Browsing by Author "Langer, Robert"

Now showing items 1-20 of 48

    • Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release 

      Ilyinskii, Petr O.; Roy, Christopher J.; O’Neil, Conlin P.; Browning, Erica A.; Pittet, Lynnelle A.; Altreuter, David H.; Alexis, Frank; Tonti, Elena; Shi, Jinjun; Basto, Pamela A.; Iannacone, Matteo; Radovic-Moreno, Aleksandar F.; Langer, Robert S.; Farokhzad, Omid Cameron; von Andrian, Ulrich H.; Johnston, Lloyd P.M.; Kishimoto, Takashi Kei (Elsevier BV, 2014)
      Augmentation of immunogenicity can be achieved by particulate delivery of an antigen and by its co-administration with an adjuvant. However, many adjuvants initiate strong systemic inflammatory reactions in vivo, leading ...

    • Biosensor Platforms for Molecular Analyses of Circulating Cancer Biomarkers 

      Shao, Huilin (2013-10-15)
      Solid cancers often shed (sub)cellular materials into the circulation, such as circulating tumor cells and extracellular microvesicles. Mounting evidence supports that these circulating materials could serve as surrogate ...

    • Blood, Guts, and Hope 

      Schoellhammer, Carl; Langer, Robert S.; Traverso, Carlo Giovanni (Sigma Xi, 2017)
      Treatment of gastrointestinal tissue with ultrasound makes it more permeable to medications that can alleviate inflammatory bowel disease.

    • ChemoRad nanoparticles: a novel multifunctional nanoparticle platform for targeted delivery of concurrent chemoradiation 

      Wang, Andrew Z; Yuet, Kai; Zhang, Liangfang; Gu, Frank X; Huynh-Le, Minh; Radovic-Moreno, Aleksandar F; Kantoff, Philip Wayne; Bander, Neil H; Langer, Robert S.; Farokhzad, Omid Cameron (Future Medicine Ltd, 2010)
      Aim: The development of chemoradiation – the concurrent administration of chemotherapy and radiotherapy – has led to significant improvements in local tumor control and survival. However, it is limited by its high toxicity. ...

    • A defined synthetic substrate for serum-free culture of human stem cell derived cardiomyocytes with improved functional maturity identified using combinatorial materials microarrays 

      Patel, Asha K.; Celiz, Adam D.; Rajamohan, Divya; Anderson, Daniel G.; Langer, Robert; Davies, Martyn C.; Alexander, Morgan R.; Denning, Chris (2016)
      Cardiomyocytes from human stem cells have applications in regenerative medicine and can provide models for heart disease and toxicity screening. Soluble components of the culture system such as growth factors within serum ...

    • The development of bioresorbable composite polymeric implants with high mechanical strength 

      Sharma, Upma; Concagh, Danny; Core, Lee; Kuang, Yina; You, Changcheng; Pham, Quynh; Zugates, Greg; Busold, Rany; Webber, Stephanie; Merlo, Jonathan; Langer, Robert S.; Whitesides, George McClelland; Palasis, Maria (Springer Nature, 2017)

    • Drug delivery systems in urology—getting “smarter” 

      Farokhzad, Omid Cameron; Dimitrakov, Jordan D.; Karp, Jeffrey MIchael; Khademhosseini, Ali; Freeman, Michael; Langer, Robert S. (Elsevier BV, 2006)
      Urology holds the most enviable position in the medical firmament. Unique among specialties in bringing the surgeon in contact with humans throughout the spectrum of human life—from newborn to geriatric patients—urologists ...

    • Effects of ligands with different water solubilities on self-assembly and properties of targeted nanoparticles 

      Valencia, Pedro M.; Hanewich-Hollatz, Mikhail H.; Gao, Weiwei; Karim, Fawziya; Langer, Robert S.; Karnik, Rohit; Farokhzad, Omid Cameron (Elsevier BV, 2011)
      The engineering of drug-encapsulated targeted nanoparticles (NPs) has the potential to revolutionize drug therapy. A major challenge for the smooth translation of targeted NPs to the clinic has been developing methods for ...

    • Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling 

      Sahay, Gaurav; Querbes, William; Alabi, Christopher; Eltoukhy, Ahmed; Sarkar, Sovan; Zurenko, Christopher; Karagiannis, Emannouil; Love, Kevin; Chen, Delai; Zoncu, Roberto; Buganim, Yosef; Schroeder, Avi; Langer, Robert; Anderson, Daniel G. (2013)
      Despite substantial efforts to understand the interactions between nanoparticles and cells, the cellular processes that determine the efficiency of intracellular drug delivery remain largely unclear. Here we examined ...

    • An elastic second skin 

      Yu, Betty; Kang, Soo-Young; Akthakul, Ariya; Ramadurai, Nithin; Pilkenton, Morgan; Patel, Alpesh; Nashat, Amir; Anderson, Daniel Griffith; Sakamoto, Fernanda; Gilchrest, Barbara Ann; Anderson, Richard Rox; Langer, Robert S. (Springer Nature, 2016)
      We report the synthesis and application of an elastic, wearable crosslinked polymer layer (XPL) that mimics the properties of normal, youthful skin. XPL is made of a tunable polysiloxane-based material that can be engineered ...

    • Emerging nanotechnology approaches for HIV/AIDS treatment and prevention 

      Mamo, Tewodros; Moseman, E Ashley; Kolishetti, Nagesh; Salvador-Morales, Carolina; Shi, Jinjun; Kuritzkes, Daniel Robert; Langer, Robert S.; Andrian, Ulrich von; Farokhzad, Omid Cameron (Future Medicine Ltd, 2010)
      Currently, there is no cure and no preventive vaccine for HIV/AIDS. Combination antiretroviral therapy has dramatically improved treatment, but it has to be taken for a lifetime, has major side effects and is ineffective ...

    • Engineering of lipid-coated PLGA nanoparticles with a tunable payload of diagnostically active nanocrystals for medical imaging 

      Mieszawska, Aneta J.; Gianella, Anita; Cormode, David P.; Zhao, Yiming; Meijerink, Andries; Langer, Robert S.; Farokhzad, Omid Cameron; Fayad, Zahi A.; Mulder, Willem J. M. (Royal Society of Chemistry (RSC), 2012)
      Polylactic-co-glycolic acid (PLGA) based nanoparticles are biocompatible and biodegradable and therefore have been extensively investigated as therapeutic carriers. Here, we engineered diagnostically active PLGA nanoparticles ...

    • Engineering precision 

      Traverso, G.; Langer, Robert S. (American Association for the Advancement of Science (AAAS), 2015-05-27)
      <jats:p>Engineering sciences will play a vital role in delivering precision medicine to the bedside.</jats:p>

    • Formulation of functionalized PLGA–PEG nanoparticles for in vivo targeted drug delivery 

      Cheng, Jianjun; Teply, Benjamin; Sherifi, Ines; Sung, Josephine; Luther, Gaurav; Gu, Frank; Levy-Nissenbaum, Etgar; Rodovic-Moreno, Aleksandar; Langer, Robert S.; Farokhzad, Omid Cameron (Elsevier BV, 2007)
      Nanoparticle (NP) size has been shown to significantly effect the biodistribution of targeted and non-targeted NPs in an organ specific manner. Herein we have developed NPs from carboxy-terminated poly (d,l-lactide-co-gl ...

    • Formulation/Preparation of Functionalized Nanoparticles for In Vivo Targeted Drug Delivery 

      Gu, Frank; Langer, Robert S.; Farokhzad, Omid Cameron (Springer Science + Business Media, 2009)
      Targeted cancer therapy allows the delivery of therapeutic agents to cancer cells without incurring undesirable side effects on the neighboring healthy tissues. Over the past decade, there has been an increasing interest ...

    • Functional Multipotency of Stem Cells: A Conceptual Review of Neurotrophic Factor-Based Evidence and Its Role in Translational Research 

      Kabatas, Serdar; Wakeman, Dustin R; Wang, Junmei; Snyder, Evan Y; Teng, Yang D.; Yu, Dou; Ropper, Alexander Eli; Li, Jianxue; Sullivan, Maryrose P.; Redmond, D. Eugene; Langer, Robert S.; Sidman, Richard Leon (Bentham Science Publishers, 2011)
      We here propose an updated concept of stem cells (SCs), with an emphasis on neural stem cells (NSCs). The conventional view, which has touched principally on the essential property of lineage multipotency (e.g., the ability ...

    • Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron–sulfur deficiency and pulmonary hypertension 

      White, Kevin; Lu, Yu; Annis, Sofia; Hale, Andrew E; Chau, B Nelson; Dahlman, James E; Hemann, Craig; Opotowsky, Alexander R; Vargas, Sara O; Rosas, Ivan; Perrella, Mark A; Osorio, Juan C; Haley, Kathleen J; Graham, Brian B; Kumar, Rahul; Saggar, Rajan; Saggar, Rajeev; Wallace, W Dean; Ross, David J; Khan, Omar F; Bader, Andrew; Gochuico, Bernadette R; Matar, Majed; Polach, Kevin; Johannessen, Nicolai M; Prosser, Haydn M; Anderson, Daniel G; Langer, Robert; Zweier, Jay L; Bindoff, Laurence A; Systrom, David; Waxman, Aaron B; Jin, Richard C; Chan, Stephen Y (BlackWell Publishing Ltd, 2015)
      Iron–sulfur (Fe-S) clusters are essential for mitochondrial metabolism, but their regulation in pulmonary hypertension (PH) remains enigmatic. We demonstrate that alterations of the miR-210-ISCU1/2 axis cause Fe-S deficiencies ...

    • Immunocompatibility properties of lipid–polymer hybrid nanoparticles with heterogeneous surface functional groups 

      Salvador-Morales, Carolina; Zhang, Liangfang; Langer, Robert S.; Farokhzad, Omid Cameron (Elsevier BV, 2009)
      Here we report the immunological characterization of lipid-polymer hybrid nanoparticles (NPs) and propose a method to control the levels of complement activation induced by these NPs. This method consists of the highly ...

    • An inflammation-targeting hydrogel for local drug delivery in inflammatory bowel disease 

      Zhang, Sufeng; Ermann, Joerg; Succi, Marc; Zhou, Allen; Hamilton, Matthew; Cao, Bonnie; Korzenik, Joshua; Glickman, Jonathan; Vemula, Praveen K.; Glimcher, Laurie; Traverso, Giovanni; Langer, Robert; Karp, Jeffrey (American Association for the Advancement of Science (AAAS), 2015-08-12)
      A hydrogel binds to inflamed tissues, delivering therapeutics locally and reducing systemic drug exposure in mouse models of inflammatory bowel disease.

    • Long-Term Implant Fibrosis Prevention in Rodents and Non-Human Primates Using Localized Deliverable Crystals 

      Farah, Shady; Doloff, Joshua; Han, Hye Jung; Olafson, Katy; McAvoy, Malia; Graham, Adam; Langer, Robert; Anderson, Daniel; Sadraei, Atieh; Vyas, Keval; Tam, Hok Hei; Holliser-Locke, Jennifer; Kowalski, Piotr; Griffin, Marissa; Ashley, Meng; McGarrigle, James; Oberholzer, Jose; Weir, Gordon; Greiner, Dale (Nature Publishing Group, 2019-06-24)
      Implantable medical devices have revolutionized modern medicine. However, immune-mediated foreign body response (FBR) to the materials of these devices can limit their function or even induce failure. Here we describe ...