Browsing by Author "Ye, Li"
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Identification of TRPV4 as a Regulator of Adipose Oxidative Metabolism, Inflammation and Energy Homeostasis by a Chemical Biology Approach
Ye, Li (2013-02-25)\(PGC1\alpha\) is a key transcriptional coregulator of mitochondrial biogenesis, oxidative metabolism and thermogenesis. We developed a quantitative high throughput screen to identify small molecules that can induce ... -
A PGC1-\(\alpha\)-dependent Myokine that Drives Brown-fat-like Development of White Fat and Thermogenesis
Boström, Pontus; Wu, Jun; Jedrychowski, Mark P.; Korde, Anisha; Ye, Li; Lo, James C; Rasbach, Kyle A.; Boström, Elisabeth Almer; Choi, Jang Hyun; Long, Jonathan Zhong; Kajimura, Shingo; Zingaretti, Maria Cristina; Vind, Birgitte F.; Tu, Hua; Cinti, Saverio; Højlund, Kurt; Gygi, Steven P.; Spiegelman, Bruce Michael (Nature Publishing Group, 2012)Exercise benefits a variety of organ systems in mammals, and some of the best-recognized effects of exercise on muscle are mediated by the transcriptional co-activator PPAR-γ co-activator-1 α (PGC1-α). Here we show in mouse ...