Now showing items 1-2 of 2

    • Large-scale preparation of fluorescence multiplex host cell reactivation (FM-HCR) reporters 

      Piett, C. G.; Pecen, T. J.; Laverty, D. J.; Nagel, Zachary (Springer Science and Business Media LLC, 2021-08-06)
      Repair of DNA damage is a critical survival mechanism that impacts susceptibility to a variety of human diseases and represents a key target for cancer therapy. A major barrier to applying this knowledge in research and ...
    • WRN Helicase is a Synthetic Lethal Target in Microsatellite Unstable Cancers 

      Bass, Adam; Chan, Edmond; Shibue, Tsukasa; McFarland, James; Gaeta, Benjamin; Ghandi, Mahmoud; Dumont, Nancy; Gonzalez, Alfredo; McPartlan, Justine; Li, Tianxia; Zhang, Yanxi; Liu, Jie Bin; Lazaro, Jean-Bernard; Gu, Peili; Piett, Cortt; Apffel, Annie; Ali, Syed Omar; Deasy, Rebecca; Keskula, Paula; Ng, Raymond; Roberts, Emma; Reznichenko, Elizaveta; Leung, Lisa; Alimova, Maria; Schenone, Monica; Islam, Manirul; Maruvka, Yosef; Liu, Yang; Roper, Jatin; Raghavan, Srivatsan; Giannakis, Marios; Tseng, Yuen-Yi; Nagel, Zachary; D’Andrea, Alan; Root, David; Boehm, Jesse; Getz, Gad; Chang, Sandy; Golub, Todd; Tsherniak, Aviad; Vazquez, Francisca (Cold Spring Harbor Laboratory, 2018-12-21)
      Synthetic lethality, an interaction whereby the co-occurrence of two genetic events leads to cell death but one event alone does not, can be exploited for cancer therapeutics1. DNA repair processes represent attractive ...