Browsing by Author "Gewurz, Benjamin"
Now showing items 1-3 of 3
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NF-κB and IRF7 Pathway Activation by Epstein-Barr Virus Latent Membrane Protein 1
Ersing, Ina; Bernhardt, Katharina; Gewurz, Benjamin E. (MDPI, 2013)The principal Epstein-Barr virus (EBV) oncoprotein, Latent Membrane Protein 1 (LMP1), is expressed in most EBV-associated human malignancies. LMP1 mimics CD40 receptor signaling to provide infected cells with constitutive ... -
Simian Virus 40 and Human Polyomavirus Oncogenic Perturbations
Berrios, Christian Jose (2016-07-25)Polyomaviruses have widespread prevalence across many animal species. Polyomaviruses are small DNA tumor viruses that endow their host cells with proliferative signals through interactions between their small T (ST) and ... -
TRAF1 Coordinates Polyubiquitin Signaling to Enhance Epstein-Barr Virus LMP1-Mediated Growth and Survival Pathway Activation
Greenfeld, Hannah; Takasaki, Kaoru; Walsh, Michael J.; Ersing, Ina; Bernhardt, Katharina; Ma, Yijie; Fu, Bishi; Ashbaugh, Camille W.; Cabo, Jackson; Mollo, Sarah B.; Zhou, Hufeng; Li, Shitao; Gewurz, Benjamin E. (Public Library of Science, 2015)The Epstein-Barr virus (EBV) encoded oncoprotein Latent Membrane Protein 1 (LMP1) signals through two C-terminal tail domains to drive cell growth, survival and transformation. The LMP1 membrane-proximal TES1/CTAR1 domain ...