Now showing items 1-3 of 3

    • Isogenic Human Pluripotent Stem Cell Models of Cardiovascular Disease-Associated Genetic Variation 

      Peters, Derek Tilghman (2016-03-30)
      A complex interplay of genetic and environmental factors underlies the development of common human diseases such as cardiovascular disease. Despite widespread use of existing medications, coronary heart disease (CHD), ...
    • Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids 

      Freedman, Benjamin S.; Brooks, Craig R.; Lam, Albert Q.; Fu, Hongxia; Morizane, Ryuji; Agrawal, Vishesh; Saad, Abdelaziz F.; Li, Michelle K.; Hughes, Michael R.; Werff, Ryan Vander; Peters, Derek T.; Lu, Junjie; Baccei, Anna; Siedlecki, Andrew M.; Valerius, M. Todd; Musunuru, Kiran; McNagny, Kelly M.; Steinman, Theodore I.; Zhou, Jing; Lerou, Paul H.; Bonventre, Joseph V. (Nature Pub. Group, 2015)
      Human-pluripotent-stem-cell-derived kidney cells (hPSC-KCs) have important potential for disease modelling and regeneration. Whether the hPSC-KCs can reconstitute tissue-specific phenotypes is currently unknown. Here we ...
    • A TALEN Genome-Editing System for Generating Human Stem Cell-Based Disease Models 

      Ding, Qiurong; Lee, Youn-Kyoung; Schaefer, Esperance Anne Kreek; Peters, Derek Tilghman; Veres, Adrian; Kim, Kevin; Kuperwasser, Nicolas; Motola, Daniel L; Meissner, Torsten B; Hendriks, William; Trevisan, Marta; Gupta, Rajat; Moisan, Annie; Banks, Eric; Friesen, Max; Schinzel, Robert T.; Xia, Fang; Tang, Alexander; Xia, Yulei; Figueroa, Emmanuel; Wann, Amy; Ahfeldt, Tim; Daheron, Laurence Marie; Zhang, Feng; Rubin, Lee; Peng, Lee F; Chung, Raymond Taeyong; Musunuru, Kiran; Cowan, Chad A. (Elsevier BV, 2013)
      Transcription activator-like effector nucleases (TALENs) are a new class of engineered nucleases that are easier to design to cleave at desired sites in a genome than previous types of nucleases. We report here the use of ...