Browsing by Author "Van tyne, Daria"

Now showing items 1-11 of 11

    • Changes in drug sensitivity and anti-malarial drug resistance mutations over time among Plasmodium falciparum parasites in Senegal 

      Van Tyne, Daria; Dieye, Baba; Valim, Clarissa; Daniels, Rachel F; Sène, Papa Diogoye; Lukens, Amanda K; Ndiaye, Mouhamadou; Bei, Amy K; Ndiaye, Yaye Die; Hamilton, Elizabeth J; Ndir, Omar; Mboup, Souleymane; Volkman, Sarah K; Wirth, Dyann F; Ndiaye, Daouda (BioMed Central, 2013)
      Background: Malaria treatment efforts are hindered by the rapid emergence and spread of drug resistant parasites. Simple assays to monitor parasite drug response in direct patient samples (ex vivo) can detect drug resistance ...

    • Dual defensin strategy for targeting Enterococcus faecalis 

      Gilmore, Michael S.; Lebreton, Francois Herve; Van tyne, Daria Natalie (Proceedings of the National Academy of Sciences, 2013)

    • Enrichment of Reticulocytes from Whole Blood using Aqueous Multiphase Systems of Polymers 

      Kumar, Ashok Ashwin; Lim, Caeul; Moreno, Yovany; Mace, Charles R.; Syed, Abeer; Van Tyne, Daria Natalie; Wirth, Dyann F.; Duraisingh, Manoj T.; Whitesides, George McClelland (Wiley-Blackwell, 2014)
      This paper demonstrates the enrichment of reticulocytes by centrifuging whole blood through aqueous multiphase systems (AMPSs)—immiscible phases of solutions of polymers that form step-gradients in density. The interfaces ...

    • Genetic Surveillance Detects Both Clonal and Epidemic Transmission of Malaria following Enhanced Intervention in Senegal 

      Daniels, Rachel Fath; Chang, Hsiao-Han; Séne, Papa Diogoye; Park, Danny C.; Neafsey, Daniel Edward; Schaffner, Stephen; Hamilton, Elizabeth Julia; Lukens, Amanda Kathleen; Van Tyne, Daria Natalie; Mboup, Souleymane; Sabeti, Pardis Christine; Ndiaye, Daouda; Wirth, Dyann Fergus; Hartl, Daniel L.; Cooke, Sarah Volkman (Public Library of Science, 2013)
      Using parasite genotyping tools, we screened patients with mild uncomplicated malaria seeking treatment at a clinic in Thiès, Senegal, from 2006 to 2011. We identified a growing frequency of infections caused by genetically ...

    • A Global Transcriptional Analysis of Plasmodium Falciparum Malaria Reveals A Novel Family of Telomere-Associated lncRNAs 

      Broadbent, Kate Mariel; Park, Daniel John; Wolf, Ashley Robin; Van Tyne, Daria Natalie; Sims, Jennifer Sung; Ribacke, Ulf Erik; Cooke, Sarah Volkman; Duraisingh, Manoj T.; Wirth, Dyann Fergus; Sabeti, Pardis Christine; Rinn, John L (BioMed Central, 2011)
      Background: Mounting evidence suggests a major role for epigenetic feedback in Plasmodium falciparum transcriptional regulation. Long non-coding RNAs (lncRNAs) have recently emerged as a new paradigm in epigenetic ...

    • Identification and Characterization of Novel Drug Resistance Loci in Plasmodium falciparum 

      Van Tyne, Daria Natalie (2013-03-15)
      Malaria has plagued mankind for millennia. Antimalarial drug use over the last century has generated highly drug-resistant parasites, which amplify the burden of this disease and pose a serious obstacle to control efforts. ...

    • Identification and Functional Validation of the Novel Antimalarial Resistance Locus PF10_0355 in Plasmodium falciparum 

      Van Tyne, Daria Natalie; Park, Daniel John; Schaffner, Stephen; Neafsey, Daniel Edward; Angelino, Elaine Lee; Cortese, Joseph F.; Barnes, Kayla G.; Rosen, David M.; Lukens, Amanda Kathleen; Daniels, Rachel Fath; Milner, Danny Arnold; Johnson, Charles A.; Shlyakhter, Ilya; Grossman, Sharon Rachel; Becker, Justin S.; Yamins, Daniel Louis Kanef; Karlsson, Elinor Kathryn; Ndiaye, Daouda; Sarr, Ousmane; Mboup, Souleymane; Happi, Christian Tientcha; Furlotte, Nicholas A.; Eskin, Eleazar; Kang, Hyun Min; Hartl, Daniel L.; Birren, Bruce W.; Wiegand, Roger C.; Lander, Eric Steven; Wirth, Dyann Fergus; Cooke, Sarah Volkman; Sabeti, Pardis Christine (Public Library of Science, 2011)
      The Plasmodium falciparum parasite's ability to adapt to environmental pressures, such as the human immune system and antimalarial drugs, makes malaria an enduring burden to public health. Understanding the genetic basis ...

    • Live Imaging of Mitosomes and Hydrogenosomes by HaloTag Technology 

      Martincová, Eva; Voleman, Luboš; Najdrová, Vladimíra; De Napoli, Maximiliano; Eshar, Shiri; Gualdron, Melisa; Hopp, Christine S.; Sanin, David E.; Tembo, Dumizulu L.; Walker, Dawn; Marcinčiková, Michaela; Tachezy, Jan; Doležal, Pavel; Van Tyne, Daria Natalie (Public Library of Science, 2012)
      Hydrogenosomes and mitosomes represent remarkable mitochondrial adaptations in the anaerobic parasitic protists such as Trichomonas vaginalis and Giardia intestinalis, respectively. In order to provide a tool to study these ...

    • Sequence-Based Association and Selection Scans Identify Drug Resistance Loci in the Plasmodium Falciparum Malaria Parasite 

      Park, Daniel John; Lukens, Amanda Kathleen; Neafsey, Daniel Edward; Schaffner, Stephen; Chang, Hsiao-Han; Valim, Clarissa; Ribacke, Ulf Erik; Van Tyne, Daria Natalie; Galinsky, Kevin Joseph; Galligan, Meghan; Becker, Justin S.; Ndiaye, Daouda; Mboup, Souleymane; Wiegand, Roger C.; Hartl, Daniel L.; Sabeti, Pardis Christine; Wirth, Dyann F.; Cooke, Sarah K. (Proceedings of the National Academy of Sciences, 2012)
      Through rapid genetic adaptation and natural selection, the Plasmodium falciparum parasite—the deadliest of those that cause malaria—is able to develop resistance to antimalarial drugs, thwarting present efforts to control ...

    • SNP Genotyping Identifies New Signatures of Selection in a Deep Sample of West African Plasmodium falciparum Malaria Parasites 

      Amambua-Ngwa, Alfred; Barnes, Kayla G.; Sene, Papa; Conway, David J.; Park, Daniel John; Volkman, Sarah; Bei, Amy Kristine; Lukens, Amanda Kathleen; Van Tyne, Daria Natalie; Ndiaye, Daouda; Wirth, Dyann Fergus; Neafsey, Daniel Edward; Schaffner, Stephen (Oxford University Press, 2012)
      We used a high-density single-nucleotide polymorphism array to genotype 75 Plasmodium falciparum isolates recently collected from Senegal and The Gambia to search for signals of selection in this malaria endemic region. ...

    • Structure, Function, and Biology of the Enterococcus faecalis Cytolysin 

      Van Tyne, Daria; Martin, Melissa J.; Gilmore, Michael S. (MDPI, 2013)
      Enterococcus faecalis is a Gram-positive commensal member of the gut microbiota of a wide range of organisms. With the advent of antibiotic therapy, it has emerged as a multidrug resistant, hospital-acquired pathogen. ...