall impact on transmission to humans. Objectives: We ...
    • Long-term Exposure to \(PM_{2.5}\) and Incidence of Acute Myocardial Infarction 

      Madrigano, Jaime; Kloog, Itai; Goldberg, Robert; Coull, Brent Andrew; Mittleman, Murray A.; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2013)
      Background: A number of studies have shown associations between chronic exposure to particulate air pollution and increased mortality, particularly from cardiovascular disease, but fewer studies have examined the association ...
    • Long-term Exposure to Black Carbon and Carotid Intima-Media Thickness: The Normative Aging Study 

      Wilker, Elissa H.; Mittleman, Murray A.; Coull, Brent A.; Gryparis, Alexandros; Bots, Michiel L.; Schwartz, Joel; Sparrow, David (National Institute of Environmental Health Sciences, 2013)
      Background: Evidence suggests that air pollution is associated with atherosclerosis and that traffic-related particles are a particularly important contributor to the association. Objectives: We investigated the association ...
    • Obesity and undiagnosed diabetes in the U.S. 

      Wee, Christina C.; Hamel, Mary Beth; Huang, Annong; Davis, Robert B.; Mittleman, Murray A.; McCarthy, Ellen Patricia (American Diabetes Association, 2008)
      OBJECTIVE—To study whether obese individuals, who are at higher risk for diabetes and disparities in care than nonobese individuals, are more likely to have undiagnosed diabetes. RESEARCH DESIGN AND METHODS—We performed ...
    • Opposing Effects of Particle Pollution, Ozone, and Ambient Temperature on Arterial Blood Pressure 

      Luttmann-Gibson, Heike; de Souza, Celine; Foley, Christopher; Hoffmann, Barbara H.; Cohen, Allison Leigh; Zanobetti, Antonella; Suh MacIntosh, Helen H.; Coull, Brent Andrew; Schwartz, Joel David; Mittleman, Murray A.; Stone, Peter Howard; Horton, Edward S.; Gold, Diane R. (National Institute of Environmental Health Sciences, 2012)
      Background: Diabetes increases the risk of hypertension and orthostatic hypotension and raises the risk of cardiovascular death during heat waves and high pollution episodes. Objective: We examined whether short-term ...
    • Postural Changes in Blood Pressure Associated with Interactions between Candidate Genes for Chronic Respiratory Diseases and Exposure to Particulate Matter 

      Wilker, Elissa Hope; Mittleman, Murray A.; Litonjua, Augusto Ampil; Poon, Audrey; Baccarelli, Andrea; Suh, Helen; Wright, Robert O.; Sparrow, David; Vokonas, Pantel S; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2009)
      Background: Fine particulate matter [aerodynamic diameter ≤ 2.5 μm (PM2.5)] has been associated with autonomic dysregulation.Objective We hypothesized that PM2.5 influences postural changes in systolic blood pressure (ΔSBP) ...
    • Predicting DNA methylation level across human tissues 

      Ma, Baoshan; Wilker, Elissa H.; Willis-Owen, Saffron A. G.; Byun, Hyang-Min; Wong, Kenny C. C.; Motta, Valeria; Baccarelli, Andrea A.; Schwartz, Joel; Cookson, William O. C. M.; Khabbaz, Kamal; Mittleman, Murray A.; Moffatt, Miriam F.; Liang, Liming (Oxford University Press, 2014)
      Differences in methylation across tissues are critical to cell differentiation and are key to understanding the role of epigenetics in complex diseases. In this investigation, we found that locus-specific methylation ...
    • Prenatal Air Pollution Exposure and Newborn Blood Pressure 

      van Rossem, Lenie; Rifas-Shiman, Sheryl L.; Melly, Steven J.; Kloog, Itai; Luttmann-Gibson, Heike; Zanobetti, Antonella; Coull, Brent A.; Schwartz, Joel D.; Mittleman, Murray A.; Oken, Emily; Gillman, Matthew W.; Koutrakis, Petros; Gold, Diane R. (NLM-Export, 2015)
      Background: Air pollution exposure has been associated with increased blood pressure in adults. Objective: We examined associations of antenatal exposure to ambient air pollution with newborn systolic blood pressure (SBP). ...