Now showing items 1-5 of 5

    • A direct GABAergic output from the basal ganglia to frontal cortex 

      Saunders, Arpiar; Oldenburg, Ian A.; Berezovskii, Vladimir K.; Johnson, Caroline A.; Kingery, Nathan D.; Elliott, Hunter L.; Xie, Tiao; Gerfen, Charles R.; Sabatini, Bernardo L. (2014)
      The basal ganglia (BG) are phylogenetically conserved subcortical nuclei necessary for coordinated motor action and reward learning1. Current models postulate that the BG modulate cerebral cortex indirectly via an inhibitory ...
    • High Content Image Analysis Identifies Novel Regulators of Synaptogenesis in a High-Throughput RNAi Screen of Primary Neurons 

      Nieland, Thomas J. F.; Logan, David J.; Saulnier, Jessica; Lam, Daniel; Johnson, Caroline; Root, David E.; Carpenter, Anne E.; Sabatini, Bernardo L. (Public Library of Science, 2014)
      The formation of synapses, the specialized points of chemical communication between neurons, is a highly regulated developmental process fundamental to establishing normal brain circuitry. Perturbations of synapse formation ...
    • Novel recombinant adeno-associated viruses for Cre activated and inactivated transgene expression in neurons 

      Saunders, Arpiar Bruce; Johnson, Caroline; Sabatini, Bernardo Luis (Frontiers Media S.A., 2012)
      Understanding the organization of the nervous system requires methods for dissecting the contributions of each component cell type to circuit function. One widely used approach combines genetic targeting of Cre recombinase ...
    • Recurrent network activity drives striatal synaptogenesis 

      Kozorovitskiy, Yevgenia; Saunders, Arpiar; Johnson, Caroline A.; Lowell, Bradford B.; Sabatini, Bernardo L. (2012)
      Neural activity during development critically shapes postnatal wiring of the mammalian brain. This is best illustrated by the sensory systems, in which the patterned feed-forward excitation provided by sensory organs and ...
    • Temporal dynamics of a homeostatic pathway controlling neural network activity 

      Bateup, Helen S.; Denefrio, Cassandra L.; Johnson, Caroline A.; Saulnier, Jessica L.; Sabatini, Bernardo L. (Frontiers Media S.A., 2013)
      Neurons use a variety of mechanisms to homeostatically regulate neural network activity in order to maintain firing in a bounded range. One such process involves the bi-directional modulation of excitatory synaptic drive ...