Now showing items 1-5 of 5

    • Pancreas-Targeted NIR Fluorophores for Dual-Channel Image-Guided Abdominal Surgery 

      Wada, Hideyuki; Hyun, Hoon; Vargas, Christina; Gravier, Julien; Park, GwangLi; Gioux, Sylvain; Frangioni, John V.; Henary, Maged; Choi, Hak Soo (Ivyspring International Publisher, 2015)
      Objective: Pancreas-related complications are some of the most serious ones in abdominal surgery. The goal of this study was to develop and validate novel near-infrared (NIR) fluorophores that would enable real-time pancreas ...
    • Prototype Nerve-Specific Near-Infrared Fluorophores 

      Park, Min Ho; Hyun, Hoon; Ashitate, Yoshitomo; Wada, Hideyuki; Park, GwangLi; Lee, Jeong Heon; Njiojob, Costyl; Henary, Maged; Frangioni, John V.; Choi, Hak Soo (Ivyspring International Publisher, 2014)
      Nerve preservation is an important issue during most surgery because accidental transection or injury results in significant morbidity, including numbness, pain, weakness, or paralysis. Currently, nerves are still identified ...
    • Real-Time Monitoring of Tumorigenesis, Dissemination, & Drug Response in a Preclinical Model of Lymphangioleiomyomatosis/Tuberous Sclerosis Complex 

      Liu, Fangbing; Lunsford, Elaine P.; Tong, Jingli; Ashitate, Yoshitomo; Gibbs, Summer L.; Yu, Jane J; Choi, Hak Soo; Henske, Elizabeth Petri; Frangioni, John Vincent (Public Library of Science, 2012)
      Background: TSC2-deficient cells can proliferate in the lungs, kidneys, and other organs causing devastating progressive multisystem disorders such as lymphangioleiomyomatosis (LAM) and tuberous sclerosis complex (TSC). ...
    • Screening of Small Molecule Microarrays for Ligands Targeted to the Extracellular Epitopes of Living Cells 

      Lee, Jeong Heon; Bao, Kai; Frangioni, John V.; Choi, Hak Soo (2015)
      The screening of living cells using high-throughput microarrays is technically challenging. Great care must be taken in the chemical presentation of potential ligands and the number of collisions that cells make with them. ...
    • Structure-Inherent Targeting of NIR Fluorophores for Parathyroid and Thyroid Gland Imaging 

      Hyun, Hoon; Park, Min Ho; Owens, Eric A.; Wada, Hideyuki; Henary, Maged; Handgraaf, Hein J.M.; Vahrmeijer, Alexander L.; Frangioni, John V.; Choi, Hak Soo (2014)
      The typical method for creating targeted contrast agents requires covalent conjugation of separate targeting and fluorophore domains. In this study, we demonstrate that it is possible create tissue-specific near-infrared ...