Now showing items 1-20 of 20

    • Activated Human CD4+CD45RO+ Memory T-Cells Indirectly Inhibit NLRP3 Inflammasome Activation through Downregulation of P2X7R Signalling 

      Beynon, Vanessa; Quintana, Francisco Javier; Weiner, Howard Lee (Public Library of Science, 2012)
      Inflammasomes are multi-protein complexes that control the production of pro-inflammatory cytokines such as IL-1β. Inflammasomes play an important role in the control of immunity to tumors and infections, and also in ...
    • Adaptive Autoimmunity and Foxp3-Based Immunoregulation in Zebrafish 

      Quintana, Francisco Javier; Iglesias, Antonio H.; Farez, Mauricio F.; Caccamo, Mario; Burns, Evan J.; Kassam, Nasim; Oukka, Mohamed; Weiner, Howard Lee (Public Library of Science, 2010)
      Background: Jawed vertebrates generate their immune-receptor repertoire by a recombinatorial mechanism that has the potential to produce harmful autoreactive lymphocytes. In mammals, peripheral tolerance to self-antigens ...
    • Alterations of the human gut microbiome in multiple sclerosis 

      Jangi, Sushrut; Gandhi, Roopali; Cox, Laura M.; Li, Ning; von Glehn, Felipe; Yan, Raymond; Patel, Bonny; Mazzola, Maria Antonietta; Liu, Shirong; Glanz, Bonnie L.; Cook, Sandra; Tankou, Stephanie; Stuart, Fiona; Melo, Kirsy; Nejad, Parham; Smith, Kathleen; Topçuolu, Begüm D.; Holden, James; Kivisäkk, Pia; Chitnis, Tanuja; De Jager, Philip L.; Quintana, Francisco J.; Gerber, Georg K.; Bry, Lynn; Weiner, Howard L. (Nature Publishing Group, 2016)
      The gut microbiome plays an important role in immune function and has been implicated in several autoimmune disorders. Here we use 16S rRNA sequencing to investigate the gut microbiome in subjects with multiple sclerosis ...
    • Characterization of Human CD39+ Th17 Cells with Suppressor Activity and Modulation in Inflammatory Bowel Disease 

      Longhi, Maria Serena; Moss, Alan; Bai, Aiping; Wu, Yan; Huang, Huang; Cheifetz, Adam; Quintana, Francisco J.; Robson, Simon C. (Public Library of Science, 2014)
      Induced regulatory T-cells (iT-reg) and T helper type 17 (Th17) in the mouse share common CD4 progenitor cells and exhibit overlapping phenotypic and functional features. Here, we show that human Th17 cells endowed with ...
    • HSP60 as a Target of Anti-Ergotypic Regulatory T Cells 

      Quintana, Francisco Javier; Mimran, Avishai; Carmi, Pnina; Mor, Felix; Cohen, Irun R. (Public Library of Science, 2008)
      The 60 kDa heat shock protein (HSP60) has been reported to influence T-cell responses in two ways: as a ligand of toll-like receptor 2 signalling and as an antigen. Here we describe a new mechanism of T-cell immuno-regulation ...
    • IL-10-dependent Tr1 cells attenuate astrocyte activation and ameliorate chronic central nervous system inflammation 

      Mayo, Lior; Cunha, Andre Pires Da; Madi, Asaf; Beynon, Vanessa; Yang, Zhiping; Alvarez, Jorge I.; Prat, Alexandre; Sobel, Raymond A.; Kobzik, Lester; Lassmann, Hans; Quintana, Francisco J.; Weiner, Howard L. (Oxford University Press, 2016)
      See Winger and Zamvil (doi:10.1093/brain/aww121) for a scientific commentary on this article. The innate immune system plays a central role in the chronic central nervous system inflammation that drives neurological ...
    • IL-21 induces IL-22 production in CD4+ T-cells 

      Yeste, Ada; Mascanfroni, Ivan D.; Nadeau, Meghan; Burns, Evan J.; Tukpah, Ann-Marcia; Santiago, Andrezza; Wu, Chuan; Patel, Bonny; Kumar, Deepak; Quintana, Francisco J. (2014)
      IL-22 produced by innate lymphoid cells (ILCs) and CD4+ T cells plays an important role in host defense and mucosal homeostasis, thus it is important to investigate the mechanisms that regulate IL-22 production. We ...
    • Immunological Relevance of the Coevolution of IDO1 and AHR 

      Jaronen, Merja; Quintana, Francisco J. (Frontiers Media S.A., 2014)
      The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor initially identified because of its role in controlling the cellular response to environmental molecules. More recently, AHR has been shown to ...
    • Induction and molecular signature of pathogenic TH17 cells 

      Lee, Youjin; Awasthi, Amit; Yosef, Nir; Quintana, Francisco Javier; Xiao, Sheng; Peters, Anneli; Wu, Chuan; Kleinewietfeld, Markus; Kunder, Sharon R.; Hafler, David A.; Sobel, Raymond A.; Regev, Aviv; Kuchroo, Vijay Kumar (2012)
      Interleukin 17 (IL-17)-producing TH17 cells are often present at the sites of tissue inflammation in autoimmune diseases, which has lead to the conclusion that TH17 are main drivers of autoimmune tissue injury. However, ...
    • Induction of IgG3 to LPS via Toll-Like Receptor 4 Co-Stimulation 

      Quintana, Francisco Javier; Solomon, Aderet; Cohen, Irun R.; Nussbaum, Gabriel (Public Library of Science, 2008)
      B-cells integrate antigen-specific signals transduced via the B-cell receptor (BCR) and antigen non-specific co-stimulatory signals provided by cytokines and CD40 ligation in order to produce IgG antibodies. Toll-like ...
    • Loss of the Lupus Autoantigen Ro52/Trim21 Induces Tissue Inflammation and Systemic Autoimmunity by Disregulating the IL-23–Th17 Pathway 

      Espinosa, Alexander; Dardalhon, Valerie; Brauner, Susanna; Ambrosi, Aurelie; Higgs, Rowan; Sjöstrand, Maria; Eloranta, Maija-Leena; Ní Gabhann, Joan; Winqvist, Ola; Sundelin, Birgitta; Jefferies, Caroline A.; Rozell, Björn; Wahren-Herlenius, Marie; Quintana, Francisco Javier; Kuchroo, Vijay Kumar (The Rockefeller University Press, 2009)
      Ro52/Trim21 is targeted as an autoantigen in systemic lupus erythematosus and Sjögren's syndrome. Polymorphisms in the Ro52 gene have been linked to these autoimmune conditions, but the molecular mechanism by which Ro52 ...
    • Network Theory Analysis of Antibody-Antigen Reactivity Data: The Immune Trees at Birth and Adulthood 

      Madi, Asaf; Kenett, Dror Y.; Bransburg-Zabary, Sharron; Merbl, Yifat Haya; Quintana, Francisco Javier; Tauber, Alfred I.; Cohen, Irun R.; Ben-Jacob, Eshel (Public Library of Science, 2011)
      Motivation: New antigen microarray technology enables parallel recording of antibody reactivities with hundreds of antigens. Such data affords system level analysis of the immune system’s organization using methods and ...
    • Precision Medicine in Multiple Sclerosis: Future of PET Imaging of Inflammation and Reactive Astrocytes 

      Poutiainen, Pekka; Jaronen, Merja; Quintana, Francisco J.; Brownell, Anna-Liisa (Frontiers Media S.A., 2016)
      Non-invasive molecular imaging techniques can enhance diagnosis to achieve successful treatment, as well as reveal underlying pathogenic mechanisms in disorders such as multiple sclerosis (MS). The cooperation of advanced ...
    • Purinergic Signaling as a Regulator of Th17 Cell Plasticity 

      Fernández, Dominique; Flores-Santibáñez, Felipe; Neira, Jocelyn; Osorio-Barrios, Francisco; Tejón, Gabriela; Nuñez, Sarah; Hidalgo, Yessia; Fuenzalida, Maria Jose; Meza, Daniel; Ureta, Gonzalo; Lladser, Alvaro; Pacheco, Rodrigo; Acuña-Castillo, Claudio; Guixé, Victoria; Quintana, Francisco J.; Bono, Maria Rosa; Rosemblatt, Mario; Sauma, Daniela (Public Library of Science, 2016)
      T helper type 17 (Th17) lymphocytes, characterized by the production of interleukin-17 and other pro-inflammatory cytokines, are present in intestinal lamina propria and have been described as important players driving ...
    • Quantitative MRI study of Pineal Gland in MS. 

      Egorova, Svetlana; Denes, Palma; Polgar-Turcsanyi, Mariann; Anderson, Mark Allen; Cavallari, Michele; Guttmann, Charles R.G.; Glanz, Bonnie; Chitnis, Tanuja; Bove, Riley; Buckle, Guy; De Jager, Philip Lawrence; Severson, Cristopher; Stankiewicz, James; Houtchens, Maria K.; Quintana, Francisco Javier; Gandhi, Roopali; Webb, Pia; Meier, Dominik; Healy, Brian Curran; Weiner, Howard Lee (2016)
    • Serum lipid antibodies are associated with cerebral tissue damage in multiple sclerosis 

      Bakshi, Rohit; Yeste, A; Patel, B.; Tauhid, Shahamat Syed; Tummala, Subhash; Rahbari, R.; Chu, Renxin; Regev, Keren; Kivisakk, Pia; Weiner, Howard Lee; Quintana, Francisco Javier (Ovid Technologies (Wolters Kluwer Health), 2016)
      Objective: To determine whether peripheral immune responses as measured by serum antigen arrays are linked to cerebral MRI measures of disease severity in multiple sclerosis (MS). Methods: In this cross-sectional study, ...
    • Systems biology approaches for the study of multiple sclerosis 

      Quintana, Francisco J; Farez, Mauricio F; Weiner, Howard L (Blackwell Publishing Ltd, 2008)
      Multiple sclerosis (MS) is a progressive neurological disease caused by an autoimmune attack to the central nervous system (CNS). MS is thought to result from a complex interaction between genetic and environmental factors. ...
    • A Systems Immunology Approach to the Host-Tumor Interaction: Large-Scale Patterns of Natural Autoantibodies Distinguish Healthy and Tumor-Bearing Mice 

      Merbl, Yifat Haya; Itzchak, Royi; Vider-Shalit, Tal; Louzoun, Yoram; Quintana, Francisco Javier; Vadai, Ezra; Eisenbach, Lea; Cohen, Irun R. (Public Library of Science, 2009)
      Traditionally, immunology has considered a meaningful antibody response to be marked by large amounts of high-affinity antibodies reactive with the specific inciting antigen; the detection of small amounts of low-affinity ...
    • Toll-like receptor stimulation differentially regulates vasoactive intestinal peptide type 2 receptor in macrophages 

      Herrera, Juan Luis; Gonzalez-Rey, Elena; Fernandez-Montesinos, Rafael; Quintana, Francisco J; Najmanovich, Rafael; Pozo, David (John Wiley & Sons, Ltd, 2009)
      Vasoactive intestinal peptide (VIP) was originally isolated as a vasodilator intestinal peptide, then as a neuropeptide. In the immune system, VIP is described as an endogenous macrophage-deactivating factor. VIP exerts ...
    • Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and CNS inflammation via the aryl hydrocarbon receptor 

      Rothhammer, Veit; Mascanfroni, Ivan D.; Bunse, Lukas; Takenaka, Maisa C.; Kenison, Jessica E.; Mayo, Lior; Chao, Chun-Cheih; Patel, Bonny; Yan, Raymond; Blain, Manon; Alvarez, Jorge I.; Kébir, Hania; Anandasabapathy, Niroshana; Izquierdo, Guillermo; Jung, Steffen; Obholzer, Nikolaus; Pochet, Nathalie; Clish, Clary B.; Prinz, Marco; Prat, Alexandre; Antel, Jack; Quintana, Francisco J. (2016)
      Astrocytes play important roles in the central nervous system (CNS) during health and disease. Through genome-wide analyses we detected a transcriptional response to type I interferons (IFN-I) in astrocytes during experimental ...