Browsing by Author "Pagano, Marcello"
Now showing items 1-20 of 24
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Assessing Biases in the Evaluation of Classification Assays for HIV Infection Recency
Patterson-Lomba, Oscar; Wu, Julia W.; Pagano, Marcello (Public Library of Science, 2015)Identifying recent HIV infection cases has important public health and clinical implications. It is essential for estimating incidence rates to monitor epidemic trends and evaluate the effectiveness of interventions. ... -
Bayes-LQAS: Classifying the Prevalence of Global Acute Malnutrition
Olives, Casey; Pagano, Marcello (BioMed Central, 2010)Lot Quality Assurance Sampling (LQAS) applications in health have generally relied on frequentist interpretations for statistical validity. Yet health professionals often seek statements about the probability distribution ... -
Choosing a Cluster Sampling Design for Lot Quality Assurance Sampling Surveys
Hund, Lauren; Bedrick, Edward J.; Pagano, Marcello (Public Library of Science, 2015)Lot quality assurance sampling (LQAS) surveys are commonly used for monitoring and evaluation in resource-limited settings. Recently several methods have been proposed to combine LQAS with cluster sampling for more timely ... -
Correlates of Total Physical Activity among Middle-Aged and Elderly Women
Orsini, Nicola; Bellocco, Rino; Bottai, Matteo; Pagano, Marcello; Wolk, Alicja (BioMed Central, 2007)Information on correlates of total physical activity (PA) levels among middle-aged and elderly women is limited. This article aims to investigate whether total daily PA levels are associated with age, body mass index, ... -
Determining the dynamics of influenza transmission by age
White, Laura F; Archer, Brett; Pagano, Marcello (BioMed Central, 2014)Background: It is widely accepted that influenza transmission dynamics vary by age; however methods to quantify the reproductive number by age group are limited. We introduce a simple method to estimate the reproductive ... -
Disease Mapping with Spatially Uncertain Data
Manjourides, Justin; Cohen, Ted; Jeffery, Caroline; Pagano, Marcello (University of Illinois at Chicago Library, 2013)Objective: Uncertainty regarding the location of disease acquisition, as well as selective identification of cases, may bias maps of risk. We propose an extension to a distance-based mapping method (DBM) that incorporates ... -
The effect of clustering on lot quality assurance sampling: a probabilistic model to calculate sample sizes for quality assessments
Hedt-Gauthier, Bethany L; Mitsunaga, Tisha; Hund, Lauren; Olives, Casey; Pagano, Marcello (BioMed Central, 2013)Background: Traditional Lot Quality Assurance Sampling (LQAS) designs assume observations are collected using simple random sampling. Alternatively, randomly sampling clusters of observations and then individuals within ... -
The effect of spatial aggregation on performance when mapping a risk of disease
Jeffery, Caroline; Ozonoff, Al; Pagano, Marcello (BioMed Central, 2014)Background: Spatial data on cases are available either in point form (e.g. longitude/latitude), or aggregated by an administrative region (e.g. zip code or census tract). Statistical methods for spatial data may accommodate ... -
Effect of spatial resolution on cluster detection: a simulation study
Ozonoff, Al; Jeffery, Caroline; Manjourides, Justin Daniel; White, Laura Forsberg; Pagano, Marcello (BioMed Central, 2007)Background: Aggregation of spatial data is intended to protect privacy, but some effects of aggregation on spatial methods have not yet been quantified. Methods: We generated 3,000 spatial data sets and evaluated power of ... -
Estimating HIV prevalence from surveys with low individual consent rates: annealing individual and pooled samples
Hund, Lauren; Pagano, Marcello (BioMed Central, 2013)Many HIV prevalence surveys are plagued by the problem that a sizeable number of surveyed individuals do not consent to contribute blood samples for testing. One can ignore this problem, as is often done, but the resultant ... -
Estimating the reproductive number in the presence of spatial heterogeneity of transmission patterns
White, Laura F; Archer, Brett; Pagano, Marcello (BioMed Central, 2013)Background: Estimates of parameters for disease transmission in large-scale infectious disease outbreaks are often obtained to represent large groups of people, providing an average over a potentially very diverse area. ... -
Estimation of the reproductive number and the serial interval in early phase of the 2009 influenza A/H1N1 pandemic in the USA
White, Laura Forsberg; Wallinga, Jacco; Finelli, Lyn; Reed, Carrie; Riley, Steven; Lipsitch, Marc; Pagano, Marcello (Wiley-Blackwell, 2009)BACKGROUND: The United States was the second country to have a major outbreak of novel influenza A/H1N1 in what has become a new pandemic. Appropriate public health responses to this pandemic depend in part on early ... -
Evaluation of high-dose rifampin in patients with new, smear-positive tuberculosis (HIRIF): study protocol for a randomized controlled trial
Milstein, Meredith; Lecca, Leonid; Peloquin, Charles; Mitchison, Denis; Seung, Kwonjune; Pagano, Marcello; Coleman, David; Osso, Elna; Coit, Julia; Vargas Vasquez, Dante Elmo; Sanchez Garavito, Epifanio; Calderon, Roger; Contreras, Carmen; Davies, Geraint; Mitnick, Carole D. (BioMed Central, 2016)Background: Evidence has existed for decades that higher doses of rifampin may be more effective, but potentially more toxic, than standard doses used in tuberculosis treatment. Whether increased doses of rifampin could ... -
Improving data quality and supervision of antiretroviral therapy sites in Malawi: an application of Lot Quality Assurance Sampling
Hedt-Gauthier, Bethany L; Tenthani, Lyson; Mitchell, Shira Arkin; Chimbwandira, Frank M; Makombe, Simon; Chirwa, Zengani; Schouten, Erik J; Pagano, Marcello; Jahn, Andreas (BioMed Central, 2012)Background: High quality program data is critical for managing, monitoring, and evaluating national HIV treatment programs. By 2009, the Malawi Ministry of Health had initiated more than 270,000 patients on HIV treatment ... -
‘Location, Location, Location’: a spatial approach for rare variant analysis and an application to a study on non-syndromic cleft lip with or without cleft palate
Fier, Heide; Won, Sungho; Prokopenko, Dmitry; AlChawa, Taofik; Ludwig, Kerstin U.; Fimmers, Rolf; Silverman, Edwin K.; Pagano, Marcello; Mangold, Elisabeth; Lange, Christoph (Oxford University Press, 2012)Motivation: For the analysis of rare variants in sequence data, numerous approaches have been suggested. Fixed and flexible threshold approaches collapse the rare variant information of a genomic region into a test statistic ... -
Multidrug-resistant tuberculosis treatment failure detection depends on monitoring interval and microbiological method
Mitnick, Carole D.; White, Richard A.; Lu, Chunling; Rodriguez, Carly A.; Bayona, Jaime; Becerra, Mercedes C.; Burgos, Marcos; Centis, Rosella; Cohen, Theodore; Cox, Helen; D'Ambrosio, Lia; Danilovitz, Manfred; Falzon, Dennis; Gelmanova, Irina Y.; Gler, Maria T.; Grinsdale, Jennifer A.; Holtz, Timothy H.; Keshavjee, Salmaan; Leimane, Vaira; Menzies, Dick; Migliori, Giovanni Battista; Milstein, Meredith B.; Mishustin, Sergey P.; Pagano, Marcello; Quelapio, Maria I.; Shean, Karen; Shin, Sonya S.; Tolman, Arielle W.; van der Walt, Martha L.; Van Deun, Armand; Viiklepp, Piret (European Respiratory Society, 2016)Debate persists about monitoring method (culture or smear) and interval (monthly or less frequently) during treatment for multidrug-resistant tuberculosis (MDR-TB). We analysed existing data and estimated the effect of ... -
Multiple Category-Lot Quality Assurance Sampling: A New Classification System with Application to Schistosomiasis Control
Olives, Casey; Valadez, Joseph J.; Brooker, Simon J.; Pagano, Marcello (Public Library of Science, 2012)Background: Originally a binary classifier, Lot Quality Assurance Sampling (LQAS) has proven to be a useful tool for classification of the prevalence of Schistosoma mansoni into multiple categories (≤10%, >10 and <50%, ... -
A Novel Approach to Evaluating the Iron and Folate Status of Women of Reproductive Age in Uzbekistan after 3 Years of Flour Fortification with Micronutrients
Hund, Lauren; Northrop-Clewes, Christine A.; Nazario, Ronald; Suleymanova, Dilora; Mirzoyan, Lusine; Irisova, Munira; Pagano, Marcello; Valadez, Joseph J. (Public Library of Science, 2013)Background: The Uzbekistan 1996 Demographic Health Survey reported 60.4% of women of reproductive age (WRA) had low hemoglobin concentrations (<120 g/L), and anemia was an important public health problem. Fortification of ... -
Novel Developmental Analyses Identify Longitudinal Patterns of Early Gut Microbiota that Affect Infant Growth
White, Richard A.; Bjørnholt, Jørgen V.; Baird, Donna D.; Midtvedt, Tore; Harris, Jennifer R.; Pagano, Marcello; Hide, Winston; Rudi, Knut; Moen, Birgitte; Iszatt, Nina; Peddada, Shyamal D.; Eggesbø, Merete (Public Library of Science, 2013)It is acknowledged that some obesity trajectories are set early in life, and that rapid weight gain in infancy is a risk factor for later development of obesity. Identifying modifiable factors associated with early rapid ... -
Novel Statistical Methods Applied in Clinical Trials and Gut Microbiota
White, Richard (2012-10-23)Ethical clinical trials need both societal and personal equipoise. Recently, personal equipoise has been disturbed by the introduction of interim analyses; after an interim analysis has been performed the study administrators ...