Now showing items 1-3 of 3

    • Coordinated Evolution of Influenza A Surface Proteins 

      Neverov, Alexey D.; Kryazhimskiy, Sergey; Plotkin, Joshua B.; Bazykin, Georgii A. (Public Library of Science, 2015)
      The surface proteins hemagglutinin (HA) and neuraminidase (NA) of human influenza A virus evolve under selection pressures to escape adaptive immune responses and antiviral drug treatments. In addition to these external ...
    • Inexpensive Multiplexed Library Preparation for Megabase-Sized Genomes 

      Baym, Michael; Kryazhimskiy, Sergey; Lieberman, Tami D.; Chung, Hattie; Desai, Michael M.; Kishony, Roy (Public Library of Science, 2015)
      Whole-genome sequencing has become an indispensible tool of modern biology. However, the cost of sample preparation relative to the cost of sequencing remains high, especially for small genomes where the former is dominant. ...
    • Loss and Recovery of Genetic Diversity in Adapting Populations of HIV 

      Pennings, Pleuni S.; Kryazhimskiy, Sergey; Wakeley, John (Public Library of Science, 2014)
      The evolution of drug resistance in HIV occurs by the fixation of specific, well-known, drug-resistance mutations, but the underlying population genetic processes are not well understood. By analyzing within-patient ...