Browsing by Author "Oukka, Mohamed"

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Adaptive Autoimmunity and Foxp3-Based Immunoregulation in Zebrafish

Quintana, Francisco Javier; Iglesias, Antonio H.; Farez, Mauricio F.; Caccamo, Mario; Burns, Evan J.; Kassam, Nasim; Oukka, Mohamed; Weiner, Howard Lee (Public Library of Science, 2010)

Background: Jawed vertebrates generate their immune-receptor repertoire by a recombinatorial mechanism that has the potential to produce harmful autoreactive lymphocytes. In mammals, peripheral tolerance to self-antigens ...
Exogenous IFN-γ Ex Vivo Shapes the Alloreactive T-Cell Repertoire by Inhibition of Th17 Responses and Generation of Functional Foxp3+ Regulatory T Cells

Feng, Gang; Gao, Wenda; Strom, Terry Barton; Oukka, Mohamed; Francis, Ross S; Wood, Kathryn J; Bushell, Andrew (WILEY-VCH Verlag, 2008)

Interferon (IFN)-γ was originally characterized as a pro-inflammatory cytokine with T helper type 1-inducing activity, but subsequent work has demonstrated that mice deficient in IFN-γ or IFN-γ receptor show exacerbated ...