Browsing by Author "Fava, Maurizio"
Now showing items 1-20 of 24
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Celebrity Suicides and Their Differential Influence on Suicides in the General Population: A National Population-Based Study in Korea
Myung, Woojae; Won, Hong-Hee; Fava, Maurizio; Mischoulon, David; Yeung, Albert; Lee, Dongsoo; Kim, Doh Kwan; Jeon, Hong Jin (Korean Neuropsychiatric Association, 2015)Objective: Although evidence suggests that there is an increase in suicide rates in the general population following celebrity suicide, the rates are heterogeneous across celebrities and countries. It is unclear which is ... -
Comparisons of Subthreshold Versus Full Posttraumatic Stress Disorder Distinguished by Subjective Functional Impairment Among Train Drivers: A Population-Based Nationwide Study in South Korea
Baek, Ji Hyun; Kim, Ji-Hae; Kim, Bin-Na; Park, Seung Jin; Fava, Maurizio; Mischoulon, David; Lee, Dongsoo; Jeon, Hong Jin (Korean Neuropsychiatric Association, 2017)Objective: Subthreshold posttraumatic stress disorder (SPTSD), a condition that meets the full symptomatic criteria of posttraumatic stress disorder (PTSD) without subjective functional impairment, has yet to be fully ... -
Effect of Adjunctive Pimavanserin on Sleep/Wakefulness in Patients With Major Depressive Disorder
Jha, Manish; Fava, Maurizio; Freeman, Marlene; Thase, Michael; Papakostas, George; Shelton, Richard; Trivedi, Madhukar; Birks, Bryan; Liu, Keith; Stankovic, Srdjan (Physicians Postgraduate Press, Inc, 2020-12-01)ABSTRACT Objective: This was an analysis of pimavanserin, a 5-hydroxytryptamine 2A antagonist/inverse receptor agonist, on dysregulated sleep in patients with major depressive disorder (MDD) by DSM-5 criteria and an ... -
Effectiveness of the Relaxation Response-Based Group Intervention for Treating Depressed Chinese American Immigrants: A Pilot Study
Yeung, Albert; Slipp, Lauren E.; Niles, Halsey; Jacquart, Jolene; Chow, Choi-Ling; Fava, Maurizio; Denninger, John W.; Benson, Herbert; Fricchione, Gregory L. (MDPI, 2014)Background:: This study examined the feasibility, safety and efficacy of an 8-week Relaxation Response (RR)-based group. Methods:: Twenty-two depressed Chinese American immigrants were recruited. Outcomes measures were ... -
Effects of levomilnacipran ER on fatigue symptoms associated with major depressive disorder
Freeman, Marlene P.; Fava, Maurizio; Gommoll, Carl; Chen, Changzheng; Greenberg, William M.; Ruth, Adam (Lippincott Williams And Wilkins, 2016)The aim of this study was to evaluate the effects of levomilnacipran extended-release (ER) on depression-related fatigue in adults with major depressive disorder. Post-hoc analyses of five phase III trials were carried ... -
Effects of Open-Label, Adjunctive Ganaxolone on Persistent Depression Despite Adequate Antidepressant Treatment in Postmenopausal Women
Dichtel, Laura; Nyer, Maren; Dording, Christina; Fisher, Lauren; Cusin, Cristina; Shapero, Benjamin; Pedrelli, Paola; Kimball, Allison; Rao, Elizabeth; Mischoulon, David; Fava, Maurizio; Miller, Karen K. (Physicians Postgraduate Press, Inc, 2020-06-09)Abstract Objective: The neuroactive steroid metabolite of progesterone, allopregnanolone, is a positive allosteric modulator of GABAA receptors and a putative treatment for mood disorders. We performed a pilot study to ... -
Efficacy and Safety of AXS-05 (Dextromethorphan-Bupropion) in Patients With Major Depressive Disorder
Iosifescu, Dan V.; Jones, Amanda; O’Gorman, Cedric; Streicher, Caroline; Feliz, Samantha; Fava, Maurizio; Tabuteau, Herriot (Physicians Postgraduate Press, Inc, 2022-05-30)Abstract Objective: Altered glutamatergic neurotransmission has been implicated in the pathogenesis of depression. This trial evaluated the efficacy and safety of AXS-05 (dextromethorphan-bupropion), an oral NMDA receptor ... -
Efficacy of Esketamine Augmentation in Major Depressive Disorder: A Meta-Analysis
Papakostas, George; Chaaya Salloum, Naji; Hock, Rebecca; Jha, Manish K.; Murrough, James W.; Mathew, Sanjay J.; Iosifescu, Daniel V.; Fava, Maurizio (Physicians Postgraduate Press, Inc, 2020-05-26)Objective: Esketamine, the s-enantiomer of ketamine, was recently approved as a rapid-acting intranasal therapy for depression and is currently under development for suicidality. The authors sought to determine the efficacy ... -
Epidemiologic Evidence Concerning the Bereavement Exclusion in Major Depression
Gilman, Stephen Edward; Breslau, Joshua; Trinh, Nhi-Ha Thuy; Fava, Maurizio; Murphy, Jane M.; Smoller, Jordan W (American Medical Association (AMA), 2012) -
Factors that distinguish college students with depressive symptoms with and without suicidal thoughts
Nyer, Maren Bess; Holt, Daphne Jane; Pedrelli, Paola; Fava, Maurizio; Ameral, Victoria; Cassiello, Clair F.; Nock, Matthew K.; Ross, Margaret; Hutchinson, Dori; Farabaugh, Amy (Springer, 2013)BACKGROUND Suicide among college students is a significant public health concern. Although suicidality is linked to depression, not all depressed college students experience suicidal ideation (SI). The primary aim of ... -
Gender Differences in Somatic Symptoms and Current Suicidal Risk in Outpatients with Major Depressive Disorder
Jeon, Hong Jin; Woo, Jong-Min; Kim, Hyo-Jin; Fava, Maurizio; Mischoulon, David; Cho, Seong Jin; Chang, Sung Man; Park, Doo-Heum; Kim, Jong Woo; Yoo, Ikki; Heo, Jung-Yoon; Hong, Jin Pyo (Korean Neuropsychiatric Association, 2016)Objective: Although somatic symptoms are common complaints of patients with major depressive disorder (MDD), their associations with suicide are still unclear. Methods: A total of 811 MDD outpatients of aged between 18 to ... -
Omega-3 Fatty Acids for Major Depressive Disorder With High Inflammation
Mischoulon, David; Dunlop, Boadie W.; Kinkead, Becky; Schettler, Pamela J.; Lamon-Fava, Stefania; Rakofsky, Jeffrey J.; Nierenberg, Andrew; Clain, Alisabet J.; Crowe, Tanja Mletzko; Wong, Andrea; Felger, Jennifer C.; Sangermano, Lisa; Ziegler, Thomas R.; Cusin, Cristina; Fisher, Lauren B.; Fava, Maurizio; Rapaport, Mark Hyman (Physicians Postgraduate Press, Inc, 2022-08-22)Objective: We compared the impact of three eicosapentaenoic acid (EPA) doses versus placebo on inflammatory biomarkers and depressive symptoms. Methods: We randomized 61 unmedicated adults (75% female; 45.5 ± 13.8 years) ... -
Paraquat Prohibition and Change in the Suicide Rate and Methods in South Korea
Myung, Woojae; Lee, Geung-Hee; Won, Hong-Hee; Fava, Maurizio; Mischoulon, David; Nyer, Maren; Kim, Doh Kwan; Heo, Jung-Yoon; Jeon, Hong Jin (Public Library of Science, 2015)The annual suicide rate in South Korea is the highest among the developed countries. Paraquat is a highly lethal herbicide, commonly used in South Korea as a means for suicide. We have studied the effect of the 2011 paraquat ... -
A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study of Adjunctive Pimavanserin in Patients With Major Depressive Disorder and an Inadequate Response to Therapy (CLARITY)
Fava, Maurizio; Dirks, Bryan; Shelton, Richard C.; Thase, Michael E.; Trivedi, Madhukar H.; Liu, Keith; Stankovic, Srdjan; Freeman, Marlene; Papakostas, George (Physicians Postgraduate Press, Inc, 2019-09-24)Objective: Pimavanserin is a 5-hydroxytryptamine2A antagonist/inverse receptor agonist. In this Phase 2 study, we studied the efficacy and safety of pimavanserin as adjunctive therapy in patients with major depressive ... -
Reduced Caudate and Nucleus Accumbens Response to Rewards in Unmedicated Subjects with Major Depressive Disorder
Pizzagalli, Diego; Holmes, Avram J.; Dillon, Daniel G.; Goetz, Elena L.; Birk, Jeffrey L.; Bogdan, Ryan; Dougherty, Darin D.; Iosifescu, Dan V.; Rauch, Scott L.; Fava, Maurizio (American Psychiatric Association, 2009)Objective: Major depressive disorder is characterized by impaired reward processing, possibly due to dysfunction in the basal ganglia. However, few neuroimaging studies of depression have distinguished between anticipatory ... -
Reduced Hedonic Capacity in Major Depressive Disorder: Evidence from a Probabilistic Reward Task
Pizzagalli, Diego; Iosifescu, Dan; Hallett, Lindsay A.; Ratner, Kyle G.; Fava, Maurizio (Elsevier, 2008)Objective: Anhedonia, the lack of reactivity to pleasurable stimuli, is a cardinal feature of depression that has received renewed interest as a potential endophenotype of this debilitating disease. The goal of the ... -
Reduced Venous Blood Basophil Count and Anxious Depression in Patients with Major Depressive Disorder
Baek, Ji Hyun; Kim, Hee-Jin; Fava, Maurizio; Mischoulon, David; Papakostas, George I; Nierenberg, Andrew; Heo, Jung-Yoon; Jeon, Hong Jin (Korean Neuropsychiatric Association, 2016)Objective: Anxious depression has a distinct neurobiology, clinical course and treatment response from non-anxious depression. Role of inflammation in anxious depression has not been examined. As an exploratory study to ... -
REL-1017 (Esmethadone) as Adjunctive Treatment in Patients With Major Depressive Disorder: A Phase 2a Randomized Double-Blind Trial
Fava, Maurizio; Stahl, Stephen; Pani, Luca; De Martin, Sara; Pappagallo, Marco; Guidetti, Clotilde; Alimonti, Andrea; Bettini, Ezio; Mangano, Richard M.; Wessel, Thomas; de Somer, Marc; Caron, Judy; Vitolo, Ottavio V.; DiGuglielmo, Gina R.; Gilbert, Adam; Mehta, Hiren; Kearney, Morgan; Mattarei, Andrea; Gentilucci, Marco; Folli, Franco; Traversa, Sergio; Inturrisi, Charles E.; Manfredi, Paolo L. (American Psychiatric Association Publishing, 2022-02)ABSTRACT Objective: The relationship between the duration of major depressive disorder (MDD) and therapeutic response to standard antidepressant treatment (SAT) is unknown. N-methyl-D- aspartate receptor (NMDAR) ... -
Residual Sleep Disturbance and Risk of Relapse During the Continuation/Maintenance Phase Treatment of Major Depressive Disorder with the Selective Serotonin Reuptake Inhibitor Fluoxetine
Yang, Huaiyu; Sinicropi-Yao, Lara; Chuzi, Sarah; Youn, Soo Jeong; Clain, Alisabet; Baer, Lee; Chen, Ying; McGrath, Patrick J; Fava, Maurizio; Papakostas, George I (BioMed Central, 2010)Background: Relapse of major depressive disorder (MDD) is a common clinical problem. This study was designed to determine whether residual sleep disturbance (insomnia and hypersomnia) predict risk of relapse during the ... -
Review of Suicide Prevention Programs: Massachusetts, United States, in Comparison with Seoul
Baek, Ji Hyun; Park, Jong-Ik; Ahn, Jeonghoon; Roh, Sung-won; Heo, Jung-Yoon; Fava, Maurizio; Mischoulon, David; Jeon, Hong Jin (Korean Neuropsychiatric Association, 2015)Suicide is a tragedy that has massive impact on society. In order to prevent suicide, active government intervention is necessary. The suicide rate in Seoul is rapidly increasing and is more than five times higher than ...