Browsing by Author "DePinho, Ronald A."

Now showing items 1-10 of 10

    • The Differentiation and Stress Response Factor XBP-1 Drives Multiple Myeloma Pathogenesis 

      Carrasco, Daniel R.; Sukhdeo, Kumar; Protopopova, Marina; Enos, Miriam; Zheng, Mei; Mani, Mala; Ivanova, Elena V.; Tonon, Giovanni; Sinha, Raktim; Carrasco, Daniel E.; Henderson, Joel Michael; Pinkus, Geraldine Sowinski; Munshi, Nikhil C; Horner, James W.; Protopopov, Alexei; Anderson, Kenneth Carl; DePinho, Ronald A. (Cell Press, 2007)
      Multiple myeloma (MM) evolves from a highly prevalent premalignant condition termed MGUS. The factors underlying the malignant transformation of MGUS are unknown. We report a MGUS/MM phenotype in transgenic mice with ...

    • Forkhead Transcription Factors (FoxOs) Promote Apoptosis of Insulin-Resistant Macrophages During Cholesterol-Induced Endoplasmic Reticulum Stress 

      Senokuchi, Takafumi; Liang, Chien-Ping; Seimon, Tracie A.; Han, Seongah; Matsumoto, Michihiro; Accili, Domenico; Tabas, Ira; Tall, Alan R.; Banks, Alexander; Paik, Ji-Hye; DePinho, Ronald A. (American Diabetes Association, 2008)
      OBJECTIVE—Endoplasmic reticulum stress increases macrophage apoptosis, contributing to the complications of atherosclerosis. Insulin-resistant macrophages are more susceptible to endoplasmic reticulum stress–associated ...

    • Foxo1 Links Hyperglycemia to LDL Oxidation and Endothelial Nitric Oxide Synthase Dysfunction in Vascular Endothelial Cells 

      Tanaka, Jun; Qiang, Li; Banks, Alexander; Welch, Carrie L.; Matsumoto, Michihiro; Kitamura, Tadahiro; Ido-Kitamura, Yukari; DePinho, Ronald A.; Accili, Domenico (American Diabetes Association, 2009)
      OBJECTIVE: Atherosclerotic cardiovascular disease is the leading cause of death among people with diabetes. Generation of oxidized LDLs and reduced nitric oxide (NO) availability because of endothelial NO synthase (eNOS) ...

    • Impact papers on aging in 2009 

      Blagosklonny, Mikhail V.; Campisi, Judy; Bartke, Andrzej; Blasco, Maria A.; Bonner, William M.; Bohr, Vilhelm A.; Jr, Robert M. Brosh; Brunet, Anne; Donehower, Lawrence A.; Finch, Caleb E.; Finkel, Toren; Gorospe, Myriam; Gudkov, Andrei V.; Hall, Michael N.; Hekimi, Siegfried; Helfand, Stephen L.; Karlseder, Jan; Kenyon, Cynthia; Kroemer, Guido; Longo, Valter; Nussenzweig, Andre; Osiewacz, Heinz D.; Peeper, Daniel S.; Rando, Thomas A.; Rudolph, K Lenhard; Sassone-Corsi, Paolo; Serrano, Manuel; Sharpless, Norman E.; Skulachev, Vladimir P.; Tower, John; Verdin, Eric; Vijg, Jan; Sinclair, David Andrew; DePinho, Ronald A.; Tilly, Jonathan Lee (Impact Journals LLC, 2010)
      The editorial board of Aging reviews research papers published in 2009, which they believe have or will have a significant impact on aging research. Among many others, the topics include genes that accelerate aging or in ...

    • A Mouse Plasma Peptide Atlas as a Resource for Disease Proteomics 

      Menon, Rajasree; Deutsch, Eric W; Pitteri, Sharon J; Faca, Vitor M; Newcomb, Lisa F; Bardeesy, Nabeel; Hung, Kenneth E; Jacks, Tyler; Politi, Katerina; Aebersold, Ruedi; Omenn, Gilbert S; States, David J; Hanash, Samir M; Zhang, Qing; Wang, Hong; DePinho, Ronald A.; Dinulescu, Daniela M; Kucherlapati, Raju (BioMed Central, 2008)
      We present an in-depth analysis of mouse plasma leading to the development of a publicly available repository composed of 568 liquid chromatography-tandem mass spectrometry runs. A total of 13,779 distinct peptides have ...

    • A Mouse to Human Search for Plasma Proteome Changes Associated with Pancreatic Tumor Development 

      Faca, Vitor M; Song, Kenneth S; Krasnoselsky, Alexei L; Newcomb, Lisa F; Plentz, Ruben R; Redston, Mark S; Pitteri, Sharon J; Pereira-Faca, Sandra R; Ireton, Renee C; Katayama, Hiroyuki; Glukhova, Veronika; Phanstiel, Douglas; Brenner, Dean E; Anderson, Michelle A; Misek, David; Scholler, Nathalie; Urban, Nicole D; Barnett, Matt J; Edelstein, Cim; Goodman, Gary E; Thornquist, Mark D; McIntosh, Martin W; Bardeesy, Nabeel; Hanash, Samir M; Wang, Hong; Zhang, Qing; Gurumurthy, Sushma; DePinho, Ronald A. (Public Library of Science, 2008)
      Background: The complexity and heterogeneity of the human plasma proteome have presented significant challenges in the identification of protein changes associated with tumor development. Refined genetically engineered ...

    • Somatic p16INK4a Loss Accelerates Melanomagenesis 

      Monahan, K B; Rozenberg, G I; Krishnamurthy, J; Johnson, S M; Liu, W; Bradford, M K; Horner, James W.; DePinho, Ronald A.; Sharpless, N E (Nature Publishing Group, 2010)
      Loss of p16\(^{INK4a}–RB\) and ARF–p53 tumor suppressor pathways, as well as activation of RAS–RAF signaling, is seen in a majority of human melanomas. Although heterozygous germline mutations of p16\(^{INK4a}\) are ...

    • Targeted Nanoparticles for Imaging Incipient Pancreatic Ductal Adenocarcinoma 

      Kelly, Kimberly A.; Bardeesy, Nabeel; Anbazhagan, Rajesh; Gurumurthy, Sushma; Berger, Justin; Alencar, Herlen; DePinho, Ronald A.; Mahmood, Umar; Weissleder, Ralph (Public Library of Science, 2008)
      Background: Pancreatic ductal adenocarcinoma (PDAC) carries an extremely poor prognosis, typically presenting with metastasis at the time of diagnosis and exhibiting profound resistance to existing therapies. The development ...

    • Targeting EGFR Induced Oxidative Stress by PARP1 Inhibition in Glioblastoma Therapy 

      Nitta, Masayuki; Stommel, Jayne; Ng, Kimberly; Kesari, Santosh; Furnari, Frank; Hoadley, Katherine A.; Cavenee, Webster K.; Kozono, David Eiichi; Kennedy, Richard; Zinn, Pascal Olivier; Kushwaha, Deepa S; Chin, Lynda; DePinho, Ronald A.; D'Andrea, Alan David; Chen, Clark Chin-Chung (Public Library of Science, 2010)
      Despite the critical role of Epidermal Growth Factor Receptor (EGFR) in glioblastoma pathogenesis [1], [2], EGFR targeted therapies have achieved limited clinical efficacy [3]. Here we propose an alternate therapeutic ...

    • Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells 

      Harada, Yohsuke; Harada, Yasuyo; Elly, Chris; Ying, Ge; Paik, Ji-Hye; Liu, Yun-Cai; DePinho, Ronald A. (The Rockefeller University Press, 2010)
      The transcription factor Foxp3 is essential for optimal regulatory T (T reg) cell development and function. Here, we show that CD4+ T cells from Cbl-b RING finger mutant knockin or Cbl-b–deficient mice show impaired ...