Browsing by Author "Chung, Raymond"

Now showing items 1-20 of 29

    • The Absence of Obstructive Sleep Apnea May Protect against Non-Alcoholic Fatty Liver in Patients Undergoing Bariatric Surgery 

      Corey, Kathleen Elizabeth; Misdraji, Joseph; Zheng, Zheng; Malecki, Kyle M.; Kneeman, Jacob; Gelrud, Louis; Chung, Raymond Taeyong (Public Library of Science, 2013)
      Background: Non-alcoholic fatty liver disease (NAFLD) is the most common cause of liver disease worldwide and its progressive form, steatohepatitis, will be the leading indication for liver transplant by 2020. While risk ...

    • ARF1 and GBF1 Generate a PI4P-Enriched Environment Supportive of Hepatitis C Virus Replication 

      Zhang, Leiliang; Hong, Zhi; Lin, Wenyu; Shao, Run-Xuan; Goto, Kaku; Hsu, Victor Wee; Chung, Raymond Taeyong (Public Library of Science, 2012)
      Cellular levels of phosphatidylinositol 4-phosphate (PI4P) have been shown to be upregulated during RNA replication of several viruses, including the HCV replicon model. However, whether PI4P is required in an infectious ...

    • Broadly directed virus-specific CD4+ T cell responses are primed during acute hepatitis C infection, but rapidly disappear from human blood with viral persistence 

      Schulze zur Wiesch, Julian; Ciuffreda, Donatella; Lewis-Ximenez, Lia; Kasprowicz, Victoria Olivia; Nolan, Brian E.; Streeck, Hendrik; Aneja, Jasneet; Reyor, Laura L.; Allen, Todd; Lohse, Ansgar W.; McGovern, Barbara; Chung, Raymond Taeyong; Kwok, William W.; Kim, Arthur Yu-Shin; Lauer, Georg (The Rockefeller University Press, 2012)
      Vigorous proliferative CD4+ T cell responses are the hallmark of spontaneous clearance of acute hepatitis C virus (HCV) infection, whereas comparable responses are absent in chronically evolving infection. Here, we ...

    • CCAAT/Enhancer-Binding Protein Homologous (CHOP) Protein Promotes Carcinogenesis in the DEN-Induced Hepatocellular Carcinoma Model 

      Scaiewicz, Viviana; Nahmias, Avital; Chung, Raymond T.; Mueller, Tobias; Tirosh, Boaz; Shibolet, Oren (Public Library of Science, 2013)
      Background and Aims C/EBP homologous protein (CHOP) plays pro-apoptotic roles in the integrated stress response. Recently, a tumor suppressive role for CHOP was demonstrated in lung cancer via regulation of tumor metabolism. ...

    • Chronic hepatitis C infection–induced liver fibrogenesis is associated with M2 macrophage activation 

      Bility, Moses T.; Nio, Kouki; Li, Feng; McGivern, David R.; Lemon, Stanley M.; Feeney, Eoin R.; Chung, Raymond T.; Su, Lishan (Nature Publishing Group, 2016)
      The immuno-pathogenic mechanisms of chronic hepatitis C virus (HCV) infection remain to be elucidated and pose a major hurdle in treating or preventing chronic HCV-induced advanced liver diseases such as cirrhosis. Macrophages ...

    • Circulating Mitochondrial DNA in Patients in the ICU as a Marker of Mortality: Derivation and Validation 

      Nakahira, Kiichi; Kyung, Sun-Young; Rogers, Angela J.; Gazourian, Lee; Youn, Sojung; Massaro, Anthony F.; Quintana, Carolina; Osorio, Juan C.; Wang, Zhaoxi; Zhao, Yang; Lawler, Laurie A.; Christie, Jason D.; Meyer, Nuala J.; Causland, Finnian R. Mc.; Waikar, Sushrut S.; Waxman, Aaron B.; Chung, Raymond T.; Bueno, Raphael; Rosas, Ivan O.; Fredenburgh, Laura E.; Baron, Rebecca M.; Christiani, David C.; Hunninghake, Gary M.; Choi, Augustine M. K. (Public Library of Science, 2013)
      Background: Mitochondrial DNA (mtDNA) is a critical activator of inflammation and the innate immune system. However, mtDNA level has not been tested for its role as a biomarker in the intensive care unit (ICU). We hypothesized ...

    • Circulating Soluble CD163 is Associated with Steatohepatitis and Advanced Fibrosis in Nonalcoholic Fatty Liver Disease 

      Mueller, Jessica L; Feeney, Eoin R; Zheng, Hui; Misdraji, Joseph; Kruger, Annie J; Alatrakchi, Nadia; King, Lindsay Y; Gelrud, Louis; Corey, Kathleen E; Chung, Raymond T (Nature Publishing Group, 2015)
      OBJECTIVES: Soluble CD163 (sCD163), a marker of Kupffer cell activation detectable in serum, correlates with inflammation and fibrosis in chronic viral hepatitis, but its role in nonalcoholic fatty liver disease is unknown. ...

    • The Effect of Hepatitis C Virologic Clearance on Cardiovascular Disease Biomarkers in Human Immunodeficiency Virus/Hepatitis C Virus Coinfection 

      Chew, Kara W.; Hua, Lei; Bhattacharya, Debika; Butt, Adeel A.; Bornfleth, Lorelei; Chung, Raymond T.; Andersen, Janet W.; Currier, Judith S. (Oxford University Press, 2014)
      Background: Successful hepatitis C virus (HCV) treatment may reduce cardiovascular disease (CVD) risk and improve levels of CVD biomarkers produced outside the liver (nonhepatic biomarkers). Methods: Stored serum or plasma ...

    • Efficacy and Safety of Direct Acting Antivirals in Kidney Transplant Recipients with Chronic Hepatitis C Virus Infection 

      Lin, Ming V.; Sise, Meghan E.; Pavlakis, Martha; Amundsen, Beth M.; Chute, Donald; Rutherford, Anna E.; Chung, Raymond T.; Curry, Michael P.; Hanifi, Jasmine M.; Gabardi, Steve; Chandraker, Anil; Heher, Eliot C.; Elias, Nahel; Riella, Leonardo V. (Public Library of Science, 2016)
      The prevalence of Hepatitis C Virus (HCV) infection is significantly higher in patients with end-stage renal disease compared to the general population and poses important clinical challenges in patients who undergo kidney ...

    • Epidermal Growth Factor Gene Functional Polymorphism and the Risk of Hepatocellular Carcinoma in Patients With Cirrhosis 

      Tanabe, Kenneth Kenji; Lemoine, Antoinette; Finkelstein, Dianne Madelyn; Kawasaki, Hiroshi; Fujii, Tsutomu; Chung, Raymond Taeyong; Lauwers, Gregory Y.; Kulu, Yakup; Muzikansky, Alona; Kuruppu, Darshini; Lanuti, Michael; Goodwin, Jonathan M.; Azoulay, Daniel; Fuchs, Bryan C. (American Medical Association (AMA), 2008)
      Context: Overexpression of epidermal growth factor (EGF) in the liver induces transformation to hepatocellular carcinoma in animal models. Polymorphisms in the EGF gene modulate EGF levels. Objective: To assess the ...

    • Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis 

      Wagschal, Alexandre; Najafi-Shoushtari, S Hani; Wang, Lifeng; Goedeke, Leigh; Sinha, Sumita; deLemos, Andrew S; Black, Josh C; Ramírez, Cristina M; Li, Yingxia; Tewhey, Ryan; Hatoum, Ida; Shah, Naisha; Lu, Yong; Kristo, Fjoralba; Psychogios, Nikolaos; Vrbanac, Vladimir; Lu, Yi-Chien; Hla, Timothy T; de Cabo, Rafael; Tsang, John S; Schadt, Eric; Sabeti, Pardis Christine; Kathiresan, Sekar; Cohen, David E; Whetstine, Johnathan; Chung, Raymond Taeyong; Fernández-Hernando, Carlos; Kaplan, Lee Michael; Bernards, Andre; Gerszten, Robert Edgardo; Naar, Anders Michael (Springer Nature, 2015)
      Genome-wide association studies (GWASs) have linked genes to various pathological traits. However, the potential contribution of regulatory noncoding RNAs, such as microRNAs (miRNAs), to a genetic predisposition to ...

    • HCV induces transforming growth factor β1 through activation of endoplasmic reticulum stress and the unfolded protein response 

      Chusri, Pattranuch; Kumthip, Kattareeya; Hong, Jian; Zhu, Chuanlong; Duan, Xiaoqiong; Jilg, Nikolaus; Fusco, Dahlene N.; Brisac, Cynthia; Schaefer, Esperance A.; Cai, Dachuan; Peng, Lee F.; Maneekarn, Niwat; Lin, Wenyu; Chung, Raymond T. (Nature Publishing Group, 2016)
      HCV replication disrupts normal endoplasmic reticulum (ER) function and activates a signaling network called the unfolded protein response (UPR). UPR is directed by three ER transmembrane proteins including ATF6, IRE1, and ...

    • Hepatic Injury in Nonalcoholic Steatohepatitis Contributes to Altered Intestinal Permeability 

      Luther, Jay; Garber, John J.; Khalili, Hamed; Dave, Maneesh; Bale, Shyam Sundhar; Jindal, Rohit; Motola, Daniel L.; Luther, Sanjana; Bohr, Stefan; Jeoung, Soung Won; Deshpande, Vikram; Singh, Gurminder; Turner, Jerrold R.; Yarmush, Martin L.; Chung, Raymond T.; Patel, Suraj J. (2015)
      BACKGROUND & AIMS Emerging data suggest that changes in intestinal permeability and increased gut microbial translocation contribute to the inflammatory pathway involved in nonalcoholic steatohepatitis (NASH) development. ...

    • Hepatitis C Virus and Hepatocarcinogenesis 

      Jeong, Soung Won; Jang, Jae Young; Chung, Raymond Taeyong (The Korean Association for the Study of the Liver, 2012)
      Hepatitis C virus (HCV) is an RNA virus that is unable to integrate into the host genome. However, its proteins interact with various host proteins and induce host responses. The oncogenic process of HCV infection is slow ...

    • Host Genetics Predict Clinical Deterioration in HCV-Related Cirrhosis 

      King, Lindsay Y.; Johnson, Kara B.; Zheng, Hui; Wei, Lan; Gudewicz, Thomas; Hoshida, Yujin; Corey, Kathleen E.; Ajayi, Tokunbo; Ufere, Nneka; Baumert, Thomas F.; Chan, Andrew T.; Tanabe, Kenneth K.; Fuchs, Bryan C.; Chung, Raymond T. (Public Library of Science, 2014)
      Single nucleotide polymorphisms (SNPs) in the epidermal growth factor (EGF, rs4444903), patatin-like phospholipase domain-containing protein 3 (PNPLA3, rs738409) genes, and near the interleukin-28B (IL28B, rs12979860) gene ...

    • IgG4-associated cholangitis: a comparative histological and immunophenotypic study with primary sclerosing cholangitis on liver biopsy material 

      Deshpande, Vikram; Sainani, Nisha I.; Chung, Raymond Taeyong; Pratt, Daniel S.; Mentha, Gilles; Rubbia-Brandt, Laura; Lauwers, Gregory Y. (Springer Nature, 2009)
      IgG4-associated cholangitis is a steroid-responsive hepatobiliary inflammatory condition associated with autoimmune pancreatitis that clinically and radiologically mimics primary sclerosing cholangitis. In this study, we ...

    • Impaired hepatitis C virus-specific T cell responses and recurrent hepatitis C virus in HIV coinfection 

      Kim, Arthur Yu-Shin; Schulze zur Wiesch, Julian; Kuntzen, Thomas; Timm, Joerg; Kaufmann, Daniel; Duncan, Jared E.; Jones, Andrea M.; Wurcel, Alysse G.; Davis, Benjamin Thomas; Gandhi, Rajesh Tim; Robbins, Gregory Kimball; Allen, Todd; Chung, Raymond Taeyong; Lauer, Georg; Walker, Bruce David (Public Library of Science, 2006)
      Background: Hepatitis C virus (HCV)-specific T cell responses are critical for spontaneous resolution of HCV viremia. Here we examined the effect of a lymphotropic virus, HIV-1, on the ability of coinfected patients to ...

    • Inhibition of HCV by the serpin antithrombin III 

      Asmal, Mohammed; Seaman, Michael S.; Lin, Wenyu; Chung, Raymond Taeyong; Letvin, Norman L; Geiben-Lynn, Ralf (BioMed Central, 2012)
      Background: Although there have been dramatic strides made recently in the treatment of chronic hepatitis C virus infection, interferon-α based therapy remains challenging for certain populations, including those with ...

    • Long noncoding RNAs expressed in human hepatic stellate cells form networks with extracellular matrix proteins 

      Zhou, Chan; York, Samuel R.; Chen, Jennifer Y.; Pondick, Joshua V.; Motola, Daniel L.; Chung, Raymond T.; Mullen, Alan C. (BioMed Central, 2016)
      Background: Hepatic fibrosis is the underlying cause of cirrhosis and liver failure in nearly every form of chronic liver disease, and hepatic stellate cells (HSCs) are the primary cell type responsible for fibrosis. Long ...

    • New Treatments for Chronic Hepatitis C 

      Jang, Jae Young; Chung, Raymond Taeyong (The Korean Association for the Study of the Liver, 2010)
      Treatments for chronic hepatitis C has evolved significantly in the past 15 years. The standard of care (SOC) is peginterferon alfa-2a/-2b with ribavirin for 48 weeks or 24 weeks in patients infected with HCV genotype 1 ...