Browsing by Author "Shen, Jie"
Now showing items 1-10 of 10
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Absence of Dopaminergic Neuronal Degeneration and Oxidative Damage in Aged DJ-1-deficient Mice
Yamaguchi, Hiroo; Shen, Jie (BioMed Central, 2007)Parkinson's disease is the most common movement disorder characterized by dopaminergic dysfunction and degeneration. Loss-of-function mutations in the DJ-1 gene have been linked to autosomal recessive forms of early-onset ... -
Cambogin is Preferentially Cytotoxic to Cells Expressing PDGFR
Tian, Ze; Shen, Jie; Wang, Fengfei; Xiao, Peigen; Yang, Junshan; Lei, Hetian; Kazlauskas, Andrius; Kohane, Isaac Samuel; Wu, Erxi (Public Library of Science, 2011)Platelet-derived growth factor receptors (PDGFRs) have been implicated in a wide array of human malignancies, including medulloblastoma (MB), the most common brain tumor of childhood. Although significant progress in MB ... -
Characterization of Age-Dependent and Progressive Cortical Neuronal Degeneration in Presenilin Conditional Mutant Mice
Wines-Samuelson, Mary; Schulte, Eva C.; Smith, Miriam J.; Aoki, Chiye; Liu, Xinran; Cookson, Mark R.; Kelleher, Raymond J.; Shen, Jie (Public Library of Science, 2010)Presenilins are the major causative genes of familial Alzheimer's disease (AD). Our previous study has demonstrated essential roles of presenilins in memory and neuronal survival. Here, we explore further how loss of ... -
Loss of DJ-1 Does Not Affect Mitochondrial Respiration but Increases ROS Production and Mitochondrial Permeability Transition Pore Opening
Giaime, Emilie; Yamaguchi, Hiroo; Gautier, Clement A.; Kitada, Tohru; Shen, Jie (Public Library of Science, 2012)Background: Loss of function mutations in the DJ-1 gene have been linked to recessively inherited forms of Parkinsonism. Mitochondrial dysfunction and increased oxidative stress are thought to be key events in the pathogenesis ... -
Loss of Leucine-rich Repeat Kinase 2 Causes Age-dependent Bi-phasic Alterations of the Autophagy Pathway
Tong, Youren; Giaime, Emilie; Yamaguchi, Hiroo; Ichimura, Takaharu; Liu, Yumin; Si, Huiqing; Cai, Huaibin; Bonventre, Joseph Vincent; Shen, Jie (BioMed Central, 2012)Background: Dominantly inherited missense mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease, but its normal physiological function remains unclear. We previously ... -
PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin
Narendra, Derek P.; Jin, Seok Min; Tanaka, Atsushi; Suen, Der-Fen; Gautier, Clement A.; Shen, Jie; Cookson, Mark R.; Youle, Richard J. (Public Library of Science, 2010)Loss-of-function mutations in PINK1 and Parkin cause parkinsonism in humans and mitochondrial dysfunction in model organisms. Parkin is selectively recruited from the cytosol to damaged mitochondria to trigger their ... -
Presenilins are Required for Maintenance of Neural Stem Cells in the Developing Brain
Kim, Woo-Young; Shen, Jie (BioMed Central, 2008)The early embryonic lethality of mutant mice bearing germ-line deletions of both presenilin genes precluded the study of their functions in neural development. We therefore employed the Cre-loxP technology to generate ... -
Presenilins in Alzheimer’s Disease and Frontotemporal Dementia
Shen, Jie (BioMed Central, 2012) -
Regulation of mitochondrial permeability transition pore by PINK1
Giaime, Emilie; Caballero, Erica; Núñez, Lucía; Song, Zhiyin; Chan, David; Villalobos, Carlos; Shen, Jie (BioMed Central, 2012)Background: Loss-of-function mutations in PTEN-induced kinase 1 (PINK1) have been linked to familial Parkinson’s disease, but the underlying pathogenic mechanism remains unclear. We previously reported that loss of PINK1 ... -
Transcriptional Activation of Low-Density Lipoprotein Receptor Gene by DJ-1 and Effect of DJ-1 on Cholesterol Homeostasis
Yamaguchi, Shiori; Yamane, Takuya; Takahashi-Niki, Kazuko; Kato, Izumi; Niki, Takeshi; Goldberg, Matthew S.; Ishimoto, Kenji; Doi, Takefumi; Iguchi-Ariga, Sanae M. M.; Ariga, Hiroyoshi; Shen, Jie (Public Library of Science, 2012)DJ-1 is a novel oncogene and also causative gene for familial Parkinson’s disease park7. DJ-1 has multiple functions that include transcriptional regulation, anti-oxidative reaction and chaperone and mitochondrial regulation. ...