Now showing items 1-6 of 6

    • Brown Fat and Browning for the Treatment of Obesity and Related Metabolic Disorders 

      Kim, So Hun; Plutzky, Jorge (Korean Diabetes Association, 2016)
      Brown fat is a specialized fat depot that can increase energy expenditure and produce heat. After the recent discovery of the presence of active brown fat in human adults and novel transcription factors controlling brown ...
    • Deficiency of Retinaldehyde Dehydrogenase 1 Induces BMP2 and Increases Bone Mass In Vivo 

      Nallamshetty, Shriram; Wang, Hong; Rhee, Eun-Jung; Kiefer, Florian W.; Brown, Jonathan D.; Lotinun, Sutada; Le, Phuong; Baron, Roland; Rosen, Clifford J.; Plutzky, Jorge (Public Library of Science, 2013)
      The effects of retinoids, the structural derivatives of vitamin A (retinol), on post-natal peak bone density acquisition and skeletal remodeling are complex and compartment specific. Emerging data indicates that retinoids, ...
    • A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid utilization 

      Liu, Sihao; Brown, Jonathan D.; Stanya, Kristopher J.; Homan, Edwin; Leidl, Mathias; Inouye, Karen; Bhargava, Prerna; Gangl, Matthew R.; Dai, Lingling; Hatano, Ben; Hotamisligil, Gökhan S.; Saghatelian, Alan; Plutzky, Jorge; Lee, Chih-Hao (2014)
      Food intake increases the activity of hepatic de novo lipogenesis, which mediates the conversion of glucose to fats for storage or utilization. In mice, this program follows a circadian rhythm that peaks with nocturnal ...
    • Drivers of the Sex Disparity in Statin Therapy in Patients with Coronary Artery Disease: A Cohort Study 

      Zhang, Huabing; Plutzky, Jorge; Shubina, Maria; Turchin, Alexander (Public Library of Science, 2016)
      Background: Women are less likely to be prescribed statins than men. Existing reports explain only a fraction of this difference. We conducted a study to identify factors that account for sex differences in statin therapy ...
    • Residual macrovascular risk in 2013: what have we learned? 

      Fruchart, Jean-Charles; Davignon, Jean; Hermans, Michel P; Al-Rubeaan, Khalid; Amarenco, Pierre; Assmann, Gerd; Barter, Philip; Betteridge, John; Bruckert, Eric; Cuevas, Ada; Farnier, Michel; Ferrannini, Ele; Fioretto, Paola; Genest, Jacques; Ginsberg, Henry N; Gotto, Antonio M; Hu, Dayi; Kadowaki, Takashi; Kodama, Tatsuhiko; Krempf, Michel; Matsuzawa, Yuji; Núñez-Cortés, Jesús Millán; Monfil, Carlos Calvo; Ogawa, Hisao; Plutzky, Jorge; Rader, Daniel J; Sadikot, Shaukat; Santos, Raul D; Shlyakhto, Evgeny; Sritara, Piyamitr; Sy, Rody; Tall, Alan; Tan, Chee Eng; Tokgözoğlu, Lale; Toth, Peter P; Valensi, Paul; Wanner, Christoph; Zambon, Alberto; Zhu, Junren; Zimmet, Paul (BioMed Central, 2014)
      Cardiovascular disease poses a major challenge for the 21st century, exacerbated by the pandemics of obesity, metabolic syndrome and type 2 diabetes. While best standards of care, including high-dose statins, can ameliorate ...
    • Retinoid Metabolism and Diabetes Mellitus 

      Rhee, Eun-Jung; Plutzky, Jorge (Korean Diabetes Association, 2012)
      Retinoid acid is a metabolite of vitamin A and functions as an important factor in cell survival, differentiation and death. Most previous studies on retinoid metabolism have focused on its association with cancer, hematologic ...