Now showing items 1-2 of 2

    • Efficient Ablation of Genes in Human Hematopoietic Stem and Effector Cells using CRISPR/Cas9 

      Mandal, Pankaj Kumar; Ferreira, Leonardo Manuel Ramos; Collins, Ryan; Meissner, Torsten B; Boutwell, C; Friesen, Max; Vrbanac, Vladimir; Garrison, Brian Scott; Stortchevoi, Alexei; Bryder, David; Musunuru, Kiran; Brand, Harrison Andrew; Tager, Andrew Martin; Allen, Todd; Talkowski, Michael Edward; Rossi, Derrick J; Cowan, Chad A. (Elsevier BV, 2014)
      Genome editing via CRISPR/Cas9 has rapidly become the tool of choice by virtue of its efficacy and ease of use. However, CRISPR/Cas9-mediated genome editing in clinically relevant human somatic cells remains untested. Here, ...
    • Proliferation-Dependent Alterations of the DNA Methylation Landscape Underlie Hematopoietic Stem Cell Aging 

      Beerman, Isabel Eleanor; Bock, Christoph; Garrison, Brian Scott; Smith, Zachary D.; Gu, Hongcang; Meissner, Alexander; Rossi, Derrick J (Elsevier BV, 2013)
      The functional potential of hematopoietic stem cells (HSCs) declines during aging, and in doing so, significantly contributes to hematopoietic pathophysiology in the elderly. To explore the relationship between age-associated ...