Now showing items 1-20 of 37

    • Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release 

      Ilyinskii, Petr O.; Roy, Christopher J.; O’Neil, Conlin P.; Browning, Erica A.; Pittet, Lynnelle A.; Altreuter, David H.; Alexis, Frank; Tonti, Elena; Shi, Jinjun; Basto, Pamela A.; Iannacone, Matteo; Radovic-Moreno, Aleksandar F.; Langer, Robert S.; Farokhzad, Omid Cameron; von Andrian, Ulrich H.; Johnston, Lloyd P.M.; Kishimoto, Takashi Kei (Elsevier BV, 2014)
      Augmentation of immunogenicity can be achieved by particulate delivery of an antigen and by its co-administration with an adjuvant. However, many adjuvants initiate strong systemic inflammatory reactions in vivo, leading ...
    • Biosensor Platforms for Molecular Analyses of Circulating Cancer Biomarkers 

      Shao, Huilin (2013-10-15)
      Solid cancers often shed (sub)cellular materials into the circulation, such as circulating tumor cells and extracellular microvesicles. Mounting evidence supports that these circulating materials could serve as surrogate ...
    • ChemoRad nanoparticles: a novel multifunctional nanoparticle platform for targeted delivery of concurrent chemoradiation 

      Wang, Andrew Z; Yuet, Kai; Zhang, Liangfang; Gu, Frank X; Huynh-Le, Minh; Radovic-Moreno, Aleksandar F; Kantoff, Philip Wayne; Bander, Neil H; Langer, Robert S.; Farokhzad, Omid Cameron (Future Medicine Ltd, 2010)
      Aim: The development of chemoradiation – the concurrent administration of chemotherapy and radiotherapy – has led to significant improvements in local tumor control and survival. However, it is limited by its high toxicity. ...
    • A defined synthetic substrate for serum-free culture of human stem cell derived cardiomyocytes with improved functional maturity identified using combinatorial materials microarrays 

      Patel, Asha K.; Celiz, Adam D.; Rajamohan, Divya; Anderson, Daniel G.; Langer, Robert; Davies, Martyn C.; Alexander, Morgan R.; Denning, Chris (2016)
      Cardiomyocytes from human stem cells have applications in regenerative medicine and can provide models for heart disease and toxicity screening. Soluble components of the culture system such as growth factors within serum ...
    • The development of bioresorbable composite polymeric implants with high mechanical strength 

      Sharma, Upma; Concagh, Danny; Core, Lee; Kuang, Yina; You, Changcheng; Pham, Quynh; Zugates, Greg; Busold, Rany; Webber, Stephanie; Merlo, Jonathan; Langer, Robert S.; Whitesides, George McClelland; Palasis, Maria (Springer Nature, 2017)
    • Drug delivery systems in urology—getting “smarter” 

      Farokhzad, Omid Cameron; Dimitrakov, Jordan D.; Karp, Jeffrey MIchael; Khademhosseini, Ali; Freeman, Michael; Langer, Robert S. (Elsevier BV, 2006)
      Urology holds the most enviable position in the medical firmament. Unique among specialties in bringing the surgeon in contact with humans throughout the spectrum of human life—from newborn to geriatric patients—urologists ...
    • Effects of ligands with different water solubilities on self-assembly and properties of targeted nanoparticles 

      Valencia, Pedro M.; Hanewich-Hollatz, Mikhail H.; Gao, Weiwei; Karim, Fawziya; Langer, Robert S.; Karnik, Rohit; Farokhzad, Omid Cameron (Elsevier BV, 2011)
      The engineering of drug-encapsulated targeted nanoparticles (NPs) has the potential to revolutionize drug therapy. A major challenge for the smooth translation of targeted NPs to the clinic has been developing methods for ...
    • Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling 

      Sahay, Gaurav; Querbes, William; Alabi, Christopher; Eltoukhy, Ahmed; Sarkar, Sovan; Zurenko, Christopher; Karagiannis, Emannouil; Love, Kevin; Chen, Delai; Zoncu, Roberto; Buganim, Yosef; Schroeder, Avi; Langer, Robert; Anderson, Daniel G. (2013)
      Despite substantial efforts to understand the interactions between nanoparticles and cells, the cellular processes that determine the efficiency of intracellular drug delivery remain largely unclear. Here we examined ...
    • Emerging nanotechnology approaches for HIV/AIDS treatment and prevention 

      Mamo, Tewodros; Moseman, E Ashley; Kolishetti, Nagesh; Salvador-Morales, Carolina; Shi, Jinjun; Kuritzkes, Daniel Robert; Langer, Robert S.; Andrian, Ulrich von; Farokhzad, Omid Cameron (Future Medicine Ltd, 2010)
      Currently, there is no cure and no preventive vaccine for HIV/AIDS. Combination antiretroviral therapy has dramatically improved treatment, but it has to be taken for a lifetime, has major side effects and is ineffective ...
    • Engineering of lipid-coated PLGA nanoparticles with a tunable payload of diagnostically active nanocrystals for medical imaging 

      Mieszawska, Aneta J.; Gianella, Anita; Cormode, David P.; Zhao, Yiming; Meijerink, Andries; Langer, Robert S.; Farokhzad, Omid Cameron; Fayad, Zahi A.; Mulder, Willem J. M. (Royal Society of Chemistry (RSC), 2012)
      Polylactic-co-glycolic acid (PLGA) based nanoparticles are biocompatible and biodegradable and therefore have been extensively investigated as therapeutic carriers. Here, we engineered diagnostically active PLGA nanoparticles ...
    • Formulation of functionalized PLGA–PEG nanoparticles for in vivo targeted drug delivery 

      Cheng, Jianjun; Teply, Benjamin; Sherifi, Ines; Sung, Josephine; Luther, Gaurav; Gu, Frank; Levy-Nissenbaum, Etgar; Rodovic-Moreno, Aleksandar; Langer, Robert S.; Farokhzad, Omid Cameron (Elsevier BV, 2007)
      Nanoparticle (NP) size has been shown to significantly effect the biodistribution of targeted and non-targeted NPs in an organ specific manner. Herein we have developed NPs from carboxy-terminated poly (d,l-lactide-co-gl ...
    • Formulation/Preparation of Functionalized Nanoparticles for In Vivo Targeted Drug Delivery 

      Gu, Frank; Langer, Robert S.; Farokhzad, Omid Cameron (Springer Science + Business Media, 2009)
      Targeted cancer therapy allows the delivery of therapeutic agents to cancer cells without incurring undesirable side effects on the neighboring healthy tissues. Over the past decade, there has been an increasing interest ...
    • Functional Multipotency of Stem Cells: A Conceptual Review of Neurotrophic Factor-Based Evidence and Its Role in Translational Research 

      Kabatas, Serdar; Wakeman, Dustin R; Wang, Junmei; Snyder, Evan Y; Teng, Yang D.; Yu, Dou; Ropper, Alexander Eli; Li, Jianxue; Sullivan, Maryrose P.; Redmond, D. Eugene; Langer, Robert S.; Sidman, Richard Leon (Bentham Science Publishers, 2011)
      We here propose an updated concept of stem cells (SCs), with an emphasis on neural stem cells (NSCs). The conventional view, which has touched principally on the essential property of lineage multipotency (e.g., the ability ...
    • Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron–sulfur deficiency and pulmonary hypertension 

      White, Kevin; Lu, Yu; Annis, Sofia; Hale, Andrew E; Chau, B Nelson; Dahlman, James E; Hemann, Craig; Opotowsky, Alexander R; Vargas, Sara O; Rosas, Ivan; Perrella, Mark A; Osorio, Juan C; Haley, Kathleen J; Graham, Brian B; Kumar, Rahul; Saggar, Rajan; Saggar, Rajeev; Wallace, W Dean; Ross, David J; Khan, Omar F; Bader, Andrew; Gochuico, Bernadette R; Matar, Majed; Polach, Kevin; Johannessen, Nicolai M; Prosser, Haydn M; Anderson, Daniel G; Langer, Robert; Zweier, Jay L; Bindoff, Laurence A; Systrom, David; Waxman, Aaron B; Jin, Richard C; Chan, Stephen Y (BlackWell Publishing Ltd, 2015)
      Iron–sulfur (Fe-S) clusters are essential for mitochondrial metabolism, but their regulation in pulmonary hypertension (PH) remains enigmatic. We demonstrate that alterations of the miR-210-ISCU1/2 axis cause Fe-S deficiencies ...
    • Immunocompatibility properties of lipid–polymer hybrid nanoparticles with heterogeneous surface functional groups 

      Salvador-Morales, Carolina; Zhang, Liangfang; Langer, Robert S.; Farokhzad, Omid Cameron (Elsevier BV, 2009)
      Here we report the immunological characterization of lipid-polymer hybrid nanoparticles (NPs) and propose a method to control the levels of complement activation induced by these NPs. This method consists of the highly ...
    • Macroporous Nanowire Nanoelectronic Scaffolds for Synthetic Tissues 

      Tian, Bozhi; Liu, Jia; Dvir, Tal; Jin, Lihua; Tsui, Jonathan H.; Qing, Quan; Suo, Zhigang; Langer, Robert S.; Kohane, Daniel Solomon; Lieber, Charles M. (Nature Publishing Group, 2012)
      The development of three-dimensional (3D) synthetic biomaterials as structural and bioactive scaffolds is central to fields ranging from cellular biophysics to regenerative medicine. As of yet, these scaffolds cannot ...
    • Microfluidic technologies for accelerating the clinical translation of nanoparticles 

      Valencia, Pedro M.; Farokhzad, Omid Cameron; Karnik, Rohit; Langer, Robert S. (Springer Nature, 2012)
      Using nanoparticles for therapy and imaging holds tremendous promise for the treatment of major diseases such as cancer. However, their translation into the clinic has been slow because it remains difficult to produce ...
    • Molecularly Self-Assembled Nucleic Acid Nanoparticles for Targeted In Vivo siRNA Delivery 

      Lee, Hyukjin; Lytton-Jean, Abigail K. R.; Chen, Yi; Love, Kevin T.; Park, Angela I.; Karagiannis, Emmanouil D.; Sehgal, Alfica; Querbes, William; Zurenko, Christopher S.; Jayaraman, Muthusamy; Peng, Chang G.; Charisse, Klaus; Borodovsky, Anna; Manoharan, Muthiah; Donahoe, Jessica S.; Truelove, Jessica; Nahrendorf, Matthias; Langer, Robert; Anderson, Daniel G. (2013)
      Nanoparticles are employed for delivering therapeutics into cells1,2. However, size, shape, surface chemistry and the presentation of targeting ligands on the surface of nanoparticles can affect circulation half-life and ...
    • A mucosal vaccine against Chlamydia trachomatis generates two waves of protective memory T cells 

      Stary, G; Olive, A; Radovic-Moreno, A. F.; Gondek, D.; Alvarez, David; Basto, P. A.; Perro, M.; Vrbanac, V. D.; Tager, Andrew Martin; Shi, Jinjun; Yethon, J. A.; Farokhzad, Omid Cameron; Langer, Robert S.; Starnbach, Michael N.; von Andrian, Ulrich H. (American Association for the Advancement of Science (AAAS), 2015)
      Genital Chlamydia trachomatis (Ct) infection induces protective immunity that depends on interferon-γ producing CD4 T-cells. By contrast, mucosal exposure to ultraviolet light (UV)-inactivated Ct (UV-Ct) generated regulatory ...
    • Nanoparticles with photoinduced precipitation for the extraction of pollutants from water and soil 

      Brandl, Ferdinand; Bertrand, Nicolas; Lima, Eliana Martins; Langer, Robert (Nature Pub. Group, 2015)
      Nanotechnology may offer fast and effective solutions for environmental clean-up. Herein, amphiphilic diblock copolymers are used to develop a platform of photosensitive core-shell nanoparticles. Irradiation with ultraviolet ...