Now showing items 1-4 of 4

    • BRAF V600E Mutations are Common in Pleomorphic Xanthoastrocytoma: Diagnostic and Therapeutic Implications 

      Lam, Quynh; Vernovsky, Kathy; Vena, Natalie; Lennerz, Jochen K.; Dias-Santagata, Dora; Borger, Darrell R.; Batchelor, Tracy Todd; Ligon, Keith Lloyd; Iafrate, Anthony John; Ligon, Azra Hadi; Louis, David Neil; Santagata, Sandro; Dias-Santagata, Dora (Public Library of Science, 2011)
      Pleomorphic xanthoastrocytoma (PXA) is low-grade glial neoplasm principally affecting children and young adults. Approximately 40% of PXA are reported to recur within 10 years of primary resection. Upon recurrence, patients ...
    • Genomic characterization of brain metastases identifies drivers of metastatic lung adenocarcinoma 

      Shih, David; Nayyar, Naema; Bihun, Ivanna; Dagogo-Jack, Ibiayi; Gill, Corey; Aquilanti, Elisa; Bertalan, Mia; Kaplan, Alexander; Chukwueke, Ugonma; Ippen, Franziska; Alvarez-Breckenridge, Christopher; Camarda, Nicholas; Lastrapes, Matthew; McCabe, Devin; Kuter, Ben; Kaufmann, Benjamin; Strickland, Matthew; Martinez-Gutierrez, Juan Carlos; Nagabhushan, Deepika; De Sauvage, Magali; White, Michael; Castro, Brandyn; Hoang, Kaitlin; Kaneb, Andrew; Batchelor, Emily; Paek, Sun Ha; Park, Sun Hye; Martinez-Lage Alvarez, Maria; Berghoff, Anna S.; Merrill, Parker; Gerstner, Elizabeth; Batchelor, Tracy; Frosch, Matthew; Frazier, Ryan P.; Borger, Darrell; Iafrate, Anthony; Johnson, Bruce E.; Santagata, Sandro; Preusser, Matthias; Cahill, Daniel; Carter, Scott; Brastianos, Priscilla (Elsevier BV, 2020-06)
    • Rapid targeted mutational analysis of human tumours: a clinical platform to guide personalized cancer medicine 

      Dias-Santagata, Dora; Akhavanfard, Sara; David, Serena S; Vernovsky, Kathy; Kuhlmann, Georgiana; Boisvert, Susan L; Stubbs, Hannah; McDermott, Ultan; Settleman, Jeffrey; Kwak, Eunice Lee; Clark, Jeffrey William; Isakoff, Steven Jay; Sequist, Lecia VanDam; Engelman, Jeffrey Adam; Lynch, Thomas J; Haber, Daniel Arie; Louis, David Neil; Ellisen, Leif William; Borger, Darrell R.; Iafrate, Anthony John (WILEY-VCH Verlag, 2010)
      Targeted cancer therapy requires the rapid and accurate identification of genetic abnormalities predictive of therapeutic response. We sought to develop a high-throughput genotyping platform that would allow prospective ...
    • RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer 

      Niederst, Matthew J.; Sequist, Lecia V.; Poirier, John T.; Mermel, Craig H.; Lockerman, Elizabeth L.; Garcia, Angel R.; Katayama, Ryohei; Costa, Carlotta; Ross, Kenneth N.; Moran, Teresa; Howe, Emily; Fulton, Linnea E.; Mulvey, Hillary E.; Bernardo, Lindsay A.; Mohamoud, Farhiya; Miyoshi, Norikatsu; VanderLaan, Paul A.; Costa, Daniel B.; Jänne, Pasi A.; Borger, Darrell R.; Ramaswamy, Sridhar; Shioda, Toshi; Iafrate, Anthony J.; Getz, Gad; Rudin, Charles M.; Mino-Kenudson, Mari; Engelman, Jeffrey A. (Nature Pub. Group, 2015)
      Tyrosine kinase inhibitors are effective treatments for non-small-cell lung cancers (NSCLCs) with epidermal growth factor receptor (EGFR) mutations. However, relapse typically occurs after an average of 1 year of continuous ...