Browsing by Author "Hoffmeister, Karin"

Now showing items 1-3 of 3

    • Cytoskeletal Mechanics of Proplatelet Maturation and Platelet Release 

      Thon, Jonathan Noah; Montalvo, Alejandro; Patel-Hett, Sunita; Devine, Matthew T.; Richardson, Jennifer L.; Ehrlicher, Allen Joseph; Larson, Mark K.; Hoffmeister, Karin Maria; Hartwig, John Henry; Italiano, Joseph E. (Rockefeller University Press, 2010)
      Megakaryocytes generate platelets by remodeling their cytoplasm into long proplatelet extensions, which serve as assembly lines for platelet production. Although the mechanics of proplatelet elongation have been studied, ...

    • Desialylation is a mechanism of Fc-independent platelet clearance and a therapeutic target in immune thrombocytopenia 

      Li, June; van der Wal, Dianne E.; Zhu, Guangheng; Xu, Miao; Yougbare, Issaka; Ma, Li; Vadasz, Brian; Carrim, Naadiya; Grozovsky, Renata; Ruan, Min; Zhu, Lingyan; Zeng, Qingshu; Tao, Lili; Zhai, Zhi-min; Peng, Jun; Hou, Ming; Leytin, Valery; Freedman, John; Hoffmeister, Karin M.; Ni, Heyu (Nature Pub. Group, 2015)
      Immune thrombocytopenia (ITP) is a common bleeding disorder caused primarily by autoantibodies against platelet GPIIbIIIa and/or the GPIb complex. Current theory suggests that antibody-mediated platelet destruction occurs ...

    • Dual roles for hepatic lectin receptors in the clearance of chilled platelets 

      Rumjantseva, Viktoria; Grewal, Prabhjit K.; Wandall, Hans H.; Josefsson, Emma C.; Sørensen, Anne Louise; Larson, Göran; Marth, Jamey D.; Hartwig, John H.; Hoffmeister, Karin M. (2015)
      Chilling rapidly (<4 h) clusters Glycoprotein - (GP)Ib receptors on blood platelets, and ß2-integrins of hepatic macrophages bind ßGlcNAc residues in the clusters leading to rapid clearance of acutely chilled platelets ...