Browsing by Author "Libby, Peter"
Now showing items 1-20 of 116
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Adenovirus-mediated gene transfer into normal rabbit arteries results in prolonged vascular cell activation, inflammation, and neointimal hyperplasia
Newman, K D; Dunn, Peter Francis; Owens, J W; Schulick, A H; Virmani, R; Sukhova, Galina K.; Libby, Peter; Dichek, D A (American Society for Clinical Investigation, 1995)Adenovirus vectors are capable of high efficiency in vivo arterial gene transfer, and are currently in use as therapeutic agents in animal models of vascular disease. However, despite substantial data on the ability of ... -
Adiponectin Deficiency Increases Allergic Airway Inflammation and Pulmonary Vascular Remodeling
Medoff, Benjamin D.; Okamoto, Yoshihisa; Leyton, Patricio; Weng, Meiqian; Sandall, Barry P.; Raher, Michael J.; Kihara, Shinji; Bloch, Kenneth Daniel; Libby, Peter; Luster, Andrew David (American Thoracic Society, 2009)Obesity is associated with an increased incidence and severity of asthma, as well as other lung disorders, such as pulmonary hypertension. Adiponectin (APN), an antiinflammatory adipocytokine, circulates at lower levels ... -
Adiponectin inhibits macrophage tissue factor, a key trigger of thrombosis in disrupted atherosclerotic plaques
Okamoto, Yoshihisa; Ishii, So; Croce, Kevin James; Katsumata, Harumi; Fukushima, Makoto; Kihara, Shinji; Libby, Peter; Minami, Shiro (Elsevier BV, 2013)Objective Adiponectin (APN) is an adipocytokine with anti-atherogenic and anti-inflammatory properties. Hypoadiponectinemia may associate with increased risk for coronary artery disease (CAD) and acute coronary syndrome ... -
AGE-BSA decreases ABCG1 expression and reduces macrophage cholesterol efflux to HDL
Isoda, Kikuo; Folco, Eduardo; Shimizu, Koichi; Libby, Peter (Elsevier BV, 2007)Background Previous reports have suggested that advanced glycation end products (AGE) participate in the pathogenesis of diabetic macroangiopathy. However, current understanding of the mechanisms by which AGE may accelerate ... -
Allergic Lung Inflammation Aggravates Angiotensin II–Induced Abdominal Aortic Aneurysms in Mice
Liu, Cong-Lin; Wang, Yi; Liao, Mengyang; Wemmelund, Holger; Ren, Jingyuan; Fernandes, Cleverson; Zhou, Yi; Sukhova, Galina K.; Lindholt, Jes S.; Johnsen, Søren P.; Zhang, Jin-Ying; Cheng, Xiang; Huang, Xiaozhu; Daugherty, Alan; Levy, Bruce David; Libby, Peter; Shi, Guo-Ping (Ovid Technologies (Wolters Kluwer Health), 2015) -
Allergic lung inflammation promotes atherosclerosis in apolipoprotein E-deficient mice
Liu, Cong-Lin; Wang, Yi; Liao, Mengyang; Santos, Marcela Malheiro; Fernandes, Cleverson; Sukhova, Galina K.; Zhang, Jin-Ying; Cheng, Xiang; Yang, Chongzhe; Huang, Xiaozhu; Levy, Bruce David; Libby, Peter; Wu, Gongxiong; Shi, Guo-Ping (Elsevier BV, 2016)Inflammation drives asthma and atherosclerosis. Clinical studies suggest that asthmatic patients have a high risk of atherosclerosis. Yet this hypothesis remains uncertain, given that Th2 imbalance causes asthma whereas ... -
Angiotensin II-induced TLR4 mediated abdominal aortic aneurysm in apolipoprotein E knockout mice is dependent on STAT3
Qin, Zhexue; Bagley, Jessamyn; Sukhova, Galina K.; Baur, Wendy E.; Park, Ho-Jin; Beasley, Debbie; Libby, Peter; Zhang, Yali; Galper, Jonas B. (Elsevier BV, 2015)Abdominal Aortic Aneurysm (AAA) is a major cause of mortality and morbidity in men over 65 years of age. Male apolipoprotein E knockout (ApoE−/−) mice infused with angiotensin II (AngII) develop AAA. Although AngII stimulates ... -
Associations between Soluble CD40 Ligand, Atherosclerosis Risk Factors, and Subclinical Atherosclerosis: Results from the Dallas Heart Study
de Lemos, James A.; Zirlik, Andreas; Schönbeck, Uwe; Varo, Nerea; Murphy, Sabina A.; Khera, Amit Vikram; McGuire, Darren K.; Stanek, Greg; Lo, Hao S.; Nuzzo, Rebecca; Morrow, David Andrew; Peshock, Ronald; Libby, Peter (American Heart Association, 2005)Objectives. The purpose of this study was to evaluate the associations between plasma levels of soluble CD40 ligand (sCD40L), atherosclerosis risk factors, and evidence of subclinical atherosclerosis. Methods and results. ... -
Asthma Associates With Human Abdominal Aortic Aneurysm and RuptureSignificance
Liu, Cong-Lin; Wemmelund, Holger; Wang, Yi; Liao, Mengyang; Lindholt, Jes S.; Johnsen, Søren P.; Vestergaard, Henrik; Fernandes, Cleverson; Sukhova, Galina K.; Cheng, Xiang; Zhang, Jin-Ying; Yang, Chongzhe; Huang, Xiaozhu; Daugherty, Alan; Levy, Bruce David; Libby, Peter; Shi, Guo-Ping (Ovid Technologies (Wolters Kluwer Health), 2016)Objective—Both asthma and abdominal aortic aneurysms (AAA) involve inflammation. It remains unknown whether these diseases interact. Approach and Results—Databases analyzed included Danish National Registry of Patients, ... -
Atherogenesis in Mice Does Not Require CD40 Ligand from Bone Marrow-Derived Cells
Bavendiek, Udo; Zirlik, Andreas; LaClair, Samantha; MacFarlane, Lindsey Adair; Libby, Peter; Schönbeck, Uwe (American Heart Association, 2005)Objective. Recent research suggests a central role for CD40 ligand (CD40L) in atherogenesis. However, the relevant cellular source of this proinflammatory cytokine remains unknown. To test the hypothesis that CD40L expressed ... -
An atherogenic diet rapidly induces VCAM-1, a cytokine-regulatable mononuclear leukocyte adhesion molecule, in rabbit aortic endothelium
Li, H.; Cybulsky, M. I.; Gimbrone, Michael Anthony; Libby, Peter (Ovid Technologies (Wolters Kluwer Health), 1993)Accumulation of monocyte-derived foam cells in focal areas of the arterial intima is a key step in early atherogenesis. We investigated the expression of vascular cell adhesion molecule-1 (VCAM-1), a mononuclear leukocyte ... -
Atheromas that cause fatal thrombosis are usually large and frequently accompanied by vessel enlargement
Bezerra, Hiram Grando; Higuchi, Maria de Lourdes; Gutierrez, Paulo Sampaio; Palomino, Sueli Aparecida; Silvestre, Julia Maria La Chioma; Libby, Peter; Ramires, José Antonio Franchini (Elsevier BV, 2001)Several lines of clinical evidence show that AMI frequently occurs at sites with mild to moderate degree of coronary stenosis. The degree of luminal stenosis depends on plaque deposition and degree of vessel remodeling, ... -
Atherosclerosis: Successes, Surprises, and Future Challenges
Libby, Peter; Bornfeldt, Karin E.; Tall, Alan R. (Ovid Technologies (Wolters Kluwer Health), 2016)This new compendium of 16 articles "reviews the current state-of-the-art of atherosclerosis research spanning from a global health perspective to fundamental molecular mechanisms. The editors intend this collection of ... -
Baseline Characteristics of Participants in the JUPITER Trial, A Randomized Placebo-Controlled Primary Prevention Trial of Statin Therapy Among Individuals With Low Low-Density Lipoprotein Cholesterol and Elevated High-Sensitivity C-Reactive Protein
Ridker, Paul M.; Fonseca, Francisco A.H.; Genest, Jacques; Gotto, Antonio M.; Kastelein, John J.P.; Khurmi, Nardev S.; Koenig, Wolfgang; Libby, Peter; Lorenzatti, Alberto J.; Nordestgaard, Borge G.; Shepherd, James; Willerson, James T.; Glynn, Robert James (Elsevier BV, 2007)The Justification for the Use of statins in Primary prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) is a randomized, double-blind, placebo-controlled primary prevention trial of statin therapy among ... -
Biomarkers: A Challenging Conundrum in Cardiovascular Disease
Libby, Peter; King, Kevin Robert (Ovid Technologies (Wolters Kluwer Health), 2015)The use of biomarkers has proven utility in cardiovascular medicine and holds great promise for future advances, but their application requires considerable rigor in thinking and methodology. Numerous confounding factors ... -
Cathepsin K Deficiency Reduces Elastase Perfusion-Induced Abdominal Aortic Aneurysms in Mice
Sun, Jiusong; Sukhova, Galina K.; Zhang, Jie; Chen, Han; Sjoberg, Sara; Libby, Peter; Xia, Mingcan; Xiong, Na; Gelb, Bruce D.; Shi, Guo-Ping (Ovid Technologies (Wolters Kluwer Health), 2011)Objective: Cathepsin K (CatK) is one of the most potent mammalian elastases. We have previously shown increased expression of CatK in human abdominal aortic aneurysm (AAA) lesions. Whether this protease participates directly ... -
Cathepsin L Activity Is Essential to Elastase Perfusion-Induced Abdominal Aortic Aneurysms in Mice
Sun, Jiusong; Sukhova, Galina K.; Zhang, Jie; Chen, Han; Sjoberg, S.; Libby, Peter; Xiang, M.; Wang, J.; Peters, C.; Reinheckel, T.; Shi, Guo-Ping (Ovid Technologies (Wolters Kluwer Health), 2011)Objective—The development of abdominal aortic aneurysms (AAA) requires extensive aortic wall matrix degradation. Human AAA lesions express high levels of cathepsin L (CatL), one of the most potent mammalian elastases. ... -
Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells
Liu, Jian; Sukhova, Galina K.; Yang, Jin-Tian; Sun, Jiusong; Ma, Likun; Ren, An; Xu, Wei-Hua; Fu, Huanxiang; Dolganov, Gregory M.; Hu, Chengcheng; Libby, Peter; Shi, Guo-Ping (Elsevier BV, 2006)The cysteine protease cathepsin L is one of the most potent mammalian elastases and collagenases, widely expressed at basal levels in most tested tissues and cell types, and regulated by pro-inflammatory stimuli. The ... -
Characterization of smooth muscle-like cells in circulating human peripheral blood
Sugiyama, Seigo; Kugiyama, Kiyotaka; Nakamura, Shinichi; Kataoka, Keiichiro; Aikawa, Masanori; Shimizu, Koichi; Koide, Shunichi; Mitchell, Richard Neal; Ogawa, Hisao; Libby, Peter (Elsevier BV, 2006)Smooth muscle cells play an important role in human vascular diseases. Several lines of evidence demonstrate that circulating smooth muscle precursor cells contribute to intimal hyperplasia in animal models. We obtained ... -
Chlamydial and human heat shock protein 60s activate human vascular endothelium, smooth muscle cells, and macrophages
Kol, Amir; Bourcier, Todd; Lichtman, Andrew Harry; Libby, Peter (American Society for Clinical Investigation, 1999)Both chlamydial and human heat shock protein 60s (HSP 60), which colocalize in human atheroma, may contribute to inflammation during atherogenesis. We tested the hypothesis that chlamydial or human HSP 60 activates human ...