Browsing by Author "Solomon, Keith R."

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    • DIAPH3 Governs the Cellular Transition to the Amoeboid Tumour Phenotype 

      Hager, Martin H; Morley, Samantha; Bielenberg, Diane R; Gao, Sizhen; Morello, Matteo; Holcomb, Ilona N; Liu, Wennuan; Mouneimne, Ghassan; Demichelis, Francesca; Kim, Jayoung; Solomon, Keith R; Adam, Rosalyn M; Isaacs, William B; Higgs, Henry N; Vessella, Robert L; Di Vizio, Dolores; Freeman, Michael R (WILEY-VCH Verlag, 2012)
      Therapies for most malignancies are generally ineffective once metastasis occurs. While tumour cells migrate through tissues using diverse strategies, the signalling networks controlling such behaviours in human tumours ...

    • Impact of Circulating Cholesterol Levels on Growth and Intratumoral Androgen Concentration of Prostate Tumors 

      Mostaghel, Elahe A.; Solomon, Keith R.; Pelton, Kristine; Freeman, Michael R.; Montgomery, R. Bruce (Public Library of Science, 2012)
      Prostate cancer (PCa) is the second most common cancer in men. Androgen deprivation therapy (ADT) leads to tumor involution and reduction of tumor burden. However, tumors eventually reemerge that have overcome the absence ...

    • The Response of the Prostate to Circulating Cholesterol: Activating Transcription Factor 3 (ATF3) as a Prominent Node in a Cholesterol-Sensing Network 

      Vizio, Dolores Di; Kim, Taek-Kyun; Kim, Jonghwan; Pelton, Kristine; Clinton, Steven K.; Hai, Tsonwin; Hwang, Daehee; Kim, Jayoung; Kim, Minjung; Solomon, Keith R.; Freeman, Michael R. (Public Library of Science, 2012)
      Elevated circulating cholesterol is a systemic risk factor for cardiovascular disease and metabolic syndrome, however the manner in which the normal prostate responds to variations in cholesterol levels is poorly understood. ...