Now showing items 1-9 of 9

    • Addendum guidelines for the prevention of peanut allergy in the United States: report of the National Institute of Allergy and Infectious Diseases-sponsored expert panel 

      Togias, Alkis; Cooper, Susan F.; Acebal, Maria L.; Assa’ad, Amal; Baker, James R.; Beck, Lisa A.; Block, Julie; Byrd-Bredbenner, Carol; Chan, Edmond S.; Eichenfield, Lawrence F.; Fleischer, David M.; Fuchs, George J.; Furuta, Glenn T.; Greenhawt, Matthew J.; Gupta, Ruchi S.; Habich, Michele; Jones, Stacie M.; Keaton, Kari; Muraro, Antonella; Plaut, Marshall; Rosenwasser, Lanny J.; Rotrosen, Daniel; Sampson, Hugh A.; Schneider, Lynda C.; Sicherer, Scott H.; Sidbury, Robert; Spergel, Jonathan; Stukus, David R.; Venter, Carina; Boyce, Joshua A. (BioMed Central, 2017)
      Background: Food allergy is an important public health problem because it affects children and adults, can be severe and even life-threatening, and may be increasing in prevalence. Beginning in 2008, the National Institute ...
    • Addendum guidelines for the prevention of peanut allergy in the United States: Report of the National Institute of Allergy and Infectious Diseases–sponsored expert panel 

      Togias, Alkis; Cooper, Susan F.; Acebal, Maria L.; Assa’ad, Amal; Baker, James R.; Beck, Lisa A.; Block, Julie; Byrd-Bredbenner, Carol; Chan, Edmond S.; Eichenfield, Lawrence F.; Fleischer, David M.; Fuchs, George J.; Furuta, Glenn T.; Greenhawt, Matthew J.; Gupta, Ruchi S.; Habich, Michele; Jones, Stacie M.; Keaton, Kari; Muraro, Antonella; Plaut, Marshall; Rosenwasser, Lanny J.; Rotrosen, Daniel; Sampson, Hugh A.; Schneider, Lynda C.; Sicherer, Scott H.; Sidbury, Robert; Spergel, Jonathan; Stukus, David R.; Venter, Carina; Boyce, Joshua A. (BioMed Central, 2017)
      Background: Food allergy is an important public health problem because it affects children and adults, can be severe and even life-threatening, and may be increasing in prevalence. Beginning in 2008, the National Institute ...
    • Cysteinyl Leukotrienes and Their Receptors; Emerging Concepts 

      Kanaoka, Yoshihide; Boyce, Joshua A. (The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease, 2014)
      Cysteinyl leukotrienes (cys-LTs) are potent mediators of inflammation derived from arachidonic acid through the 5-lipoxygenase/leukotriene C4 synthase pathway. The derivation of their chemical structures and identification ...
    • Differential Regulation of Cysteinyl Leukotriene Receptor Signaling by Protein Kinase C in Human Mast Cells 

      Kondeti, Vinay; Duah, Ernest; Al-Azzam, Nosayba; Thodeti, Charles K.; Boyce, Joshua A.; Paruchuri, Sailaja (Public Library of Science, 2013)
      Cysteinyl leukotrienes (cys-LTs) are a group of lipid mediators that are potent bronchoconstrictors, powerful inducers of vascular leakage and potentiators of airway hyperresponsiveness. Cys-LTs play an essential role in ...
    • Fas-Activated Serine/Threonine Phosphoprotein Promotes Immune-Mediated Pulmonary Inflammation 

      Simarro, Maria; Giannattasio, Giorgio; De la Fuente, Miguel A.; Benarafa, Charaf; Subramanian, Kulandayan K.; Ishizawar, Rumey Chang; Balestrieri, Barbara; Andersson, Emma M.; Luo, Hongbo; Orduna, Antonio; Boyce, Joshua A.; Anderson, Paul Joseph (The American Association of Immunologists, 2010)
      We generated Fas-activated serine threonine phosphoprotein (FAST)-deficient mice \((FAST^{−/−})\) to study the in vivo role of FAST in immune system function. In a model of house dust mite-induced allergic pulmonary ...
    • Gene-by-environment effect of house dust mite on purinergic receptor P2Y12 (P2RY12) and lung function in children with asthma 

      Bunyavanich, S.; Boyce, Joshua A.; Raby, Benjamin Alexander; Weiss, Scott Tillman (Wiley-Blackwell, 2011)
      Background— Distinct receptors likely exist for leukotriene(LT)E4, a potent mediator of airway inflammation. Purinergic receptor P2Y12 is needed for LTE4-induced airways inflammation, and P2Y12 antagonism attenuates house ...
    • Impact of botanical oils on polyunsaturated fatty acid metabolism and leukotriene generation in mild asthmatics 

      Arm, Jonathan P; Boyce, Joshua A; Wang, Lin; Chhay, Heng; Zahid, Muhammad; Patil, Vaishali; Govindarajulu, Usha; Ivester, Priscilla; Weaver, Kelly L; Sergeant, Susan; Israel, Elliot; Chilton, Floyd H (BioMed Central, 2013)
      Background: Dietary supplementation with botanical oils that contain n-6 and n-3 eighteen carbon chain (18C)-PUFA such as γ linolenic acid (GLA, 18:3n-6), stearidonic acid (SDA, 18:4n-3) and α linolenic acid (ALA, 18:3n-3) ...
    • LPA5 Is Abundantly Expressed by Human Mast Cells and Important for Lysophosphatidic Acid Induced MIP-1β Release 

      Lundequist, Anders; Boyce, Joshua A. (Public Library of Science, 2011)
      Background: Lysophosphatidic acid (LPA) is a bioactive lipid inducing proliferation, differentiation as well as cytokine release by mast cells through G-protein coupled receptors. Recently GPR92/LPA5 was identified as an ...
    • LTC4 synthase polymorphism modifies efficacy of botanical seed oil combination in asthma 

      Kazani, Shamsah; Arm, Jonathan P; Boyce, Joshua; Chhay, Heng; Dutile, Stefanie; Wechsler, Michael E; Govindarajulu, Usha; Ivester, Priscilla; Ainsworth, Hannah C; Sergeant, Susan; Chilton, Floyd H; Israel, Elliot (Springer International Publishing, 2014)
      Botanical seed oils reduce the generation of leukotrienes in patients with asthma. Our objective was to determine the efficacy of a botanical seed oil combination against airflow obstruction in asthma, and to determine the ...